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Studies showing cancer reversal / shrinking

Bioenergetics Discussion
cancer reversal chlorophyll co2
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  • C
    cs3000 @periander345
    last edited by cs3000 Apr 8, 2025, 7:53 PM Apr 8, 2025, 7:51 PM

    @periander345 a bath is ~5g malic acid + baking soda per L water (warm instead of hot is better for more co2) for covering body. tried it in an awkward to reach place on my back with a small round plastic container , sawed 2 slits in it and fed a thin tie through. It feels like an absolutely backward approach lol probably better to just lay back on top of a bowl filled to surface. tried glycerin gel and adding powders but doesnt sustain the reaction in small area
    the co2 direct would probably only apply to tumors near skin level local to application site (they used tumor graft models)

    "world," as a source of new perceptions
    more https://substack.com/@cs3001

    "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

    P 1 Reply Last reply Apr 8, 2025, 11:00 PM Reply Quote 0
    • P
      periander345 @cs3000
      last edited by periander345 Apr 8, 2025, 11:00 PM Apr 8, 2025, 11:00 PM

      @cs3000 hmmm. Very interesting. Could you use something different than Malic Acid? I know people use CA but that stuff is questionable...

      1 Reply Last reply Reply Quote 0
      • M
        Mauritio
        last edited by Apr 23, 2025, 2:42 PM

        Cineol

        https://lowtoxinforum.com/threads/tudca.8954/post-971631

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        1 Reply Last reply Reply Quote 0
        • M
          Mauritio
          last edited by Apr 23, 2025, 2:44 PM

          Diisopropylamine dichloroacetate (DADA)

          Increases oxidative phosphorylation and lowers lacate

          1000014262.png

          https://pubmed.ncbi.nlm.nih.gov/27582548/#&gid=article-figures&pid=figure-2-uid-1

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • C
            cs3000 @cs3000
            last edited by cs3000 May 3, 2025, 2:04 PM May 3, 2025, 1:20 PM

            https://pubmed.ncbi.nlm.nih.gov/15132968/
            https://sci-hub.st/10.1210/en.2004-0079

            440d56e4-bf12-496a-81a4-c285bd472869-image.png
            when Shh path gets increased (like when androgens get depleted, with a delay) prostate cancer grows

            and other tumors like brain tumors ,
            this is grafted on so not the same as being in brain, but a sonic hedgehog inhibitor (yeah its called that) created regression & nearly fully by 20 days.
            https://sci-hub.st/10.1126/science.1073733
            https://pubmed.ncbi.nlm.nih.gov/12202832/
            b53957e6-c820-47bd-a265-f3544e950980-image.png
            e7b5b90c-2d80-4cc4-8769-10a857169625-image.png
            but cyclopamine used has some toxicity concerns its teratogenic causes birth defects during pregnancy. but they said no apparent detrimental effects.

            • Whatever its biological basis, the general requirement for
              Hh pathway activity in medulloblastoma growth represents a
              potential therapeutic opportunity, because cyclopamine and other
              pathway antagonists can be administered in effective doses with no apparent detrimental effects in rodents and other mammals

            orally though stomach acid transforms it so less effective & maybe more toxic https://pubmed.ncbi.nlm.nih.gov/20236786/
            https://pubmed.ncbi.nlm.nih.gov/1144444/
            also sonic hedgehog path is needed for neuron development so use of inhibitors might be a problem if potent https://pubmed.ncbi.nlm.nih.gov/10375501/
            and might be needed for eye damage repair (is in amphibians) https://pubmed.ncbi.nlm.nih.gov/15013805/

            Instead forskolin should work similarly

            rhabdomyosarcoma lines from humans
            on the 2 less aggressive types using high dose forskolin stopped or regressd tumors (but gave ulceration at injection sites so had to be done every 2 days nearby)

            cccb692f-e5aa-446f-8e28-06b96ea7ab8c-image.png

            it should be effective at lowering sonic hedgehog path on lower dose orally through cAMP. but higher doses needed to activate cAMP in hypothyroidism. and for general use it might be anti androgen.

