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Random, interesting studies

Literature Review
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  • M
    Mauritio @alfredoolivas
    last edited by Mauritio Jan 26, 2025, 11:57 AM Jan 26, 2025, 11:55 AM

    @alfredoolivas yeah very interesting!
    Look at the progesterone like effect of the studies I just edited in.
    If they are indeed saturated molecules that makes an estrogenic effect even less likely .

    Btw trump just brought back menthol cigarettes , so that's good timing 😁

    Dare to think.

    My X:
    x.com/Metabolicmonstr

    A 1 Reply Last reply Jan 26, 2025, 12:45 PM Reply Quote 0
    • A
      alfredoolivas @Mauritio
      last edited by Jan 26, 2025, 12:45 PM

      @Mauritio Peppermint oil is 30-50% menthol, 15-30% menthone and 5-10% eucalyptol. So peppermint oil could be a vehicle to deliver these substances.

      M D 2 Replies Last reply Jan 26, 2025, 1:20 PM Reply Quote 0
      • M
        Mauritio @alfredoolivas
        last edited by Jan 26, 2025, 1:20 PM

        @alfredoolivas yes. I'm just not sure about potential estrogenic or anti DHT effects. But I haven't seen anything conving, that would stop me from consuming it infrequently .

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        1 Reply Last reply Reply Quote 0
        • D
          DavidPS @alfredoolivas
          last edited by DavidPS Jan 26, 2025, 1:32 PM Jan 26, 2025, 1:28 PM

          I purposefully stay away from peppermint.

          Effects of peppermint teas on plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels and testicular tissue in rats (2004)

          ““Effective health care depends on self-care” - Ivan Illich, 👀
          ☂️

          M C 2 Replies Last reply Jan 26, 2025, 1:35 PM Reply Quote 0
          • M
            Mauritio @DavidPS
            last edited by Jan 26, 2025, 1:35 PM

            @DavidPS yeah that is the most convincing study i've seen so far the dosage also wasn't excessively high

            Dare to think.

            My X:
            x.com/Metabolicmonstr

            A 1 Reply Last reply Jan 26, 2025, 1:40 PM Reply Quote 0
            • A
              alfredoolivas @Mauritio
              last edited by Jan 26, 2025, 1:40 PM

              @Mauritio Well progesterone does the same; inhibits LH and FSH, and is therefore anti-androgenic. Unless peppermint oil is estrogenic, it may be a good proxy for progesterone.

              M 1 Reply Last reply Jan 26, 2025, 4:05 PM Reply Quote 0
              • D
                DavidPS
                last edited by Jan 26, 2025, 2:27 PM

                a938e388-00c8-4bb1-8b8e-f257e00dbc65-image.png

                ““Effective health care depends on self-care” - Ivan Illich, 👀
                ☂️

                C 1 Reply Last reply Jan 28, 2025, 2:01 PM Reply Quote 0
                • M
                  Mauritio @alfredoolivas
                  last edited by Jan 26, 2025, 4:05 PM

                  @alfredoolivas said in Random, interesting studies:

                  @Mauritio Well progesterone does the same; inhibits LH and FSH, and is therefore anti-androgenic. Unless peppermint oil is estrogenic, it may be a good proxy for progesterone.

                  Peppermint actually increased LH /FSH, unlike Progesterone.

                  I want to mention that the amount of menthol you get from tea is about ten times less than you get from the essential oil. and menthol seems to be the deciding metabolic factor here.
                  menthol actually has antiprolactin effects as i posted above so i'm not sure if anti - testosterone effects would be seen with the essential oil which is mostly Menthol.

                  Screenshot_20250126-165925.png

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • C
                    cs3000 @DavidPS
                    last edited by cs3000 Jan 28, 2025, 2:00 PM Jan 28, 2025, 1:33 PM

                    This post is deleted!
                    1 Reply Last reply Reply Quote 0
                    • C
                      cs3000 @DavidPS
                      last edited by cs3000 Jan 28, 2025, 2:15 PM Jan 28, 2025, 2:01 PM

                      @DavidPS high amounts 40mg/kg peppermint caused white matter dmg vs 10mg/kg which didnt show it for this dmg , rats https://www.sciencedirect.com/science/article/abs/pii/0378427483901212

