Random, interesting studies
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@Mauritio said in Random, interesting studies:
ive tried it and it seemed to have a beautifying effect on my face . Skin and hair looked better. Unfortunately it made me gain weight. But a lot of substances do that
I'm all in favor of beautification! Neat.
How much, how many Units of catalase were you taking and for how long? On an empty stomach?
It's strange that there are not published human trials on exogenous catalase.There are two recent studies from 2023 and 2025
wherein the authors complexed the catalase in calcium alginate microspheres, thereby protecting the enzyme from both acidic pH and protein degradation whilst ensuring its release in alkaline pH.
Should be very effective against UC and IBD.As much as I wish I won't be creating alginate microspheres anytime soon. Perhaps there's merit to at least using stomach-resistant encapsulation, though, or alternatively just a stubbornly higher dose.
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@lobotomize said in Random, interesting studies:
haribo and most gummies have beeswax
What other waist products ingredients is there in it?
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@CrumblingCookie yeah it's an interesting substance. It could be useful for hair loss applied topically as well. And probably very good for skin, too.
I don't recall how much I took and it was only for a few days, after which I was certain the weight gain waa from it. -
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis, 2020
Abstract
Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis, but its contribution to macrophage functions and host defense remains to be delineated. Here, we showed that lipopolysaccharide (LPS) in combination with IFN-γ inhibited PINK1-dependent mitophagy in macrophages through a STAT1-dependent activation of the inflammatory caspases 1 and 11. In addition, we demonstrated that the inhibition of mitophagy triggered classical macrophage activation in a mitochondrial ROS-dependent manner. In a murine model of polymicrobial infection (cecal ligature and puncture), adoptive transfer of Pink1-deficient bone marrow or pharmacological inhibition of mitophagy promoted macrophage activation, which favored bactericidal clearance and led to a better survival rate. Reciprocally, mitochondrial uncouplers that promote mitophagy reversed LPS/IFN-γ-mediated activation of macrophages and led to immunoparalysis with impaired bacterial clearance and lowered survival. In critically ill patients, we showed that mitophagy was inhibited in blood monocytes of patients with sepsis as compared with nonseptic patients. Overall, this work demonstrates that the inhibition of mitophagy is a physiological mechanism that contributes to the activation of myeloid cells and improves the outcome of sepsis.This makes it seem that autophagic, specifically xenophagic mechanisms and IFN-y are in stark opposition to mitophagic and uncoupling processes.
I.e. application of enhancers of mitophagy like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. will significantly inhibit innate immunity, and vice versa the (required) activity of immunity unequivocally decreases mitophagy and uncoupling.Which yet again suggests an immunological, infection-driven cause to metabolic diseases.
Taking uncouplers or mitophagy-enhancers therefore would only forcefully override the physiological response state of the body. Putting the cart before the horse.
@mauritio Ever fancied to trial interferon gamma 1b injections s.c. long-term three times weekly? -
@CrumblingCookie said in Random, interesting studies:
Taking uncouplers or mitophagy-enhancers therefore would only forcefully override the physiological response state of the body. Putting the cart before the horse.
Could you help to clarify, please?
If I understand well: Do not stimulate autophagy by xeno-substances but optimize the macrophage action, in order not to dampen the innate immune reaction.
Deduction: And if we want not to forcefully override the physiological response state of the body, we’d better manage the transitory LPS production (help to get rid of, on a fluently manner).
Decode correct? -
@LucH
Yes, do not stimulate the mitophagy branch of autophagy by xeno-substances if the underlying condition is one of innate immune requirements.
But as you point out on the other hand, if such immune activity were to be co-caused by circulation of LPS (yet without bacterial translocation! is that possible ?) then the notorious carrot salad or whatever helps seal the GI barrier would automatically improve systemic mitophagy and uncoupling and metabolism by their decrease of invading LPS.
Yet again in conditions of increased innate immune requirements but of little IFN-y because of intracellularly hiding pathogens (and their downstream counteraction of IFN-y) like chlamydophila or mycobacteria the therapeutic success hugely benefits from stimulation with IFN-y. Hugely! There are studies on that. Such conditions, when latent, contradict excess fat loss and forbid the use of any such substances which promote mitophagy or uncoupling. -
@CrumblingCookie said in Random, interesting studies:
et again in conditions of increased innate immune requirements but of little IFN-y because of intracellularly hiding pathogens like clamydophila or mycobacteria the therapeutic success hugely benefits from stimulation with IFN-y. Hugely!
OK, thanks for the detailed explanation.
Now, if I can abuse (feel free to ignore it if you haven't time to ...)
Above 55 yrs old, nearly every body has brown spots on the skin, of a certain thickness. => HPV.
If you want to get rid of them, you kill them by cryogenics (frozen) or with appropriate essential oils (12 weeks!). In both cases, there will be bacterial residue (LPS). The same thing happens when the immune system gets rid of a cold or the flu...
So, the question is: How to help without stimulating the immune system. Do not answer because I already know the answer. Do not override the immune response with xeno-molecules, but help / assist the system, on an indirectly manner. Said on a different manner: Do not use the hammer when you can assist the body. But there is much more to say ... Not here, OK. Interpretation in the right direction? -
@LucH : Instructions unclear.
feel free to ignore
So, the question is:
Do not answer because I already know the answer.
much more to say ... Not here, OK.
Interpretation in the right direction? -
Very interesting new study.
FGF21 overexpression prevents obesity, liver steatosis, and loss of lean mass in gerobese mice fed a HFD. The muscle preserving effect is interesting. Might be the reason people dont loose muscle when doing methionine restriction."... these mice lived up to 3.3 years, resisted weight gain, improved insulin sensitivity, and showed reduced liver steatosis. "
The mice lived about 25% longer than controls. Just from overexpressing FGF21. Pretty impressive. So life- and healthspan was increased.
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Here's a study showing N-methylserotonin lowers adiposity and increases liver glycogen.
It has similar effects as serotonin hence im surprised that it has these beneficial effects.
It does seem to activate the serotonin auto receptor (which lowers serotonin) and several other serotonin receptors and it also works like an SSRI.
In the above study it increases transit speed. Maybe that was enough to help with metabolism.Anybody have any idea why that happened?
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Agar liberated serotonin and histamine in a normal study.
https://link.springer.com/article/10.1007/BF00537358 -
Frankincense
A Boswell if acid from frankincense increased ATP, PHD, SOD , Catalase and AMPK amongst others in this animal model
https://pmc.ncbi.nlm.nih.gov/articles/PMC10097356/frankincense (Boswellia serrata) oil increased circulating thyroid hormones (T3 and T4), but also GH
https://pubmed.ncbi.nlm.nih.gov/PMC10044135/Boswellia serrata gum extract activates AMPK signaling, reduces mTOR activity, and protects dopaminergic neurons from rotenone-induced neurotoxicity in mice, suggesting a neuroprotective mechanism via energy- and autophagy-related pathways
https://pubmed.ncbi.nlm.nih.gov/35804280/Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio I’m using Boswellia every night before bed with baking soda and glycine water. Most consistent vivid dreams I’ve had as an adult!
It’s a COX enzyme blocker, very good anti inflammatory for me. -
