Prolactin is an innocent bystander and may even be beneficial
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@engineer thyroid, testosterone, dopamine etc increase fatty acid oxidation, FAO does not mean a substance is stressfull. I suspect prolactin activation increases metabolism by increasing dopamine.
The cortisol comparison is extremely unfair; prolactin greatly reduces blood sugar, more so than bromocriptine itself whereas cortisol increases it.
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There is a study showing prolactin knockout caused decreases in glycolysis, pyruvare dehydrogenase and some steps of the kerbs cycle, but also greatly decreased fatty acid synthase genes. Beta oxidation genres remained neutral and slightly increased. I think nuking prolactin on a keto dietiet such as ex150, could be beneficial for that reason.
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@alfredoolivas mayhaps cortisol gets a universally bad rap as well
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@sunsunsun mayhaps you expand on that?
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@sunsunsun yeah it probably increases metabolic efficiency, but that makes one fat & it directly breaks down muscle tissue via the elvation of le amino transferases
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This study breaks it down nicely
https://academic.oup.com/endo/article/158/1/56/2751112?login=false -
Prolactin mogs in glucose tolerance tests and this is observed IRL too
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@alfredoolivas Interesting, can you link this study?
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@LunaticRed link above photo
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@alfredoolivas estrogen also helps in glucose intolerance in these models through signalling effects at the pancreas & lipogenesis lowering, so has different signalling ofc but prolactin is probably having estrogen like effects (shares some similar genes activation) (
https://pubmed.ncbi.nlm.nih.gov/12670737/
i read some connection a while back between prolactin and helping slow wave sleep thoughhigh estrogen not good for mood & tumors but good for initial early regeneration, e.g when destroy pancreas cells with a substance or high fat, and lowers lipogenesis in some places so less to deal with on top of the high fat coming in. i guess prolactin shares some of the pathways / gene effects
https://academic.oup.com/endo/article-abstract/150/5/2109/2455831?login=false https://www.jci.org/articles/view/44564so good in those HFD contexts & for that aspect , but when it signals high for a long time it can cause metabolic problems instead "There may be a “goldilocks zone” for serum prolactin that promotes metabolic homeostasis"
in a smaller case control study of 134 patients, the average concentration of prolactin in controls (18.38 µg/L) was found to be significantly higher than that of diabetic patients (5.39 µg/L) (109). Wang et al. also similarly showed that a high normal prolactin range (11.61-26.29 ng/mL) was most protective against insulin resistance and diabetes in a large cohort of patients with hyperprolactinemia
https://pubmed.ncbi.nlm.nih.gov/21557442/ shows high levels create metabolic problems , giving more but not high levels helped
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@cs3000 I agree, the main point of this post was to warn people not to nuke it.
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Human studies
"a 2-3 fold increase of circulating PRL levels maintained for 1.5-3 h exerted no apparent effects on the secretion of endogenous LH, FSH and TSH."
https://pubmed.ncbi.nlm.nih.gov/8258642/"Prolactin does not acutely influence renal electrolyte excretion and probably does not influence water excretion in man."
https://pubmed.ncbi.nlm.nih.gov/870513/ -
Prolactin group had much lower estradiol, but the before measurements were not taken
https://clinicaltrials.gov/study/NCT00438490?tab=results#results-overview
https://pmc.ncbi.nlm.nih.gov/articles/PMC1950489/#sec10
Prolactin group had constantly lower estradiol
Prolactin group ate less
"Short-term prolactin administration causes expressible galactorrhea but does not affect bone turnover:"
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@alfredoolivas so with how good prolactin is, tell us why we shouldn't prolactinmaxx (you know how)
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@engineer I have been doing that with great results.
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thank you all for this incredibly valuable thread. @alfredoolivas thanks for starting it.
I suppose like estrogen, prolactin has its good sides. This has helped me see some more research material I would have missed that I can study.
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After quitting cabergoline, my tiredness has stoppped
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@alfredoolivas at this point I would be worried about not getting in enough food or at least not carb cycling (to lose fat by maximizing carbs only when absolutely needed), because you can feel "not tired" through cortisol which could have been suppressed with cabergoline
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@engineer cabergoline increases noradrenaline though.
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