                      But the menthol has some liver toxicity at dopamine doses i think, shows liver protection caused by other things but can cause liver changes https://doi.org/10.1016/0378-4274(83)90120-0

                      c99b9f92-c87f-4429-8ee2-72bf24dd7d95-image.png

                      when i tried menthol for the dopamine & temp effect i tried it through the skin , noticed some liver pain after a bit ~1g. which i never get otherwise

                      D M 2 Replies Last reply Jan 28, 2025, 7:46 PM Reply Quote 0
                      • D
                        DavidPS @cs3000
                        last edited by DavidPS Jan 28, 2025, 7:47 PM Jan 28, 2025, 7:46 PM

                        @cs3000 - thanks for the additional information.

                        ““Effective health care depends on self-care” - Ivan Illich, 👀
                        ☂️

                        1 Reply Last reply Reply Quote 0
                        • M
                          Mauritio @cs3000
                          last edited by Mauritio Jan 28, 2025, 7:52 PM Jan 28, 2025, 7:52 PM

                          @cs3000 thanks interesting . It seems save enough for a short duration or infrequent use.
                          I also noticed some dopaminergic benefits from nebulizing peppermint oil . I guess the dose there should be very low.

                          The liver pain might also come from it decreasing peristalsis and thus bile not being excreted fast enough and reabsorbed...

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          K 1 Reply Last reply Jan 30, 2025, 7:19 PM Reply Quote 0
                          • K
                            Kvirion @Mauritio
                            last edited by Jan 30, 2025, 7:19 PM

                            @Mauritio
                            It also worth noticing that peppermint is a κ-opioid receptor agonist...

                            https://en.wikipedia.org/wiki/Κ-opioid_receptor#Natural_agonists

                            A little learning is a dangerous thing ;
                            Drink deep, or taste not the Pierian spring :
                            There shallow draughts intoxicate the brain,
                            And drinking largely sobers us again.
                            ~Alexander Pope, An Essay on Criticism

                            M 1 Reply Last reply Jan 30, 2025, 8:57 PM Reply Quote 0
                            • M
                              Mauritio @Kvirion
                              last edited by Jan 30, 2025, 8:57 PM

                              @Kvirion said in Random, interesting studies:

                              @Mauritio
                              It also worth noticing that peppermint is a κ-opioid receptor agonist...

                              https://en.wikipedia.org/wiki/Κ-opioid_receptor#Natural_agonists

                              Uh oh..." KOR activation causes a release in prolactin,[76]"

                              But then :
                              Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro
                              https://pubmed.ncbi.nlm.nih.gov/33188562/

                              ....
                              Doesn't add up .

                              Dare to think.

                              My X:
                              x.com/Metabolicmonstr

                              A K 2 Replies Last reply Jan 30, 2025, 9:28 PM Reply Quote 0
                              • A
                                alfredoolivas @Mauritio
                                last edited by Jan 30, 2025, 9:28 PM

                                @Mauritio That might be how it inhibits LH and FSH, and is anti-androgenic, because the opioid receptor inhibits GnRH secretion when activated.

                                Steroids such as T and DHT, increase opioid receptor expression, which could be a mechanism of how they shut down the HPG axis.

                                M 1 Reply Last reply Jan 31, 2025, 4:16 PM Reply Quote 0
                                • K
                                  Kvirion @Mauritio
                                  last edited by Kvirion Jan 30, 2025, 10:40 PM Jan 30, 2025, 10:20 PM

                                  @Mauritio said in Random, interesting studies:

                                  Doesn't add up .

                                  Welcome to the real world of Complex Adaptive Systems 😬

                                  This means that reaction/influence/outcome is context-dependent. I.e. may be different for different sexes or certain conditions/circumstances...

                                  BTW Before Peatiing, I was hypothyroid with IBS-D and pretty low T...
                                  When I was using p-mint it definitely was slowing down my digestive system - in opioid-like ways.
                                  Secondly, at first, I was feeling the influence of rising dopamine (MAO-B inhibition), but after an hour or two it always turned into an increase in prolactin and a decrease in testosterone, which unfortunately was painfully noticeable for at least half of a day or night...

