Studies showing cancer reversal / shrinking
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updated the last post
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I found some terpenes in this shop among them a-pinene and phytol. Not sure if they're food grade , but seems like it.
https://goldcoastterpenes.com/shop/terpene-isolates/alpha-pinene/
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@Mauritio good price thanks, i found some b-pinene which has similar effects in vitro (sometimes more potent than a-pinene sometimes not).
the positive (+) enantiomeric form of these might be more potent
b-pinene not a tumor study but used 200mg/kg orally in rats https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.076020 -
starting after tumors already established
Lemon + Ginger created breast tumor regression
https://pmc.ncbi.nlm.nih.gov/articles/PMC9043650/
the treated group had much smaller tumor weight initiallywamidh talibs research on tumors with natural compounds over past 10 years with great results,
https://doi.org/10.1016/j.nut.2017.06.015 in this one lemon alone at higher dose 50mg/kg in mice (as extract, from dried fruit and peel) gave -83% reduction in tumor size (not reduction in growth, regression from initial size it shrunk that much, in 14 days
, all groups had similar initial tumor size, (controls showed 30% without tumors probably showing the initial tumor didnt establish in these)
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(important context for this 1)
60mg/kg succinate orally shrank liver tumors https://www.cell.com/iscience/fulltext/S2589-0042(24)02958-4
Succinate also decreased tumor incidence (3/6 mice in the succinate group vs. 6/6 mice in the PBS group, p < 0.01), tumor number (p < 0.01), and tumor load
, succinate also significantly suppressed the growth of subcutaneous PLC/PRF/5 xenografts (p < 0.01) and tumor weightVitamin E succinate didnt work well in ovarian https://pmc.ncbi.nlm.nih.gov/articles/PMC8176246/#sec11 can be high expression of SUCNR1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7488939/ (but a dataset i saw showed similar between liver & ovarian?)
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- the context is SUCNR1 was low in the liver. So it only applies to tumors with low SUCNR1
Otherwise adding succinate / activating SUCNR1 more = increased metastasis
e.g lung cancer
In lung cancer, succinate derived from the cancer cells activates the SUCNR1 receptor and facilitates tumor metastasis through the PI3K/AKT pathway
However, data from The Cancer Genome Atlas (TCGA) indicate that SUCNR1 expression is considerably decreased in liver cancer, suggesting a distinct role for succinate in liver cancer.Succinate binding to SUCNR1 activates several signaling targets, notably mitogen-activated protein kinases (MAPKs), and increases intracellular calcium and prostaglandin E2 (PGE2)
Succinate induced migration of LLC, A549, PC3, and HT-29 cells, which was blocked by antiSUCNR1 antibodies but not control IgG antibodies
. Furthermore, succinate induced invasion of LLC and HT-29 was similarly inhibited by SUCNR1 antibodies
succinate induces HIF-1a expression in a SUCNR1-dependent manner
Our results show for the first time that serum succinate concentrations are elevated in patients with lung cancer when compared to healthy subjects
- succinate induces HIF-1a and il-6 in macrophages via SUCNR1
Kidney & lung especially high
https://v23.proteinatlas.org/ENSG00000198829-SUCNR1/pathology
regression result worked for liver specifically
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@Mauritio yes, each product has 2 COAs. https://goldcoastterpenes.com/safety/
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@alfredoolivas cool thanks
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A-pinene
200mg/kg mice dose but subcutaneously (orally would be metabolised different, caution needed tho there is a lethal dose)
just 2x a weekhttps://doi.org/10.1159/000479863
prostate cancer shrank , nearly went
one of the studies before using an essential oil 61% a-pinene worked given i.p , for melanoma at 600mg/kg not at 300mg/kg , mice
they used it 1 day on 1 day off
tolerated well enough with a day off between, for 2 weeks
no idea how that compares to oral absorption for this
In rats, orally All 3 animals in the high dose group [2000 mg/kg] died 24 hours after dosing. No mortalities occurred in the low dose animals [300 mg/kg] and no treatment-related effects were observed at necropsy.
idk how well translates to humans but (orally) in mice none died 2000mg/kg here acutely , and 400mg/kg of alpha or beta pinene was used for 2 weeks for seizures https://doi.org/10.1111/fcp.12416 (might see some liver damage taken daily though which is why i think they did 1 day on 1 day off in the other, showed liver protection). grams might not be tolerated well orally without causing the shits -
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You can vary these terms for many relevant results: