Thymus health
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@cs3000 said in Thymus health:
Looks like the main benefit of the Thymus could actually be from suppressing too much immune damage via t reg cells
That is such an interesting thought. Why wouldnt we have an organ whos purpose it is to dampen excessive inflammation, given chronic inflammation is a part of so many diseases.
Dare to think.
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@cs3000 said in Thymus health:
might be why you see elevated neutrophil:lymphocyte ratio in health problems
I always have high neutrophil:lymphocyte ratio 70:20 but have very good immunity, being very resistant to respiratory diseases such as the flu (and COVID) but maybe this keeps my acquired immune system from being overactive;
but my chronic low grade infection and my having heavy metal toxicity disposes my phagocytic cells (neutrophils and macrophages) to be overactive, and my immune system always being on an alert state helps keep my immune system primed;
but this seem to have a downside as an underactive acquired immune system seems to make me develop more cysts and keloids where the inability of my lymphocytes to kill certain microbes makes the body develop fibrous walls to isolate and wrap these microbes and form cysts, but these cysts are benign though
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@Mauritio said in Thymus health:
@yerrag yeah right and didn't they give cortisone to calm the cytokine storm for COVID ?
was it to calm the cytokine storm as a way to dampen Inflammation? I just know cortisone is used as an anti-inflammatory but don't know the mechanism.
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@yerrag not sure.
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And IIRC theanine is beneficial for the thymus.
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@Johann2547 said in Thymus health:
And IIRC theanine is beneficial for the thymus.
interesting thread. makes me think the thymus, being where t cells mature, gets to have a sizable impact on how our immunity functions, or dysfunctions
For one, it dampens the inflammatory response of the innate immune system, characterized by the heavy involvement of neutrophils and macrophages where phagocytic activity can result in a large amount of collateral peripheral tissue damage from spillover ROS.
And given that the lack to T cells can result in B cells exerting more immune response, the tendency of B cells to generate autoimmune responses is also problematic.
Seems to me that ensuring we have a healthy thymus favoring the calming and moderating influenxe of T cells is not a small matter, and that metabolic health, where the stress hormone has to be kept to a minimum level of production and influence can never be stressed, pun not intended, enough.
I can't help but think of metabolic health being as impactful on our immunity, and this is is but just one example of Ray's dictum that metabolic health drives all other aspects of health in us.
I know I have a very rudimentary understanding of immunity, and I'm just giving an immaturely formed rambling of what I can gather from the musings of @mauritio and @cs3000 and @DavidPS
Please let me know how far off I am and what more you can detract and add to it
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@yerrag - I have never studied any of the biological sciences. But as I get older each year, I am increasing interested in healthspan and mindspan. As far as I can determine, your remarks are spot-on.
I am waiting for the results of the TRIIM-X trial (Thymus Regeneration, Immunorestoration and Insulin Mitigation) mentioned in this paper.
The best way to cure a dietary disease is to improve the diet.
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Thanks David. Looks interesting, but very deep and I wish my mind can ensure the onslaught of very unfamiliar words when reading on immunity down to deep levels.
I am reminded of what Peat had said before about T cells- that if you have a good T-cell response, you really won't need to rely on B-cells for immune protection as much. It is like saying a B-cell response is optional when T-cells are involved in the response. I remember him talking or writing about this at the start of the CoVID years. And in the ensuing two years marked with headlines about COVID, all I could hear was centered on B-cell immunity and ntibodies, centered on viral therapeutics.
The funny thing is that the elephant in the room was always being ignored, in the absence of the mention of the T-cells, such that its importance was being downplayed. It seemed to me the medical response is to trivialize the importance of T-cells to improving our body's response to the putative virus.
I think that beefing up the thymus gland should be the main topic of the COVID response.
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@Mauritio said in Thymus health:
@cs3000 said in Thymus health:
Looks like the main benefit of the Thymus could actually be from suppressing too much immune damage via t reg cells
That is such an interesting thought. Why wouldnt we have an organ whos purpose it is to dampen excessive inflammation, given chronic inflammation is a part of so many diseases.
@yerrag said in Thymus health:
The funny thing is that the elephant in the room was always being ignored, in the absence of mention of the T-cells, such that it's importance was relegated to that of a bit player, inconsequential to improving our body's response to the putative virus.
Seems to me that beefing up the thymus gland should be the main topic of the COVID response. The question of the day.
Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc
and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation
their benefit is mainly in the first 12 hours where theyre supposed to help kickstart the cleanup & repair process then back off (reversing their path back into bone marrow). but in the current state of health its common that they stay chronically activated for days weeks months years . regulatory t cells specifically T Reg cells look key to help resolve that
@yerrag I can't help but think of metabolic health being as impactful on our immunity, and this is is but just one example of Ray's dictum that metabolic health drives all other aspects of health in us.
something that fits with that & the rest, neutrophils dont use mitochondria for energy they basically just use glycolysis (& can create their own glucose in presence of glutamine too, and use fatty acids for some functions like ROS production or possibly switch over to fatty acid use to become more intense, in my experience eating more fat takes high neutrophil damage to an extreme),
BUT unlike neutrophils T Reg cells need mitochondria complexes functioning to enable their immune resolving function"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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@cs3000 said in Thymus health:
Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc
and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation
There is a lot I don't understand about the adaptive immune system and maybe it's this lack of understanding that betrays my view in seeing autoimmunity to be largely involved with B-cells.
In this regard, autoimmunity is not so much different from being very sensitive to stimulus that the immune system wrongly regards something that is endogenous as being foreign.
I have chronic high blood pressure and it is the result of my neutrophils and macrophages of the innate immune system trying to get rid of heavy metal toxins and periodontal infections with no success, given the persistency of these insults where they don't get permanently removed or killed. It is like Groundhog Day for my immune system where they keep repeating their efforts to get rid of persistent insults that keep bouncing back. Yet I do not consider the inflammatory effects of this endless effort to be an autoimmune condition. But I blame the tenacity of heavy metals refusing to be swallowed up and excreted out, and the ability of synergistic bacteria and fungi to defend against attack by phagocyte activity by neutrophils and macrophages.
But lately I have used techniques and substances to assist my immune system to successfully get rid of the hitherto unremovable toxins and immortal infection. But I had to employ medically unorthodox techniques to achieve these.
Seems to me medical complex is guilty of spreading misinformation and disinformation to label as autoimmune, on the strength of their vaunted research which are in many cases made up stories to lead trusting souls astray.
Yet I do not wish to throw the baby with the bathwater, for a large part of the body of research is valid, and a good filter is needed to separate wheat from chaff.
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