Diclofenac gel to regrow hair on bald head and beard

wester130

I have discovered a way to use essential oils without greasiness and made a good recipe

use everclear, and the essential oil, applying it becomes non-greasy

so you could do 28ml Everclear, 1ml peppermint oil and 1ml eucalyptus oil, or your oil of choice

Mauritio

I have looked at miconazole and related anti fungals for hair loss. And I've seen miconazole depicted as androgen-neutral, which does not seem to be the case.
It might not target the androgen receptor, but like all the azoles it inhibits many steroidogenic enzymes. The one of the least issues in that regard seems to be isoconazole.
So I would definitely not take it orally, but also even topically seems risky. Although Wikipedia states that topical absorption is minimal .

Its tendency to inhibit steroidogenenesis, might also be part of the reason it works, it also inhibits the enzyme that converts progesterone to androstenedione, so that could locally increase progesterone in the scalp which is very hair protective .

Mauritio

Here's a new study suggesting topical MUFAs cause regrowth of hair.

It's interesting that only MUFA promoted hair stem cells . SFAs were neutral and PUFAs destroyed them.

There was a study where lard regrew hair that could be the reason why.

It still seems to be downstream from increased ATP, OxPHOS and mitochondria (PHC1a)

So maybe pure oleic acid on the scalp is the way to go ?

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00397-3

Hearthfire

@Mauritio

There was a study in 2013 where a researcher tested pig lard on himself and regrew a lot of hair.

https://cltri.gov.in/Pugazhendan/Beneficial Effect of Lard in Androgenic Alopecia.pdf

The recent study is going viral all over social media. Those amazon oleic acid sellers about to make bank lol.

CrumblingCookie

@Hearthfire said in Diclofenac gel to regrow hair on bald head and beard:

Those amazon oleic acid sellers about to make bank lol.

Just go to your local supermarket to buy high-oleic sunflower seed oil: 88% MUFA, 3% PUFA, 9% SFA.
Why not apply it to your whole bodies and scrape it off for care and cleaning, Roman style.

@Mauritio Does it come down to membrane fluidity as the cause for MUFA improving the ETC?

Mauritio

@Hearthfire yes I mentioned that in my above post. i guess that's the mechanism then. Godd that it's not risky or expensive to try it out.

Mauritio

@CrumblingCookie said in Diclofenac gel to regrow hair on bald head and beard:

Just go to your local supermarket to buy high-oleic sunflower seed oil: 88% MUFA, 3% PUFA, 9% SFA.

They showed that PUFA actually killed the hair stem cells so I'm wondering if the small amount of PUFA in subflower or olive oil would be enough to destroy it. So i do think it's best to go with oleic acid in ethanol to replicate the study.

@CrumblingCookie said in Diclofenac gel to regrow hair on bald head and beard:

Does it come down to membrane fluidity as the cause for MUFA improving the ETC?

No at least i haven't seen that mentioned. It reliant on hair stem cells and on PGC1a which increases mitochondria and eventually ATP.

cookielemons

@Chud said in Diclofenac gel to regrow hair on bald head and beard:

supplementing d3/k2/t3

What doses and forms?

Mauritio

@Mauritio said in Diclofenac gel to regrow hair on bald head and beard:

Here's a new study suggesting topical MUFAs cause regrowth of hair.

It's interesting that only MUFA promoted hair stem cells . SFAs were neutral and PUFAs destroyed them.

There was a study where lard regrew hair that could be the reason why.

It still seems to be downstream from increased ATP, OxPHOS and mitochondria (PHC1a)

So maybe pure oleic acid on the scalp is the way to go ?

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00397-3

Here's a new study on the same subject, also using oleic and palmitic acid.
They find again that both are effective at starting the anagen hair phase in mice.
They also tested lactate, which was ineffective ,although there were some mice who responded well.
They also showed that oleic acid did not stimulate inflammatory cytokines, while palmitate did. This rules out the "stress/inflammation hypothesis" of why oleic acid works.

There's a few points worth mentioning :

We've previously posted study on this thread showing the benefits of lactate for hair growth, this study shows that it inhibits it.
In the other study on oleic acid and hair they said oleic acid induced OxPhos, here they say: ".. the onset of the anagen phase can be stimulated by locally suppressing oxidative phosphorylation in the skin."
They said that some parts of the hair rely on OxPHOS and some on glycolysis. They cited a paper but I haven't looked in it.

They don't talk about oleic acid being more effective than palmitic acid, but the image clear shows it.
a+b = palmitic acid (3 days in between)
c+d = oleic acid (3 days in between)

https://pubmed.ncbi.nlm.nih.gov/40141208/#&gid=article-figures&pid=figure-3-uid-2

Mauritio

I have received my pure oleic acid today. And started applying it already. It feels and looks quite different to olive oil. It smells more like castor oil and the consistency is more watery than I imagined.
It also burned when I applied it to my scalp although that was only where the skin was dry. And a quick Google search said that that's normal for pure oleic acid.
Let's see how it goes.