Does Asprin Affect Fact Loss?
-
I'll try to keep my query as simple as possible. Please correct wherever my understanding is off.
I was thinking about a hypothetical protocol for people that were told they have insulin resistance. Since aspirin has been touted as helpful in this regard, its use would be considered in the protocol.
I've read that aspirin has been recommended for such individuals because it promotes glucose oxidation over fat oxidation, which makes sense to me. However, these individuals generally have a good store of body fat which is leaking FFA into the bloodstream and causing metabolic issues, such as the aforementioned insulin resistance.
Would the aspirin, then, affect their fat burning in a way that fat-loss (and PUFA depletion) is slowed or inhibited? I imagine the net effect is still positive, but I'm curious if their weight loss/PUFA depletion takes much longer, thus their total healing takes longer as well.
-
You are familiar with the Randall Cycle?
Anyway
These links / articles will answer your questionshttps://www.functionalps.com/blog/2012/04/22/ray-peat-phd-on-aspirin/
-
@sphagnum I think people overcomplicate this way too much. If you're fat, there is literally nothing that will even get close to the benefits you will get from becoming lean. Aspirin can help you get there by reducing inflammation along the way, but what really matters is that you get lean if you're fat.
Caffeine + aspirin can work synergistically to oppose inflammation and help the liver clear the fat influx caused by being in a deficit.
-
@Peatful I am familiar with the Randall Cycle and was going to mention it in the OP but didn't want to pigeon hole replies in case there were answers outside of that.
I know the Randall Cycle never fully shuts down the fat or carb burning in either direction, but I also don't know how far aspirin swings things in favor of carb burning.
Does aspirin simply 'normalize' a metabolically compromised person's RC back to carb burning, or does it push it to a point where fat burning is minimized and fat retention is still an issue?
-
@jamezb46
I agree that lean is the way to go, but achieving fat loss requires that fat be metabolized for energy when in said deficit. I don't know if aspirin may cause a great slowing of this by keeping the switch turned to carb burning.I'm also not sure how much of a deficit is safe without causing issues with thyroid and stress hormones, but that's a whole story I suppose.
-
Just realized the title says Fact Loss.
Wtf… -
@sphagnum said in Does Asprin Affect Fact Loss?:
I don't know if aspirin may cause a great slowing of this by keeping the switch turned to carb burning.
I won't take this "possibility" into account.
Impact of HD aspirin on platelet aggregation curve
https://mirzoune-ciboulette.forumactif.org/t2143-english-corner-impact-of-hd-aspirin-on-platelet-aggregation-curve#30423
My definition of “uncoupling energy metabolism”:
Uncoupling energy metabolism involves separating the ATP production process from the mitochondrial respiratory chain. This mechanism allows energy to be dissipated as heat (thermogenesis), thereby regulating cellular metabolism, free radical production, and potentially protecting against oxidative damage.
ATP = molecular energy source.Useful inof:
*) Aspirin's Role in Mitochondrial Oxygen Consumption and Fever
"Probably because of aspirin’s anti-fever effect, the medical culture tends to think of it as anti-thermogenic, despite its known stimulation of mitochondrial oxygen consumption. Like thyroid hormone, aspirin prevents stress-induced loss of sodium, which is an important part of our temperature and energy regulating system."
November 2020 - Ray Peat's Newsletter.
*) Aspirin and Inflammation: The Lesser-Known Pro-Oxidant Effect
"The fact that the inflammation-promoting enzymes, aromatase, cyclooxygenase, and nitric oxide synthase, which are inhibited by an oxidizing environment are also inhibited by aspirin, would strongly suggest that aspirin and salicylic acid are functioning as pro-oxidants."
July 2016 - Ray Peat's Newsletter.
*) Aspirin's Increased Vitamin K Requirement
"Aspirin makes you need more vitamin K, even when you aren’t using much. People who use aspirin for arthritis or cancer often take several grams a day."
Email Response by Ray Peat.
*) Impact of HD aspirin on platelet aggregation curve
https://mirzoune-ciboulette.forumactif.org/t2143-english-corner-impact-of-hd-aspirin-on-platelet-aggregation-curve#30423
NB: Life of platelet is affected until new ones are made if energy and material is available to make new ones. 10-12 days delay. Even with low amount (81 mg ASA).
Excerpt:
Summary
• Aspirin irreversibly inhibits platelet aggregation for the platelet’s lifespan (~10 days).
• Higher doses don’t add to inhibition but can alter COX-2 and redox signaling.
• Chronic, uninterrupted use leads to adaptive resistance.
• In a preventive or metabolic context, a reasonable rhythmic pattern might be:
5–10 days on => 10–14 days off, to reset platelets and avoid adaptation.
• Antioxidant sufficiency (vit E, C) and nutrient cofactors (D3, K2, Ca, B3) are key to maintaining balance. -
To lose fat you need to reduce mTOR activation, e.g. the body's growth signal. Else it will always reserve some of the calories you eat to build even more fat reserves and it becomes a endless cycle of e.g. not losing weight.
Reducing mTOR is primarily achieved through AMPK.
The three main ways to increase AMPK are:
- Intermittent Fasting
- Exercise (particularly HIIT, you need to be out of breath afterwards, weightlifting doesn't increase AMPK unless you go very high volume, neither does walking or light exercise)
- Exogenous AMPK like Berberine
