Prolactin is an innocent bystander and may even be beneficial
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Decreases bodyweight, yes it decreases metabolic rate
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Actually lets go on and say it PRESERVES metabolic rate despite extreme weight loss
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Some of the studies mention increased fatty acid oxidation. Could we say instead that prolactin, despite having benefits, is overall a stress hormone like cortisol? Cortisol also suppresses appetite but we rarely thing of it as a good think from a Peat perspective. So, prolactin would then still be a "bad" hormone worth suppressing.
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hmmm… interdasting….
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@engineer thyroid, testosterone, dopamine etc increase fatty acid oxidation, FAO does not mean a substance is stressfull. I suspect prolactin activation increases metabolism by increasing dopamine.
The cortisol comparison is extremely unfair; prolactin greatly reduces blood sugar, more so than bromocriptine itself whereas cortisol increases it.
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There is a study showing prolactin knockout caused decreases in glycolysis, pyruvare dehydrogenase and some steps of the kerbs cycle, but also greatly decreased fatty acid synthase genes. Beta oxidation genres remained neutral and slightly increased. I think nuking prolactin on a keto dietiet such as ex150, could be beneficial for that reason.
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@alfredoolivas mayhaps cortisol gets a universally bad rap as well
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@sunsunsun mayhaps you expand on that?
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@sunsunsun yeah it probably increases metabolic efficiency, but that makes one fat & it directly breaks down muscle tissue via the elvation of le amino transferases
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This study breaks it down nicely
https://academic.oup.com/endo/article/158/1/56/2751112?login=false -
Prolactin mogs in glucose tolerance tests and this is observed IRL too
