Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]
-
Apparently, 25D which is the metabolite of D3, inhibits 1-25D production
“...With high dose cholecalciferol therapy... PTH is physiologically down-regulated and therefore the synthesis of 1,25-D and dietary calcium absorption are reduced.” — Vaidya, et al. (2015)" -
Methylene Blue should be able to inhibit 1,25 conversion too if hydroxychloriquine can.
-
@bio3nergetic Interdasting, we should get a list of inhbitors / factors that influence the conversion
-
Thanks @user1. Do you mean dates as in the fruit, like medjool dates? Because of their c. 0.3mg/100gr copper content?
I remember I had sort of kept myself afloat for many months by consuming a few hundred grams of dates every day and had assumed their delayed sugar release and balancing potassium content to be the major reason. -
@CrumblingCookie said in Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]:
Thanks @user1. Do you mean dates as in the fruit, like medjool dates? Because of their c. 0.3mg/100gr copper content?
I remember I had sort of kept myself afloat for many months by consuming a few hundred grams of dates every day and had assumed their delayed sugar release and balancing potassium content to be the major reason.Yes this fruit, yet much softer and moistyer thab typical medjool or dattes
-
@alfredoolivas Progesterone lowers 1,25 as well
-
Is it possible to have copper deficiency, but normal levels of serum copper and ceruloplasmin, and serum free copper abnormally high?
-
@BearWithMe estrogen can increase free copper while PUFA can increase estrogenic activity in inducing free copper or directly damaging enzymes related to copper utilization. Free copper is what contributes to toxicity. Total copper in a healthy system is what yields robust copper status.
-
@BearWithMe Can it be lack of retinols as cofactor for ceruloplasmin synthesis, or general liver damage?
-
@CrumblingCookie yes, liver damage will look like Wilson's in some cases. And Retinol is the rate limiting factor for copper status. Copper becomes very unusable without it.
