Random, interesting studies

Mauritio

@lobotomize yeah you have a point. Maybe I'll make some of larger posts (like the coca one)into a thread.
When I start I never know what a posts turns out to be, because it depends how much fun it is to research it, so that's why i just drop all the studies here.

Mauritio

Theobromine drastically Upregulated UCP1 AND PGC1a. Only in vitro, set still interesting.
Been wanting to try it for a while .

https://sci-hub.ren/10.1007/s12257-018-0434-y

DavidPS

@Mauritio - Have you considered food sources?

Foods Ranked 1 - 20 With Theobromine

CrumblingCookie

@Mauritio - Have you considered food sources?

Foods Ranked 1 - 20 With Theobromine

My expectations for such a list were low but nevertheless beaten by such impressive stubborness:
It's only variations of cocoa and chocolate!
Now we know of your imaginations of a well-varied, balanced diet. Made me chuckle.

Mauritio

@DavidPS yes, I like chocolate, but it contains too much heavy metals.
Has anybody tried theobromine as a supplement ?

DavidPS

@Mauritio - thank you for bringing theobromine to my attention. I plan on trying it after things settle down after the holidays.

I am anticipating that theobromine will stress my nervous system in much the same way that caffeine stresses it and I plan on timimg my daily doses much like I do with coffee.

Health benefits and mechanisms of theobromine (2024)

Highlights

• Theobromine, a member of the methylxanthine class of compounds, has multiple potential health benefits.

• Theobromine acts as a non-selective antagonist of adenosine receptors, operates as a competitive and non-selective inhibitor of phosphodiesterases, and disrupts the activity of poly(ADP-ribose) polymerase 1 to exert its physiological functions. Theobromine, due to its low toxicity and versatility, can be employed as an additive in functional foods.

LucH

@DavidPS said in Random, interesting studies:

I am anticipating that theobromine will stress my nervous system

Mind theobromine if weak cardia muscle (acid reflux)

Mauritio

@DavidPS you're welcome.
Theobromine is supposed to be less stimulating for the CNS than caffeine.

Here's another study where it strongly increased tyrosine hydroxilase and dopamine receptors in a mouse model of ADHD.

https://www.researchgate.net/publication/380300570_Theobromine_improves_hyperactivity_inattention_and_working_memory_via_modulation_of_dopaminergic_neural_function_in_the_frontal_cortex_of_spontaneously_hypertensive_rats

Mauritio

This post is deleted!

Mauritio

Aspirin alleviates fibrosis in mouse model. Hed~600mg.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12226408/