Can Someone Explain What Cholesterol Values Should REALLY Be?
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Have you personally used arbs and experienced any side effects? I think it's a given as all pharma drugs have side effects.
When I used a calcium channel blocker and a Cox inhibitor, I was also using a diuretic because a side effect of those drugs was edema. And because I was using a diuretic, I had to take a potassium supplement because I would get cramps. But what I was concerned most about is losing my acid base balance, as a chronically acidic state messes with heart rate and pumping efficiency, and the cell easily takes in more calcium from the ecf as internal calcification builds up towards fibrosis, which beings about degeneration in the liver and kidneys as they garden and shrink.
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@yerrag I experienced no side effects with a ARB except maybe a occasional cough if I remember. I stopped needing it and didn't stop bc of side effects.
The side effect profile for candesartan was the same as placebo in the published trails.
You'll probably need more than one drug to get you systolic under 160
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Thanks for sharing. I hope I won't need to use the ARBs, but it's good to know.
I took the no drug approach towards my high BP as a personal experiment and challenge, just to see how seriously detrimental to my health allowing my bp to be naturally set by my body.
It has been 20+ years of steadily increasing BP , and I show no signs of being negatively impacted by it where it matters most.
I would have fixed it last year, but a cruel twist of fate had me take a cathartic detour last year. I hope to conquer my bp ailment within the year.
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@yerrag said in Can Someone Explain What Cholesterol Values Should REALLY Be?:
It has been 20+ years of steadily increasing BP , and I show no signs of being negatively impacted by it where it matters most.
What about an enlarged heart?
You take self experimentation very seriously. I hope you get your answers before it's too late.
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@Insomniac It's naturally going to be enlarged if that is to be expected from high blood pressure. If it were not, I'd be more worried.
The good thing about high BP is that it gets blood through where it's needed even though my blood volume is low. In an old home with plumbing with low cross sectional area that results in high friction losses, the resulting low flow can be boosted by installing a booster pump.
I'm glad I don't need a booster pump and the flow of blood is sufficient to keep my tissues and organs well supplied with vital nutrients as well as allow waste to be dumped out.
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does your husband take magnesium (and other minerals like potassium) and vitamin e?
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@yerrag i used telmisartan for a couple months once and i didnt notice any sides. it got high BP down really fast and made doing exercise way easier and more enjoyable. i was experimenting with testosterone and then lowered my dose of it and then didnt need telmisartan anymore
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220 to 240 consistently shows lowest all cause mortality.
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@sneedful said in Can Someone Explain What Cholesterol Values Should REALLY Be?:
@yerrag i used telmisartan for a couple months once and i didnt notice any sides. it got high BP down really fast and made doing exercise way easier and more enjoyable. i was experimenting with testosterone and then lowered my dose of it and then didnt need telmisartan anymore
thanks. that's good to know.
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@Ecstatic_Hamster said:
220 to 240 consistently shows lowest all cause mortality.
Do you say so in accordance with this chart of cholesterol levels associated with mortality of different diseases?
@yerrag
I also find calcium-channel-blockers' effects somewhat "unstable" for lack of a better term. Coxibes are certainly toxic. I don't understand the shifts in acid-base balance and intracellular Ca2+ (reacting further to calciumoxalate, I guess?) which you write about. Is that Ca2+ influx simply due to lack of K+ influx in this context? The ARBs lower aldosterone a lot and by this can be sparing potassium iirc.
As for ARBs you probably would need to know that those molecules interact with the VDR, with valsartan, candesartan and especially telmisartan being antagonists to it (or inverse agonists). As for olmesartan's agonistic action on that receptor you can find quotes of Ray Peat saying that that's bosh. Then several years later, in 2021 or 2022, he said something along the line of "there probably is some merit to that idea". Losartan would be neutral on the VDR and give rise to the least impact on immune function. -
Read many studies and yes, around 220 - 240 is the lowest mortality in almost all studies. It begins to fall off around 280.
The lower than 220 is much higher mortality and when you get into 150s, then you are in real trouble.
If your cholesterol is 280 (as mine was) it is a hypo thyroid symptom more than anything else.
