Fenclonine

alfredoolivas

@hwisdom If i was doing stuff that was good for me, i wouldnt have an account.

hwisdom

@alfredoolivas hahahahahahaha oh wow

engineer

Last one

https://kevinmd.com/2025/11/a-cautionary-tale-about-pramipexole.html

I never thought I’d be the cautionary tale.

For decades, I worked at a financial company. I’m a youth sports coach, a husband, and a father of two. I’ve spent decades coaching, mentoring players, and proudly producing high school sports telecasts. I built a life around leadership, precision, and community.

But none of that prepared me for what happened when I was prescribed pramipexole (Mirapex) to treat Parkinson’s.

The warnings were there: compulsive behaviors, gambling, and hypersexuality. I read them. I nodded. I thought, That won’t be me.

But pramipexole doesn’t come for you like a thunderstorm. It rewires you slowly. Quietly. It doesn’t feel like addiction. It feels like urgency. Like logic. Like a voice that sounds like your own, telling you this next step makes sense. Until it doesn’t.

I lost control. I made choices that devastated my family. Financial ruin. Emotional collapse. The kind of betrayal that no apology can fix. And when I finally came out of the fog (when I tapered off the drug and the compulsive pull vanished), I was left with the wreckage. The clarity came too late.

Since tapering off pramipexole, the compulsive urge is gone. It’s not dulled. It’s not managed. It’s gone. I don’t feel the same pull, the same irrational need, the same hijacking of my thoughts. That switch, the one that used to flip without warning, is silent now.

But that doesn’t undo what happened.

I sit here now knowing that I have ruined the life of my family. I realize there is nothing I can do to change what my brain did under the influence of that drug. I gambled away everything that would have made a life for my children and my wife. What I’ve done is costing me more than I ever imagined: not just the money I lost, but the tax consequences that may prevent my children from finishing college, and burden my wife for the rest of her life.

And I still have Parkinson’s. That won’t get better. I will need help, help I won’t be able to give myself. And my wife won’t be able to be everything for me or for herself. I fear what that means for her. For us.

I feel useless. Guilty. Ashamed. Like I’ve taken a step backward. But I also know this: I’m not hiding anymore. I’m telling the truth. I’m seeking help. I’m writing every day. And even if I can’t fix what’s broken, I can make sure no one else walks into this blind.

Here’s what I need you to understand: The risks and warnings won’t protect you.

You can read them. You can believe you’re immune. But pramipexole doesn’t ask for permission. It changes how your brain processes risk, reward, and impulse. And by the time you realize something’s wrong, you may already be deep in it.

This isn’t just a medical side effect. It’s a neurological hijacking. And it nearly cost me everything.

If you or someone you love is taking pramipexole (or any dopamine agonist), please don’t dismiss the risks. Monitor behavior. Ask hard questions. Don’t wait for the damage to show up before you act.

I’m not asking for forgiveness. I’m asking for awareness, for accountability, and for a system that doesn’t bury these risks in fine print. And for families to know that if something feels off, it might be more than just stress. It might be the drug.

This is my story. And I’m still living it.

RAY. PEAT. Wonder if he was laden with estrogen and PUFAs!

engineer

The connection between dopamine and serotonin

https://haidut.me/?p=2830

It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa.

Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD)

Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level

Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis

SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS)

Blocking serotonin may treat obsessive-compulsive disorder (OCD)

Drop in dopamine behind giving up

And it goes on and on and on!

https://haidut.me/?s=serotonin

Looks like maybe microdosing a DA could be the way to go?

Edit: Looks like the weird side effects from DAs are truly just a stress response?

https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/

engineer

@alfredoolivas said in Fenclonine:

Watch engineer smash all the tortas in Miami now

Speak of the devil except not in Miami

alfredoolivas

@engineer I’m sure the taladafil came in handy

engineer

@alfredoolivas it hasn't quite happened yet but could soon.

hwisdom

selegiline is btw rlly goated it does live to the hype, better than bromantane imo

alfredoolivas

@engineer inshallah

engineer

If pramipexole doesn't work out, it looks like you can also increase dopamine and (hopefully) lower serotonin through MCR agonism. That would mean a peptide like melanotan 2 or PT-141. I already have some melanotan 2 but the jury is still out on melanoma risk so that means PT-141.

engineer

Looks lik maybe MCR agonism is akin to a stress response?

Appears as though metergoline is the way to go even though it mostly works on serotonin

Now the challenge is finding bulk metergoline

hwisdom

@engineer melanotan makes you black through NO stimulation btw, this is why it also gives u massive boners, prolactinogenic, not peaty, fuck melanotan all these mechanisms abt it are just speculations because "erm akshually melanin good!", didnt peter thiel like fund these popular peptides or smth idfk

hwisdom

@engineer metergoline is goated, any chinese nigga on echemi would sell it to you for around like 400$ a gram, 4mg a day for me gave me all the famous benefits of blocking serotonin at a significant rate, but if you can try getting ur hands on the brand name Liserdol product, its gonna be much easier

engineer

@hwisdom it doesnt specifically touch NO, it just stimulates melanocytes through mc1r which is normally agonized by alpha msh, and NO increases mc1r expression like you would expect in a stress state

https://grok.com/share/c2hhcmQtMw_7fd6d676-eb61-41b6-8bff-c75dc29acb22

remember, iNOS is bad and eNOS is fine

engineer

@alfredoolivas said in Fenclonine:

@engineer inshallah

I just gave mami a Ray Peat starter kit

alfredoolivas

@engineer you don’t cheap out, I like it

hwisdom

@engineer I eat out my dogs asshole

jamezb46

@engineer Maybe you would like Bupropion for this purpose. It's easily available.

hwisdom

@jamezb46 it blocks serotonin like that???

jamezb46

@hwisdom It doesn't block serotonin but it increases dopamine and as Georgi has written many times whenever dopamine increases serotonin tends to decrease because of enzyme competition. There are exceptions but in general the above is true as a rule.