Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]

user1

@CrumblingCookie said in Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]:

Thanks @user1. Do you mean dates as in the fruit, like medjool dates? Because of their c. 0.3mg/100gr copper content?
I remember I had sort of kept myself afloat for many months by consuming a few hundred grams of dates every day and had assumed their delayed sugar release and balancing potassium content to be the major reason.

Yes this fruit, yet much softer and moistyer thab typical medjool or dattes

bio3nergetic

@alfredoolivas Progesterone lowers 1,25 as well

BearWithMe

Is it possible to have copper deficiency, but normal levels of serum copper and ceruloplasmin, and serum free copper abnormally high?

bio3nergetic

@BearWithMe estrogen can increase free copper while PUFA can increase estrogenic activity in inducing free copper or directly damaging enzymes related to copper utilization. Free copper is what contributes to toxicity. Total copper in a healthy system is what yields robust copper status.

CrumblingCookie

@BearWithMe Can it be lack of retinols as cofactor for ceruloplasmin synthesis, or general liver damage?

bio3nergetic

@CrumblingCookie yes, liver damage will look like Wilson's in some cases. And Retinol is the rate limiting factor for copper status. Copper becomes very unusable without it.

BearWithMe

@CrumblingCookie Retinol deficiency is very possible, but wouldn't that imply low ceruloplasmin? Mine is right in the middle of reference range (0,22 g/l)

CrumblingCookie

@BearWithMe said in Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]:

Retinol deficiency is very possible, but wouldn't that imply low ceruloplasmin? Mine is right in the middle of reference range (0,22 g/l)

By what I've learnt about copper homeostasis it's not as straightforward with the reference ranges. Cpl 0.22g/l looks alright and not too low yet.
But in various disease states, total copper and Cpl seriously rises. Which is directly associated with higher disease severity and death but appears to me to nevertheless be a necessary function in response to the underlying cause.
If you were to assume that your retinol is low and therefore Cpl not as high as physiologically requested and reflected by abnormally high free copper, you'll co-imply that you have a chronic infection of a likely intracellular kind with impeded autophagic clearance and vice versa.

BearWithMe

@CrumblingCookie Makes a lot of sense, thank you. What kind of infection may cause this? I've had elevated ESR and CRP for no apparent reason pretty much since I was born.

dapose

@cs3000
My thought chain goes like… supplementing D3 raises T4 production in the gut. And not T3. Maybe you are getting too much t4 production going and maybe you have a sluggish liver, not converting to excess t4 to t3, so it gets converted to reverse t3 and your feeling a peculiar form of hypothyroidism.

https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1559608/abstract

Do you take magnesium as well?

https://medicalxpress.com/news/2025-09-magnesium-inhibits-colorectal-cancer-carcinogenesis.html