Estrogenic effects from t3 and progesterone
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@vocedilegno I agree with this here. Don’t supplement it if you’re getting adverse reactions. Find what works. Maybe low dose Niacinamide if your trying to get your temps up
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@Jakeandpace I had thought of Niacinamide and had meant to include it in my above reply, thanks for that!! As Georgi has shown, Niacinamide is a great fatty acid oxidation inhibitor. FWIW I’ve had amazing results with higher doses, 500mg (Thorne brand).
@pineapple WARNING: I can imagine a situation where if you take Niacinamide WITH T3, blocking fatty acid oxidation, and also opposing the effects of cortisol, you could have a hypoglycemic crisis and become very uncomfortable in not even the worst case. So be careful. I’m thinking the experience could be similar to when I dropped 12 drops of Pyrucet in my navel in the morning without any food and had the most severe adrenaline reaction I’ve ever had in my life — nuts pulled up so hard against my body and I was panicking like crazy. Or it could be like the bodybuilders who die of hypoglycemic coma from taking insulin not knowing they have to eat carbs when they inject it.
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@Verdad I thought it was the other way round. Progesterone stops DHEA from converting to estrogen. Progesterone is never converted to estrogen but it can flush estrogen from the tissue into the blood ready to be excreted, if all is working well.
@vocedilegno Do you have a reference for where Dr. Peat said to take beta-blocker with T3? Thanks
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@Peatly I also heard it that progesterone is what prevents estrogenic activity of DHEA, not the other way around. I got the bit about Peat recommending beta blockers for first time T3 use from https://t3uncoupled.substack.com/p/thyroid-supplementation-simplified
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@vocedilegno Thank you.
Do you know which Ray Peat source the quote is from? T3uncoupled has provided 2 references at the end of the article but has not specified which ‘Ray Peat 2021’ this quote is taken from. A search of the newsletters doesn’t yield results for beta blockers (I may not have all the newsletters). It could be from an interview or a personal correspondence. If so, it would be good to get some context. As beta blockers are prescription drugs, it’s possible there was a context specific reasoning behind the recommendation. It is not the usual advice from Dr. Peat for lowering elevated adrenaline.
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@Peatly looking it over again, it does seem that it’s from personal correspondence, doesn’t it. In which case I would agree that it’s likely a very context-specific advice to have the beta-blocker on hand
It’s always seemed clear to me that T3Uncoupled knows and loves Peat’s work more deeply than most of us, and that’s the only reason I didn’t question it or hunt down the primary source.
Corroborating the utility of the idea, a friend of mine experimented with T3 (Cynomel) for his high cholesterol not more than a couple of months ago at my suggestion and had very off-putting heart palpitations. That happened before I had come across the article we’re discussing, perhaps just before T3Uncoupled had published it.
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@Peatly by the way, your signature quote is absolutely fantastic and explains so much about certain people I’ve encountered in my life. Thank you
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@pineapple said in Estrogenic effects from t3 and progesterone:
Anyone else who gets really severe estrogenic effects from small doses of t3 or progesterone? Breast growth (male), edema, immediate gain of pounds of weight (water?), emotional, depression... Even 1 mcg of t3 or just a few milligrams of progesterone causes it and it takes weeks to go away from just a single dose of either one
why is this happening? any input appreciated
I have experienced that and I am relatively certain that this has to do with suboptimal liver function.
I still experience edema , mood swings and depression when I mess up my T3 dose or liver function.
The "Peat diet" is great with a good liver ,but can lead to weight gain and other issues quickly, when liver function is suboptimal.BTW I had to start out with 0.1mcg of T3 because that was all I could tolerate. And even that I could only tolerate after I had lost 20kg which leaned out my liver.
Thyroid requirements can vary drastically. -
@Mauritio what did you do to tolerate t3? Im skinny but cant handle even a dose smaller than what you mentioned, get same side effects. Now that you tolerate it better, what benefits is it giving you? did you solve any health problems with using t3? The whole idea from what I read is it should reduce estrogenic symptoms and edema, so I can't really figure out how it does the opposite in some people
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@pineapple I think you should narrow it down if it was the t3 OR the progesterone. It's very unlikely that both caused the same thing.
