Random, interesting studies
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High salt diet induces muscle loss via cortisol, if simultaneously given saline Solution, not if rats were given tap water.Maybe there's a Sweet Spot for Salt.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409074/Dare to think.
My X:
x.com/Metabolicmonstr -
A sweet spot, a circadian and an infradian. I'll be lucky if I can get there a few times a week because it's a moving target. Unless I do nothing, say nothing, go nowhere and see no one.
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Dates (polyphenols) activate FXR and modulate bile acids.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5749773/ -
Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
https://pubmed.ncbi.nlm.nih.gov/35257010/Chlorogenic acid fed mice increase less in weight than controls mice on a high fat diet. AND weigh less than animals on a normal control diet.
https://pubmed.ncbi.nlm.nih.gov/20064576/Might inhibit Mao a+b
https://pubmed.ncbi.nlm.nih.gov/29893510/ -
I like this thread.
Thank you -
@dapose you're welcome.
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Magnesium Sulphate for "stuck bile" I cholestasis
"Taken together, the results of this study suggest that MgSO4 treatment may be beneficial in cholestasis-induced hepatotoxicity."
https://pubmed.ncbi.nlm.nih.gov/25967882/"Mg SO4 may increase bile secretion and relax the sphincter Of Oddi, resulting in emptying and consequently a reduction of Gallbladder volume"
https://journals.lww.com/ajg/fulltext/2004/10001/the_effect_of_magnesium_sulfate_on_the_human.140.aspxIt increases the discharge of bile
https://pubmed.ncbi.nlm.nih.gov/955499/i was thinking maybe topical application of magnesium sulfate to relax the sphincter of oddi muscle and to increase bile discharge.
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3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-DihydrodiligustilideIt has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.
"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."Dare to think.
My X:
x.com/Metabolicmonstr -
Bloodroot seems to be by far the most potent progestogen they tested. It contains more than 10 times the amount of progestogenic parts than the next most active and it has no estrogenic activity, at least it does not promote cancer growth of estrogenic cancers .
https://journals.sagepub.com/doi/abs/10.3181/00379727-217-44247
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Dates, olives and walnuts contain the highest amounts of the phytoprogestogen syringic acid.
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@Mauritio said in Random, interesting studies:
3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-DihydrodiligustilideIt has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.
"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.
In this review they look at the anti inflammatory effect of it.
