Isoleucine restriction in mice increases metabolic rate and lifespan
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Scientists restricted one amino acid (isoleucine) in mice. This made them eat twice as much, have ~75% less fat mass, and live 33% longer.
https://www.cell.com/cell-metabolism/abstract/S1550-4131(23)00374-1?ref=dailydevbytes.com
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interesting.
googled this:
"Isoleucine and valine inhibited the absorption of leucine, and leucine inhibited the absorption of isoleucine and valine."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265085/#:~:text=Isoleucine and valine inhibited the,of the interfering amino acid. -
@LetTheRedeemed said in Isoleucine restriction in mice increases metabolic rate and lifespan:
interesting.
googled this:
"Isoleucine and valine inhibited the absorption of leucine, and leucine inhibited the absorption of isoleucine and valine."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265085/#:~:text=Isoleucine and valine inhibited the,of the interfering amino acid.That's a really good find.
@Serotoninskeptic Thanks for posting. It's a shame sci-hub doesn't have the paper yet.
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@Insomniac Yes and gelatin just so happens to be deficient in isoleucine as well
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@Serotoninskeptic said in Isoleucine restriction in mice increases metabolic rate and lifespan:
@Insomniac Yes and gelatin just so happens to be deficient in isoleucine as well
It would be hard to follow a diet that restricted. 4oz of cheddar gets you 100% the rda. You'd be up against the target at 1.5oz of hard cheese.
Nuts, seeds, fruit and vegetables. A vegan diet and some gelatin would be the only option for something like this.