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@tubert I have tried them separately with months apart (not taken together). Both produces immediate weight gain, edema, bloating, and the other symptoms I wrote. Small differences exist in how they feel, but my main point is, what is the reason they can produce symptoms that look like high estrogen, when they are supposed to lower water retention, estrogen...
Do most people just get the expected effect where it lowers estrogen symptoms?
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@pineapple from what I have read in the literature, if you have a calcium deficiency, progesterone can cause undesirable effects such as estrogen dominance
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@pineapple said in Estrogenic effects from t3 and progesterone:
@Mauritio what did you do to tolerate t3? Im skinny but cant handle even a dose smaller than what you mentioned, get same side effects. Now that you tolerate it better, what benefits is it giving you? did you solve any health problems with using t3? The whole idea from what I read is it should reduce estrogenic symptoms and edema, so I can't really figure out how it does the opposite in some people
For me it was improving liver health by loosing weight.
It increased my life quality a lot: increased energy while lowering adreanline, increased calories I could eat by about 20-30%, increased mood, lowered edema, better hormonal health, etc... all of those and probably more.
It gives you the estrogenic symptoms because it is not beeing metabolized properly. Im not sure what exactly it is, but too much T3 gives me hypothyroid symptoms and that seems to be happening to you, too. (Maybe its reverse T3?)
Thats why Ray was often talking about the RIGHT amount of thyroid that will do xyz, because the wrong amount can either cause no improvement or even worsening. T3 dosage is not easy to figure out for some people. -
@vocedilegno said in Estrogenic effects from t3 and progesterone:
@Peatly looking it over again, it does seem that it’s from personal correspondence, doesn’t it. In which case I would agree that it’s likely a very context-specific advice to have the beta-blocker on hand
It’s always seemed clear to me that T3Uncoupled knows and loves Peat’s work more deeply than most of us, and that’s the only reason I didn’t question it or hunt down the primary source.
Corroborating the utility of the idea, a friend of mine experimented with T3 (Cynomel) for his high cholesterol not more than a couple of months ago at my suggestion and had very off-putting heart palpitations. That happened before I had come across the article we’re discussing, perhaps just before T3Uncoupled had published it.
T3uncoupled does seem passionate about Ray’s work. This is a good thing.
Your friend’s heart palpitation could be a result of the sudden demand on magnesium induced by taking thyroid. Dr. Peat has spoken about this often:
"Traditional thyroid doctors like Broda Barnes usually started with 30 milligrams of a well-standardized product, like at that time it was Armour thyroid. But I have seen two people who reacted very surprisingly to 15 milligrams, a fourth of a grain, with heart pain, and I realized what's happening is that your cells, especially your big muscle cells, retain magnesium and calcium in a balance. Calcium is a relaxant, and thyroid is needed for the muscles to retain the proper amount of magnesium, and your heart has that same magnesium-retaining, stabilizing effect when your thyroid is good. But if you're suddenly increasing the thyroid when you've been deficient, your muscles, your leg muscles will compete with your heart muscles for that trace of magnesium in your diet, and your heart arteries will constrict and you'll get a heart pain. So it's very important to make sure that your diet includes plenty of magnesium when you're starting to use thyroid." Ray Peat
Magnesium controls autonomic dysfunction by reducing adrenaline release. Ref
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@vocedilegno said in Estrogenic effects from t3 and progesterone:
@Peatly by the way, your signature quote is absolutely fantastic and explains so much about certain people I’ve encountered in my life. Thank you
Dr. Peat was aware of the absurdity of science – ‘the science’ a la Fauci is a good example. I think his sense of humour kept him sane. I will leave that signature here because when I change it, again, it will disappear from my posts.
"Humour is something that is lacking in ordinary science. They can't afford the amount of truth that's needed to experience humour." Ray Peat
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@Peatly thank you so much
