Diclofenac gel to regrow hair on bald head and beard
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I started my experiment this morning on 2 small bald spots in my beard.
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@wester130 said in Diclofenac gel to regrow hair on bald head and beard:
@Mossy tretinoin isn't a systematic drug so should be okay
https://pubmed.ncbi.nlm.nih.gov/9115052/
https://www.medicaljournals.se/acta/download/10.1080/00015550118916/
https://pubmed.ncbi.nlm.nih.gov/1829464/
It should reduce sebum and force your scalp to generate new skin,
But it all depends on what you think is the cause of balding
Thank you for this info.
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@wester130 said in Diclofenac gel to regrow hair on bald head and beard:
@Mossy tretinoin isn't a systematic drug so should be okay
Wrong. Tretinoin does cause systemic adverse effects. Which can be even long-lasting.
They are simply not publicly acknowledged.
I can't provide the specifics anymore as I once must have written them on paper or tried to remember them in my head. It's not a good ingredient to use IMO. -
@wester130 What % of glycolic acid are you using?
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After some additional research, I'm going to have to count out taking Diclofenac gel for now, based on potential severe stomach issues, such as ulcers and deterioration of the lining.
If I understand these posts correctly, some users of Diclofenac take an additional supplement or drug to counter the lining deterioration, ulcer issue. That seems like a tightrope that would be hard to walk, getting the balance just right. At least for someone highly susceptible to side effects.
https://www.reddit.com/r/ChronicPain/comments/bn7a7z/comment/en3g3zc/
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@tubert 20% is enough to dissolve the top layer of skin
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@wester130 thx! I have that at home, but how long do you leave it on for? I used to use, but after 5 or so minutes my scalp was on fire. So I wasn't sure if thstcwas such a good thing
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@tubert persoanlly i can leave it on overnight but Vitamin A and retinol products may be better to remove old collagen
idealabs sell a Vitamin A product in alcohol so it's not as greasy
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@wester130 ok, thanks for the info! It may be that my scalp just needs to get used to the acid
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actually this has made me reconsider diclofenac
https://www.hairlosstalk.com/interact/threads/diclofenac-gel-oil-prepared-iontoforesis-photos.91503/
in hindsight, When I used diclofenac I used a spray bottle with mint essence, maybe that's what I was reacting to
I may try voltarol gel instead
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That does make me reconsider trying it. Impressive.
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what part of diclofenec causes the growth?
is it the suppression of tgfb-1? just a guess
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@wester130 Powerful anti-inflammatory action. Whatever is going on in the scalp that causes the inflammation, it reduces that inflammation effectively, and allows hair to grow again. Could be the lowering of pgd2.
This post from a thread on hairlosstalk seems to hit the nail on the head
If you look at the mechanism of action, it inhibits cox as most NSAIDs. Means it lowers also the beneficial pge1, pge2 and pgf2a. However bald scalp mostly expresses pgd2 and low pge2, makes sense that there is overall a beneficial effect. Story changes probably once you want actual regrowth, and are already taking finasteride/dutasteride/ru etc and also start more targeting of that pathway (crth2 inhibitors, pge2, pgf2a analogues...). I guess one could in fact try diclo plus topical pge analgues (you probably at least want pge2 analogue plus castor oil and in addition some potent pgf2a like chloprostenol) to avoid this issue and save some money on seti etc (and avoid the non-responder issue with crth2i therapy). I also would avoid diclo while woundling, as inflammation triggers the growthfactors which makes it even less practical as pgd2 and crth2 inhibit wound induced hf neogenesis.
I bet pairing it with castor oil taken orally would be a powerful combination.
The ricinoleic acid in castor oil is a potent pge2 agonist, it stimulates pge2, and potentially has an antagonizing effect with pgd2. Pge2 promotes relaxtion of tissues, pgd2 promotes constriction of tissues.
Good video from More Plates More Dates on the subject:
https://www.youtube.com/watch?v=rOnK9bX5TLMSo you lower the high balding scalp levels of pgd2 with the Diclofenac gel, then take castor oil to promote pge2, and get even more pgd2 antagonist action.
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@Hearthfire it still sounds a dangerous drug
I am consdiering NMN, nicotinamide mononucleotide, seems better than niacinamide
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I did a bit more reading on the side effects, the crazy stuff like heart attacks seems it's related to people taking it in tablet form in fairly high doses, and it's because it raises your blood pressure.
I don't think rubbing the gel on topically would cause an issue, not anymore than nizoral/minoxidil and some of the other things people use topically. Since you can now buy the gel on freakin' Amazon without a prescription, I imagine it's very safe to use topically.
People take NSAIDs all the time that increase the risk of heart attack. Doesn't mean it will. If you're not healthy, by all means avoid it.