            "world," as a source of new perceptions
            more https://substack.com/@cs3001

            "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

            C 1 Reply Last reply May 15, 2025, 4:23 PM Reply Quote 0
            • C
              cs3000 @cs3000
              last edited by cs3000 May 19, 2025, 12:39 PM May 15, 2025, 4:23 PM

              @cs3000

              Melanoma remission by frankincense (boswellia) oil extract

              big difference in the dose though 300mg/kg didnt get close , 600mg/kg did but i.p which is generally closer to subcutaneous than taking orally unless oral bioavailability is high.

              they dosed once every 2 days

              they used Boswellia sacra type not Boswellia serrata
              https://pmc.ncbi.nlm.nih.gov/articles/PMC6544398/#s2
              2da52443-81e5-4e08-9da6-429c955ec31c-image.png

              Boswellia serrata trailed on people with brain tumors for lowering edema (less concentration gets there for the full anti tumor effect probably, or different type)
              https://pubmed.ncbi.nlm.nih.gov/21287538/

              In the patient with the highest BS serum levels (5
              samples, all positive with an average KBA concentration
              of 123.1 ng/mL [range, 53.25-153.49 ng/mL]) one of the
              largest edema reductions was observed. His edema volume
              was reduced by more than 300 mL from baseline to the
              time after radiotherapy

              Progression-free survival, which could be a parameter for an antitumor effect of BS, did not differ between the 2 groups

              In the placebo group, 18% of patients had progressive disease (PD), 36% stable disease (SD), 36% partial response (PR) and 10% complete response (CR). In the BS group, 0% had PD, 62% had SD, 25% had PR, and 13% had CR.

              Progression free survival didnt differ , but the boswellia group 0% had progressive disease? so i guess they still died with the non progression because enough tumor was there?

              They used 4200 mg/day split into 3 times a day at 85% acids. 1.2g of boswellia acids at a time * 3

              In the BS patients, tumor volume (biggest lesion) changed from an average of 24.4 cm3 before radiotherapy to 2.9 cm3 after radiotherapy compared with 19.9 cm3 to 16.1 cm3 in the placebo group


              Using boswellic acids orally in rats it only worked before the tumor was established. https://sci-hub.ru/10.1023/a:1006387010528
              cab33f54-58d3-4079-967f-a1e62691a743-image.png

              In the first study the Boswellia sacra type might be less toxic to dose high than serrata which has more a-thujene (not thujone though)
              They look mostly similar in boswellic acids ratios apart from sacra had much more AKBA too https://pmc.ncbi.nlm.nih.gov/articles/PMC6273064/#sec2-molecules-21-01329
              BUT
              Looking around ive seen some analysis of boswellia sacra showing 70% a-pinene instead of boswellic acids
              https://ultranl.com/frankincense-essential-oil-chemotypes/

              So different extraction methods give either high % boswellic acids or high % a-pinene for the sarca type

              and another study the first authors did used an extract mostly a-pinene https://www.sciencedirect.com/science/article/pii/S2221169115001446

              so this study was on a-pinene from Oman boswellia

              It is well established that the principal component of FEO is α-pinene with other terpene mixtures

              Not sure if this high amount would be safe to take orally in grams, sounds like it though (likely potent GABA effect though)

              Terpenes can be irritants at least mildly so probably a good idea to dilute in some oil

              i think its got good absorption % orally,
              i.p administration still goes through metabolism in the liver if other metabolites play a role or cause lowered amount

              Mastic gum / resin or its oil is high in a-pinene >50% (not its leaves)

              ~800mg hits ~900ng/ml in humans and its the free form found too
              https://pmc.ncbi.nlm.nih.gov/articles/PMC7466295/

              Some problems: pinene might have a lot smaller half life in humans than rats,
              maybe some potential for toxicity in high doses or inhaled but idk how relevant https://pmc.ncbi.nlm.nih.gov/articles/PMC9298155/#S15

              • Certified Hojari grade Boswellia sacra gum resins were obtained from the local market. Essential oil was extracted by hydrodistillation method as described earlier [24]. Briefly, Boswellia sacra resins were loaded into 55° C water with a ratio of 1:2.5 (w/v), and mixed with an electromechanical agitator for 30–45 min or until a thick homogenous mucilage was formed. Temperatures of the hydrodistiller were monitored by an infrared thermometer; and pressures were recorded at the condenser terminal. To remove any residual water, collected Boswellia sacra essential oil (FEO) was immediately transferred into a –20° C freezer; and ice crystals were separated from the essential oil.

