Studies showing cancer reversal / shrinking
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Just noticed these replies @DavidPS @Mauritio William koch only used it for 1 or a few injections mostly (combined with protein aka methionine restriction while its doing its thing to boost response further) . So orally is extending things for lower potency over a longer time. doesnt sound like something beneficial to use generally at these amounts, but specific for outweighing effect on tumors (& other dysfunctions by the book) that looks profound. thanks something to weigh with diabetes, if the need to deal with tumors outweighs or if it can be offset at wounds locally e.g using co2 baths potentially. (radiation / chemo is probably not good for diabetic wounds either)
in the animal study below showing 80% complete remission (amazing result u dont see elsewhere, or without extreme toxicity) they tested high doses for 1 month on various animals. no significant detriment in behaviours, or toxicity to reproductive system, had healthy offspring, organs tested were fine
when they injected it they had initial pain, and eventually some swelling until 10 days after treatment ended (possibly repeat injections?).
So on the macro level at least looks safe enough in general condition considering results for 1 month, but with some proinflammatory effect. But this one, weirdly using much lower dose, but for longer at 6 weeks, showed impaired wound healing and some detrimental measures doi.org/10.1042/CS20050026 and over months showed kidney changes https://pubmed.ncbi.nlm.nih.gov/9740317/
whether creatine can protect from these changes too outside of the heart e.g in kidneys, not suremy take on that is the large doses arent showing much toxicity so seems its based on duration, seems to me its the proinflammatory effect building up creating damage over time
- Btw with right approach it might not need to be used for over a month. Not sure but it showed effect at 10 days in the animal study but that was before it was established. The human study didnt use creatine to boost the effect further. and theres curcumin which might make it more effective too. thats if using orally
@Mauritio 80% complete remission in animal study when vitamin C + creatine was added too
https://pubmed.ncbi.nlm.nih.gov/16112157/the creatine is there for extra safety for the heart and for some reason boosts the effect further
However, in all the normal types of cells tested, methylglyoxal was found to inhibit mitochondrial respiration in only cardiac cells. Creatine, which is abundantly present in these cells, could completely protect against the inhibitory effect of methylglyoxal
& dehydyroascorbic acid form of Vit C is another thing with 2+ carbonyl groups so there to boost effect at decent doses like 500mg+, im guessing it will go up with the ascorbic intake. like taking ubiquinol raises ubiquinone (actually raises ubiquinone more than taking ubiquinone)
both methylglyoxal and methylglyoxal plus ascorbic acid treatment had significant inhibitory effect on cell proliferation. Moreover, treatment of methylglyoxal plus ascorbic acid plus creatine not only completely inhibited the cell proliferation but also made the peritoneal cavity completely dry.
human trial is here https://bioenergetic.forum/post/34639
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@cs3000 Nice ! You might want to send this to Georgi , maybe he'll do a small study on it.
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@cs3000 dehydroascorbic acid can be made by taking vit c with methylene blue . the anti cancer effect is pro ROS because cells take up dhaa and in converting it back to vit c it creates ROS which healthy cells have capacity to deal with while deranged cells generally dont so they get killed by autoschizcis mechanism (a specific type of cell death)
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@cs3000 said in Studies showing cancer reversal / shrinking:
William koch only used it for 1 or a few injections mostly (combined with protein aka methionine restriction while its doing its thing to boost response further) .
At what does did Koch use it for injection?
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@Mauritio good idea i sent an email to idelabs
@eduardo-crispino thanks. they used 500mg normal vit c
curcumin inhibits glyoxalase 1 so should boost the effectiveness further (curcumin + vit c + creatine) but also might make normal cells more vulnerable, tho has some anti inflammatory effect too.
https://pubmed.ncbi.nlm.nih.gov/18946510/
good writeup
https://www.cancertreatmentsresearch.com/methilglyoxal/@alfredoolivas his book on archive.org the chemistry of natural immunity has more details