Glucose loading cures everything?
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ALS is the disease of athletes. Why?
Repeated injuries. With each trauma (emotional and mental as well), the body "CUMULATIVELY" downregulates glucose, creating a deficit cascade in the brain. What if we can prevent or even cure, all of the brain diseases with glucose? Since the brain is command central, how many other health issues could also be resolved?"...INCREASED GLUCOSE, transformed into energy, could give people with amyotrophic lateral sclerosis, or ALS, improved mobility and a longer life, according to new findings by a University of Arizona-led research team."
People with ALS use more energy while resting than those without the disease, while simultaneously THEY OFTEN STRUGGLE TO EFFECTIVELY MAKE USE OF GLUCOSE, THE PRECISE INGREDIENT A BODY NEEDS TO MAKE MORE ENERGY. Experts have not known exactly what happens in a patient’s cells to cause this dysfunction or how to alleviate it. “This project was a way to parse out those details,” said Manzo, who described the results, published online in eLife, as “truly shocking.”
"...The study revealed that when ALS-affected neurons are given more GLUCOSE they turn that power source into energy. With that energy, they’re able to survive longer and function better. INCREASING GLUCOSE DELIVERY TO THE CELLS, then, may be one way to meet the abnormally high energy demands of ALS patients. “These neurons were finding some relief by breaking down glucose and getting more cellular energy,” Manzo said."
“The fact that we uncovered a compensatory mechanism surprised me,” Zarnescu said. “These desperate, degenerating neurons showed incredible resilience. It is an example of how amazing cells are at dealing with stress.” The novelty of the findings partially lies in the fact that metabolism in ALS patients has remained poorly understood, Zarnescu said."
(Source: Georgi/Haidut)
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Caffeine adjunct to coffee may suffice, if that's not too "severe". Or something.
And it became a "toxin" to them.
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@evan-hinkle When I was very ill and found Dr Peat 15 plus years ago, I took Cynomel for several years. It may have saved my life, but I still had headaches, brain fog, fatigue, etc. I don't think I'm able to efficiently convert carbs to glucose.
This is only my third day on glucose and I woke this morning feeling pretty good. The experiment continues.
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@evan-hinkle Excellent analysis
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@S-Holmes interesting, did you ever use cynoplus? In my wife’s working with Danny, he suggested that some T4 was supportive of liver health. Your symptoms sound like low blood sugar/glycogen storage symptoms. Glucose to the rescue?
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@evan-hinkle this is not to say, cynoplus to the exclusion of cynomel, but in conjunction with.
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@evan-hinkle I take a 4 mcg dose of Idealabs Tyronene daily now. But nothing I have done seems to help as much as glucose (so far).
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Wouldn't you get thiamine deficiency from eating pure dextrose?
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@Insomniac said in Glucose loading cures everything?:
Does anyone have an opinion on that woman from the case study eating 2lbs of sugar/glucose on top of her regular diet for 5 months? Can that be right?
@Insomniac said in Glucose loading cures everything?:
By 5 th appointment she was taking between 200 and 240 grams 4 times per day, which eliminated all symptoms. She continued on this dose for 5 months, at which time all symptoms had been eliminated for a month and she discontinued use of glucose apart from occasional doses of 20 to 40 grams during times of high stress. Neuropsychological test scores at the time of completion of treatment ranged from the 84 th to the 97 th percentile.
How did a 63 year old woman eat that much for 5 months? Eating nearly 3200 cals of dextrose powder per day and she's certainly diabetic after 5 months. It's not impossible but it's hard to imagine a doctor telling someone to gain weight like that.
Seems possible to me, but only depending on a lot of missing information.
They may have been that hungry (and that thirsty) after commencing this "protocol". Discarding most of the calories by polyuria. And all or part of what was being "normalised" was cerebral edema. Without continuing the "regular diet" and drinking more, they may experience osmotic diuresis and weight loss. Possibly. It would mess them up.
If it works, it works. But it seems to me like a very disgraceful way to go about it.
This is all quite interesting none the less. Cardiac, renal and pulmonary function are very interlinked (well, it all is but...).
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They don't like fructose. I wonder why.
And they don't like caffeine. Hmm.
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@Insomniac said in Glucose loading cures everything?:
Can someone who isn't diabetic lose a large amount of glucose through the urine if they take enough?
Yes.
Osmotic diuresis is a "normal" "kind" of "overflow". It's conditional. And there are more reasons than overconsumption for blood elevation in "diabetes".
(More than happy for someone to come in here, tell me I'm wrong and school me.)
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Why does this make sense to me? If, due to repeated stress/aging, the body is no longer able to feed the brain via gluconeogenesis, eating a normal healthy diet, and you must have a fully functioning brain to be well and to restore that vital process, why not deliver pure fuel to the brain to aid recovery? If the brain can't recover, the body will never recover. Now the $64,000 question. Will this therapy actually work? I won't know for sure until I test it out. (Day 5).
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But there's some sort of concert going on.
@ThinPicking said in Are Polls a Good Idea?:
Is it actually possible to substitute in either direction. Maybe just a temporary lack of control and engagement in some. Many ways a person can delude themselves. Misappropriate their condition and capability.
I don't know. So this isn't an objection. I'll be creating some posts on the subject at some point.
https://www.mdpi.com/1424-8220/22/23/9115
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075501/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002343/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.040499
https://www.sciencedirect.com/science/article/abs/pii/S0306987719307145
https://www.sciencedirect.com/science/article/pii/S1568163721002865
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00278/full -
If glucose loading works, it hasn't been properly explained why it works.
When tissues cannot absorb and metabolize glucose, why does glucose loading work nonetheless. Perhaps it's because when blood glucose gets high, it triggers the polyol pathway, where glucose is converted to fructose. Unlike glucose, fructose is more easily absorbed and metabolized by tissues.
The question would arise "Why not simply take fructose? The answer is that fructose feeds gut microbes more readily and this can cause some gut problems.
Still, Stephens only focuses on glucose loading as a simple answer to brain lacking the energy to power itself. At least that is the impression I get, and I did not finish watching the video because I felt it is a waste of time. I felt he owes it to his audience explaining the role of having enough tissue oxygenation to fully use glucose to produce energy. Has he done this? He may know this, but he rather prefers to make his case for glucose loading by oversimplifying the case for glucose loading. He must look down on the mental capacity of his audience. Or he may just be practical, seeing his audience as cretins due to the brain already made inutile by lack of glucose.
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
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@yerrag I don’t have a definitive answer, but in his lectures he suggests that the glucose is digested in the small intestine, (prior to reaching potential issue with microbes in the large intestine-not sure where SIBO would come into play there).
He also mentioned in a lecture that in order to better understand why it works he would need volunteers for spinal taps and one other procedure, (I forget) that obviously no one is volunteering for. I personally wonder if using a radioactive substance in mice would lend any clarity on the how or why?
Personally I’m “lucky” to have suffered with poor dental health for years, and as such as soon as glucose goes in my mouth, my teeth get harder, whiter, and shiny/smooth. I’m not sure if this suggests that uptake or “digestion” is even taking place in the mouth, prior to the small intestine, but it’s what I’m experiencing, so I thought I’d throw it out there.