                                  A little learning is a dangerous thing ;
                                  Drink deep, or taste not the Pierian spring :
                                  There shallow draughts intoxicate the brain,
                                  And drinking largely sobers us again.
                                  ~Alexander Pope, An Essay on Criticism

                                  1 Reply Last reply Reply Quote 0
                                  • M
                                    Mauritio @alfredoolivas
                                    last edited by Jan 31, 2025, 4:16 PM

                                    @alfredoolivas said in Random, interesting studies:

                                    That might be how it inhibits LH and FSH, and is anti-androgenic, because the opioid receptor inhibits GnRH secretion when activated

                                    Like I said above : the study showed that peoermint increased LH and FSH

                                    @Kvirion said in Random, interesting studies:

                                    but after an hour or two it always turned into an increase in prolactin and a decrease in testosterone, which unfortunately was painfully noticeable for at least half of a day or night...

                                    Yeah too many people reports similar experience to yours, so I think it's best to stay away from it.

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    1 Reply Last reply Reply Quote 0
                                    • M
                                      Mauritio @Mauritio
                                      last edited by Mauritio Jan 31, 2025, 4:40 PM Jan 31, 2025, 4:34 PM

                                      @Mauritio said in Random, interesting studies:

                                      Dates, olives and walnuts contain the highest amounts of the phytoprogestogen syringic acid.

                                      http://phenol-explorer.eu/contents/polyphenol/420

                                      https://pubmed.ncbi.nlm.nih.gov/9704030/

                                      Not only is syringic acid a phytoprogestogens, but it also had very potent pro thyroid effects in this study.

                                      They gave rats a known anti- thyroid drug (PTU) to induce hypothyroidism.
                                      Then they gave them syringic acid or T4.

                                      Syringic acid completely restored the T3 and T4 levels of hypothyroid rats.
                                      It even increased them above baseline.

                                      T4 levels were even higher with syringic acid compared to giving them actual T4.

                                      It also lowered TSH quite drastically .

                                      @cs3000 they also included a control + synstingic acid group, and even in normal animals it helped their thyroid and increased T3 by about 30% .

                                      1000012528.png 1000012530.png 1000012532.png

                                      Syringic acid had an affinity for the thyroid receptor TRb that was twice as strong as that of T3!

                                      1000012534.png

                                      Syringic acid also increased antioxidants like SOD and catalase powerfully and lowered inflammatory cytokines.

                                      These dosages they used are not achievable by diet alone though . Maybe there is a supplement. I also read something about pomegranate peels contain syringic acid.
                                      https://pubmed.ncbi.nlm.nih.gov/34047416/

                                      Dare to think.

                                      My X:
                                      x.com/Metabolicmonstr

                                      C 1 Reply Last reply Feb 8, 2025, 6:26 PM Reply Quote 0
                                      • M
                                        Mauritio
                                        last edited by Mauritio Feb 1, 2025, 7:54 PM Jan 31, 2025, 5:01 PM

                                        Pomegranates

                                        One of the main polyphenols of pomegranate peels, Punicalagin, seems to have anti-estrogen and pro- progesterone effects. The anti- estrogen effect should be achievable by taking a supplement the pro- progesterone effect would be difficult. But this was an in vitro study in rats , so the dosages are a bit of a gamble anyway.

                                        "Punicalagin (at 100 microg.ml(-1)) significantly (P<0.05) increased progesterone secretion. On the other hand, the release of 17beta-estradiol was significantly (P<0.005) decreased by punicalagin addition (at 10 microg.ml(-1))."

                                        https://pubmed.ncbi.nlm.nih.gov/26291726/

                                        Several polyphenols of pomegranate are aromatase inhibitors.
                                        "These studies suggest that pomegranate ET-derived compounds have potential for the prevention of estrogen-responsive breast cancers."
                                        https://pmc.ncbi.nlm.nih.gov/articles/PMC2805471/

                                        "PME binds ER and down-regulated the transcription of estrogen-responsive reporter gene transfected into breast cancer cells. The expressions of selected estrogen-responsive genes were down-regulated by PME"
                                        https://pubmed.ncbi.nlm.nih.gov/21839626/

                                        This study hints at pomegranate extract containing significant amounts of syringic acid.

                                        "WPE indicated that syringic acid (SA), vanillic acid and caffeic acid were the predominant flavonoids..."
                                        https://www.sciencedirect.com/science/article/abs/pii/S0377840121000973

                                        Pomegranates peel extract increases progesterone and offspring weight and survival .