              • Histological studies revealed that tissue sections from FEO-treated animals did not indicate any detectable pathologic abnormalities as examined by H&E staining. The liver showed normal hepatic lobular architecture, intact central vein with trapped red blood cells in a liver section from FEO treated animals

              • To determine whether 1200 mg/kg body weight of FEO treatment elicits changes in body weight and toxicities to normal major organs, we examined brain, heart, liver and kidney of treated and untreated groups of Swiss albino mice. Histological sections of these tissues from FEO treated mice did not show any detectable pathologic abnormalities as examined by H&E staining

              • Treatment with FEO (250 and 500 mg/kg body weight) reduced elevated levels of AST and ALT induced by acetaminophen administration

              (so showed liver protective effect even at the high dose, but by itself by the images looks like it had some extra liver burden, that didnt progress to significant abnormalities yet, in a toxicity study 2000mg/kg of 100% a-pinene killed the rats but 300mg/kg didnt

              "world," as a source of new perceptions
              more https://substack.com/@cs3001

              "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

              1 Reply Last reply Reply Quote 0
              • C
                cs3000
                last edited by May 15, 2025, 5:19 PM

                updated the last post

                "world," as a source of new perceptions
                more https://substack.com/@cs3001

                "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                1 Reply Last reply Reply Quote 0
                • M
                  Mauritio
                  last edited by May 15, 2025, 7:34 PM

                  I found some terpenes in this shop among them a-pinene and phytol. Not sure if they're food grade , but seems like it.

                  https://goldcoastterpenes.com/shop/terpene-isolates/alpha-pinene/

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  C A 2 Replies Last reply May 16, 2025, 8:06 AM Reply Quote 0
                  • C
                    cs3000 @Mauritio
                    last edited by May 16, 2025, 8:06 AM

                    @Mauritio good price thanks, i found some b-pinene which has similar effects in vitro (sometimes more potent than a-pinene sometimes not).
                    the positive (+) enantiomeric form of these might be more potent
                    b-pinene not a tumor study but used 200mg/kg orally in rats https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.076020

                    "world," as a source of new perceptions
                    more https://substack.com/@cs3001

                    "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                    1 Reply Last reply Reply Quote 0
                    • C
                      cs3000 @cs3000
                      last edited by May 21, 2025, 5:45 PM

                      starting after tumors already established
                      Lemon + Ginger created breast tumor regression
                      https://pmc.ncbi.nlm.nih.gov/articles/PMC9043650/
                      the treated group had much smaller tumor weight initially

                      wamidh talibs research on tumors with natural compounds over past 10 years with great results,

                      https://doi.org/10.1016/j.nut.2017.06.015 in this one lemon alone at higher dose 50mg/kg in mice (as extract, from dried fruit and peel) gave -83% reduction in tumor size (not reduction in growth, regression from initial size it shrunk that much, in 14 days 🔥

                      , all groups had similar initial tumor size, (controls showed 30% without tumors probably showing the initial tumor didnt establish in these)
                      cf05972e-3bad-4f7c-a7bd-80de8244a352-image.png

                      "world," as a source of new perceptions
                      more https://substack.com/@cs3001

                      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                      1 Reply Last reply Reply Quote 0
                      • C
                        cs3000
                        last edited by 17 days ago

                        (important context for this 1)

                        60mg/kg succinate orally shrank liver tumors https://www.cell.com/iscience/fulltext/S2589-0042(24)02958-4

                        b88af704-599f-4783-b8c2-b2c083a2a24a-image.png

                        Succinate also decreased tumor incidence (3/6 mice in the succinate group vs. 6/6 mice in the PBS group, p < 0.01), tumor number (p < 0.01), and tumor load
                        , succinate also significantly suppressed the growth of subcutaneous PLC/PRF/5 xenografts (p < 0.01) and tumor weight

                        Vitamin E succinate didnt work well in ovarian https://pmc.ncbi.nlm.nih.gov/articles/PMC8176246/#sec11 can be high expression of SUCNR1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7488939/ (but a dataset i saw showed similar between liver & ovarian?)

