Trying this again: Progesterone/Pregnenolone - gut paralysis
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I should also mention that this is a reproducible effect that occurs every time I try prog/preg. Generally, once I get over it I'll wait a few months and work on my digestion and once it's in a good place I'll give it another try and then invariably none of my efforts have made a difference. Probably 4-5 cycles of this at this point.
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worth noting that I've had no such reaction to DHT, Proviron, Anavar, DHEA, 7-KETO-DHEA, testosterone itself, or any steroid that isn't progesterone or a precursor.
Does this not point to cortisol as the sole and only remaining other suspect?
causing swelling/water retention in my intestines
That would be intestinal "pseudo-obstruction".
B.) some kind of vagus nerve or autonomic dysfunction that's worsened by progesterone's anticholinergic effect?
It's called gastroparesis and dysmotility. Gastric emptying is cholinergic.
GABA and alpha-GPC. Stimulators of ICC interstitial cells of Cajal, specifically stimulators of CaCC calcium-activated chloride channels and CFTR as e.g. quercetin or kaempferol.
There are authorized pharmaceutical peristalsis inducers as well via the serotonin pathways and of course simply the antidopaminergic anti-emetics.thiamine, b5, b6, b2 - no effect
B12 and B6 and folate would be the missing basics for nerves.
Wth are you even trying to push prog and preg in the first place?
using hCG for neurosteroids/upstream quite frankly sucks balls.
Is this neurosteroid connection in any way any tangible issue or merely vague and wild RPF-induced conjecture? The latter appears not unlikely given also the outright destructively naive antibiotics regimens. Wth
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@CrumblingCookie naltrexone can also clear the gut out
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Nicotine (unfortunately) with coffee (decaff or caff) & magnesium sulfate (10g) is a temporary fix.
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@alfredoolivas Nicotine doesn't work I'm using it anyway unfortunately. I'm put off from osmotic laxatives generally they don't work much but I haven't tried sulfate.
@CrumblingCookie I'll bite as you seem to know what you're talking about.
Is this neurosteroid connection in any way any tangible issue or merely vague and wild RPF-induced conjecture? The latter appears not unlikely given also the outright destructively naive antibiotics regimens. Wth
The reason I want neurosteroids is because I am on medically necessary TRT (I have secondary/pituitary hypogonadism, my balls work) - If I don't take HCG I become anhedonic despite high doses of test/DHT - prog/preg rapidly relieve this condition I assume by becoming allopregnanolone or something similar. 3a-DHP as well though that has the same problem I assume by converting back into progesterone/5a-DHP (I think this is possible)
I don't disagree that the antibiotics were dumb, looking back it had no positive effect apart from clearing some eczema, and no effect on my gut whatsoever.
B12 and B6 and folate would be the missing basics for nerves.
I take methylfolate for MTHFR. It definitely has a positive effect. I could probably stand to get more B6 & B12, but truthfully I'm at the stage where it's hard to believe B vitamins are the bottleneck.
It's called gastroparesis and dysmotility. Gastric emptying is cholinergic.
GABA and alpha-GPC. Stimulators of ICC interstitial cells of Cajal, specifically stimulators of CaCC calcium-activated chloride channels and CFTR as e.g. quercetin or kaempferol.
There are authorized pharmaceutical peristalsis inducers as well via the serotonin pathways and of course simply the antidopaminergic anti-emetics.Are these recommendations? Supplemental choline has not seemed to help much, though I haven't tried alpha-GPC specifically. Nicotine generally does help my motility but when I introduce prog/preg it seems cancelled out.
Does this not point to cortisol as the sole and only remaining other suspect?
Is it possible I'm high cortisol though I have no symptoms that would suggest it? I don't have a puffy face, I don't gain fat in areas which would suggest it, nor am I overweight. I eat a very high carbohydrate diet.
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@sunsunsun have you used it for this purpose?
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Progesterone can blunt the actions of prokinetic hormones:
reduces the release or the action of motilin, a key initiator of the migrating motor complex
ghrelin signalling, which normally promotes gastric emptying.
Progesterone upregulates neuronal nitric oxide synthase (nNOS) in the enteric nerves.
more NO means more relaxation and less propulsion.
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@wester130 Right. I understand this. My question is how it is that this is so pronounced and intolerable for me whereas others seem to be able to run progesterone without much issue in this regard.
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@jimmynelson pre-existing estrogen issues
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@jimmynelson no but it does work for opioid addicts with constipation (not naltrexone, the modified one that only stays in the gut or else they'd have a really bad time if it absorbed systemically)
secondly, idk if you're taking thiamin hcl, but maybe try benfotiamine. the latter works for my dog if I notice she is a little slow poopy-wise. maybe thiamin hcl isnt strong enough or smth idk
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I think it has to do with bile flow issues /cholestasis.
IIRC a progesterone metabolite is implicated in pregnancy induced cholestasis.
"Significantly less hepatic bile partitioned into the gallbladder in progesterone-treated than in control animals."
https://pmc.ncbi.nlm.nih.gov/articles/PMC1191632/Ive had similar issues in the past when taking pregnenolone and progesterone.
Id try some things that help with cholestasis like TUDCA, gentian or cascara.
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