                                        "Fppee improved homeothermy, progesterone concentration, and pregnancy outcomes."
                                        "Lambs born to Fppee ewes had the highest birth weights and survivability. "
                                        https://www.sciencedirect.com/science/article/abs/pii/S030645652400261

                                        Pomegranate extract increased Energy expenditure, V02, VCO2 and increases body temp after cold exposure.
                                        Which probably means that it restores shivering cold thermogenesis, which is lost in unhealty people, meaning they can't mount an adaptive response to a stressor (cold). This is corroborated by the fact that Ucp, is increased in the Pomegranate group by 3- told, but only after cold exposure. It also increased SIRTI a lot and a protein called BMPB8, which stops preadipocytes from maturing into fully functional adipocytes.
                                        https://pmc.ncbi.nlm.nih.gov/articles/PMC9499678/#ijms-23-10460-f006

                                        Pomegranate contains 7 (!) Carbonic anhydrase inhibitors, leading to increased CO2.
                                        https://www.jstage.jst.go.jp/article/bpb1993/16/8/16_8_787/_article

                                        Pomegranate polyphenols inhbit mTOR (similar to protein restriction) . Mango too.
                                        https://pubmed.ncbi.nlm.nih.gov/27028006/

                                        Pomegranate peel polyphenols lower adrenaline and cortisol induced by chronic, mild stress. It also I I it's MAO, strongly favoring MAO-B, leading to an increase in the dopamine/serotonin ratio.
                                        https://onlinelibrary.wiley.com/doi/10.1111/pcn.12100

                                        It reduces brain lead concentrations by about 90% in animals consuming high lead amounts.
                                        https://scholar.google.com/scholar_lookup?journal=Pol. J. Nat. Sci.&title=Algerian pomegranate peel decreases lead concentration in brain and improves neurological disorders&author=L. Gadouche&author=N. Djebli&author=Z. Khayra&volume=35&publication_year=2020&pages=97-107&#d=gs_qabs&t=1738438268566&u=%23p%3DvYGsC48cmZEJ

                                        Ellagic acid (one of the major active molecules in pomegranate). Decreases brain NO and NMDA receptors.
                                        https://www.sciencedirect.com/science/article/abs/pii/S0143417919300204

                                        In this study pomegranate juice increased plasma catalase by 2x, vitamin C by 3X and and vitamin E by 5x, also increased testosterone by about 30% .
                                        https://pubmed.ncbi.nlm.nih.gov/18222572/

                                        Dare to think.

                                        My X:
                                        x.com/Metabolicmonstr

                                        1 Reply Last reply Reply Quote 0
                                        • M
                                          Mauritio
                                          last edited by Mauritio Feb 2, 2025, 4:57 PM Feb 2, 2025, 3:47 PM

                                          Vitamin A supplementation in third world countries drastically reduces mortality.

                                          "Among children aged 12-71 months at baseline, mortality in control villages (75/10 231, 7·3 per 1000) was 49% greater than in those where supplements were given (53/10 919,4·9 per 1000) (p<0·05). "

                                          https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(86)91157-8/fulltext

                                          (Mild)Vitamin A deficiency still affects almost a billion people

                                          "In 2019, VAD and mVAD affected 333.95 million (95% CI = 253.00-433.74) and 556.13 million..."
                                          https://pmc.ncbi.nlm.nih.gov/articles/PMC10416138/

                                          92% ofChildren with measles had Vitamin A deficiency. Giving them Vitamin A reduced their mortality by 50%!
                                          https://pubmed.ncbi.nlm.nih.gov/2194128/

                                          From: "Endocrine Physiology" by Constance R. Martin, Ph.D. :

                                          "Laboratory mammals maintained on Vitamin A-
                                          deficient diets stop growing, acquire numerOuS epi·
                                          the]ial cell and connective tissue disorders. and be·
                                          come blind and sterile. "

                                          "However. retinol or a precursor is needed for
                                          spermatogenesis, for the ability to sustain preg·
                                          nancy, and for the formation of visual pigments. "

                                          "Vitamin A supports bone remodeling. In defi·
                                          ciency states. the passageways for nerves and blood
                                          vessels do not enlarge sufficiently. Infants deprived
                                          of the vitamin have detective loolh formation_"

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

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