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    Studies showing cancer reversal / shrinking

    Bioenergetics Discussion
    cancer reversal chlorophyll co2
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    • cs3000C
      cs3000
      last edited by

      updated the last post

      "world," as a source of new perceptions
      more https://substack.com/@cs3001

      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

      1 Reply Last reply Reply Quote 0
      • MauritioM
        Mauritio
        last edited by

        I found some terpenes in this shop among them a-pinene and phytol. Not sure if they're food grade , but seems like it.

        https://goldcoastterpenes.com/shop/terpene-isolates/alpha-pinene/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        cs3000C alfredoolivasA 2 Replies Last reply Reply Quote 0
        • cs3000C
          cs3000 @Mauritio
          last edited by

          @Mauritio good price thanks, i found some b-pinene which has similar effects in vitro (sometimes more potent than a-pinene sometimes not).
          the positive (+) enantiomeric form of these might be more potent
          b-pinene not a tumor study but used 200mg/kg orally in rats https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.076020

          "world," as a source of new perceptions
          more https://substack.com/@cs3001

          "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

          1 Reply Last reply Reply Quote 0
          • cs3000C
            cs3000 @cs3000
            last edited by

            starting after tumors already established
            Lemon + Ginger created breast tumor regression
            https://pmc.ncbi.nlm.nih.gov/articles/PMC9043650/
            the treated group had much smaller tumor weight initially

            wamidh talibs research on tumors with natural compounds over past 10 years with great results,

            https://doi.org/10.1016/j.nut.2017.06.015 in this one lemon alone at higher dose 50mg/kg in mice (as extract, from dried fruit and peel) gave -83% reduction in tumor size (not reduction in growth, regression from initial size it shrunk that much, in 14 days 🔥

            , all groups had similar initial tumor size, (controls showed 30% without tumors probably showing the initial tumor didnt establish in these)
            cf05972e-3bad-4f7c-a7bd-80de8244a352-image.png

            "world," as a source of new perceptions
            more https://substack.com/@cs3001

            "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

            1 Reply Last reply Reply Quote 1
            • cs3000C
              cs3000
              last edited by

              (important context for this 1)

              60mg/kg succinate orally shrank liver tumors https://www.cell.com/iscience/fulltext/S2589-0042(24)02958-4

              b88af704-599f-4783-b8c2-b2c083a2a24a-image.png

              Succinate also decreased tumor incidence (3/6 mice in the succinate group vs. 6/6 mice in the PBS group, p < 0.01), tumor number (p < 0.01), and tumor load
              , succinate also significantly suppressed the growth of subcutaneous PLC/PRF/5 xenografts (p < 0.01) and tumor weight

              Vitamin E succinate didnt work well in ovarian https://pmc.ncbi.nlm.nih.gov/articles/PMC8176246/#sec11 can be high expression of SUCNR1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7488939/ (but a dataset i saw showed similar between liver & ovarian?)

              ,

              • the context is SUCNR1 was low in the liver. So it only applies to tumors with low SUCNR1

              Otherwise adding succinate / activating SUCNR1 more = increased metastasis

              e.g lung cancer

              In lung cancer, succinate derived from the cancer cells activates the SUCNR1 receptor and facilitates tumor metastasis through the PI3K/AKT pathway
              However, data from The Cancer Genome Atlas (TCGA) indicate that SUCNR1 expression is considerably decreased in liver cancer, suggesting a distinct role for succinate in liver cancer.

              Succinate binding to SUCNR1 activates several signaling targets, notably mitogen-activated protein kinases (MAPKs), and increases intracellular calcium and prostaglandin E2 (PGE2)
              Succinate induced migration of LLC, A549, PC3, and HT-29 cells, which was blocked by antiSUCNR1 antibodies but not control IgG antibodies
              . Furthermore, succinate induced invasion of LLC and HT-29 was similarly inhibited by SUCNR1 antibodies
              succinate induces HIF-1a expression in a SUCNR1-dependent manner
              Our results show for the first time that serum succinate concentrations are elevated in patients with lung cancer when compared to healthy subjects
              2fc036f2-1401-451c-9adc-6226f0d01247-image.png

              • succinate induces HIF-1a and il-6 in macrophages via SUCNR1
                9206b007-2683-4490-91ea-6c050ad47373-image.png

              Kidney & lung especially high
              https://v23.proteinatlas.org/ENSG00000198829-SUCNR1/pathology
              481f54c5-dfba-4ebd-9d3a-f467721bd28e-image.png

              regression result worked for liver specifically

              "world," as a source of new perceptions
              more https://substack.com/@cs3001

              "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

              1 Reply Last reply Reply Quote 0
              • alfredoolivasA
                alfredoolivas @Mauritio
                last edited by

                @Mauritio yes, each product has 2 COAs. https://goldcoastterpenes.com/safety/

                MauritioM 1 Reply Last reply Reply Quote 0
                • MauritioM
                  Mauritio @alfredoolivas
                  last edited by

                  @alfredoolivas cool thanks

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • cs3000C
                    cs3000
                    last edited by cs3000

                    A-pinene
                    200mg/kg mice dose but subcutaneously (orally would be metabolised different, caution needed tho there is a lethal dose)
                    just 2x a week

                    https://doi.org/10.1159/000479863

                    prostate cancer shrank , nearly went
                    53472b60-7292-4c82-8334-e5fa8c987824-image.png

                    one of the studies before using an essential oil 61% a-pinene worked given i.p , for melanoma at 600mg/kg not at 300mg/kg , mice
                    they used it 1 day on 1 day off
                    tolerated well enough with a day off between, for 2 weeks
                    no idea how that compares to oral absorption for this
                    In rats, orally All 3 animals in the high dose group [2000 mg/kg] died 24 hours after dosing. No mortalities occurred in the low dose animals [300 mg/kg] and no treatment-related effects were observed at necropsy.
                    idk how well translates to humans but (orally) in mice none died 2000mg/kg here acutely , and 400mg/kg of alpha or beta pinene was used for 2 weeks for seizures https://doi.org/10.1111/fcp.12416 (might see some liver damage taken daily though which is why i think they did 1 day on 1 day off in the other, showed liver protection). grams might not be tolerated well orally without causing the shits

                    "world," as a source of new perceptions
                    more https://substack.com/@cs3001

                    "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                    1 Reply Last reply Reply Quote 1
                    • GardnerG
                      Gardner
                      last edited by

                      Youtube Video

                      1 Reply Last reply Reply Quote 0
                      • AmazoniacA
                        Amazoniac
                        last edited by

                        You can vary these terms for many relevant results:

                        • metastasis "complete remission" metabolic | Google Scholar

                        I now have a support page!

                        1 Reply Last reply Reply Quote 0
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