                        ,

                        • the context is SUCNR1 was low in the liver. So it only applies to tumors with low SUCNR1

                        Otherwise adding succinate / activating SUCNR1 more = increased metastasis

                        e.g lung cancer

                        In lung cancer, succinate derived from the cancer cells activates the SUCNR1 receptor and facilitates tumor metastasis through the PI3K/AKT pathway
                        However, data from The Cancer Genome Atlas (TCGA) indicate that SUCNR1 expression is considerably decreased in liver cancer, suggesting a distinct role for succinate in liver cancer.

                        Succinate binding to SUCNR1 activates several signaling targets, notably mitogen-activated protein kinases (MAPKs), and increases intracellular calcium and prostaglandin E2 (PGE2)
                        Succinate induced migration of LLC, A549, PC3, and HT-29 cells, which was blocked by antiSUCNR1 antibodies but not control IgG antibodies
                        . Furthermore, succinate induced invasion of LLC and HT-29 was similarly inhibited by SUCNR1 antibodies
                        succinate induces HIF-1a expression in a SUCNR1-dependent manner
                        Our results show for the first time that serum succinate concentrations are elevated in patients with lung cancer when compared to healthy subjects
                        2fc036f2-1401-451c-9adc-6226f0d01247-image.png

                        • succinate induces HIF-1a and il-6 in macrophages via SUCNR1
                          9206b007-2683-4490-91ea-6c050ad47373-image.png

                        Kidney & lung especially high
                        https://v23.proteinatlas.org/ENSG00000198829-SUCNR1/pathology
                        481f54c5-dfba-4ebd-9d3a-f467721bd28e-image.png

                        regression result worked for liver specifically

                        "world," as a source of new perceptions
                        more https://substack.com/@cs3001

                        "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                        1 Reply Last reply Reply Quote 0
                        • A
                          alfredoolivas @Mauritio
                          last edited by 17 days ago

                          @Mauritio yes, each product has 2 COAs. https://goldcoastterpenes.com/safety/

                          M 1 Reply Last reply 16 days ago Reply Quote 0
                          • M
                            Mauritio @alfredoolivas
                            last edited by 16 days ago

                            @alfredoolivas cool thanks

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            1 Reply Last reply Reply Quote 0
                            • C
                              cs3000
                              last edited by cs3000 11 days ago 11 days ago

                              A-pinene
                              200mg/kg mice dose but subcutaneously (orally would be metabolised different, caution needed tho there is a lethal dose)
                              just 2x a week

                              https://doi.org/10.1159/000479863

                              prostate cancer shrank , nearly went
                              53472b60-7292-4c82-8334-e5fa8c987824-image.png

                              one of the studies before using an essential oil 61% a-pinene worked given i.p , for melanoma at 600mg/kg not at 300mg/kg , mice
                              they used it 1 day on 1 day off
                              tolerated well enough with a day off between, for 2 weeks
                              no idea how that compares to oral absorption for this
                              In rats, orally All 3 animals in the high dose group [2000 mg/kg] died 24 hours after dosing. No mortalities occurred in the low dose animals [300 mg/kg] and no treatment-related effects were observed at necropsy.
                              idk how well translates to humans but (orally) in mice none died 2000mg/kg here acutely , and 400mg/kg of alpha or beta pinene was used for 2 weeks for seizures https://doi.org/10.1111/fcp.12416 (might see some liver damage taken daily though which is why i think they did 1 day on 1 day off in the other, showed liver protection). grams might not be tolerated well orally without causing the shits

                              "world," as a source of new perceptions
                              more https://substack.com/@cs3001

                              "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                              1 Reply Last reply Reply Quote 1
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