Random, interesting studies

[Mossy]

That is interesting about Chia seeds. Especially from a Peat perspective. (Or maybe I should say from my novice understanding of Peat.) Anything with seeds I've avoided since learning of Peat.

Could the powder of a Chia seed even be different from simply grinding the seeds?

[Mauritio]

@Mossy Peat even said he can't see any value whatsoever in chia seeds, which is weird because they contain a lot of polyphenols, fiber and minerals, so there is at least some nutritional value there.

And he said if someone feels better from them it's probably the laxative effect, which is more or less ruled out in the above study.

So I still dont understand how it has these effects.
And it doesnt seem to be just the grounded seeds. There's another study I posted which used chia seed extract, which was very beneficial as well.
And IIRC another one used whole chia seeds.

I think the powder and grounded seeds should be very similar. Unless the powder is somehow defattened. But suppose they would state that.

There was a thread on here recently that Omega 3s are essential and you need them for certain things. Ive only skimmed it, but maybe it has something to do with that.

So following the true method of knowledge I will order some grounded chia seeds and see for myself.

[Mossy]

@Mauritio Appreciate your thoroughness. It will be interesting to see what effect they have on you. I don't like the taste and feel of chia seeds, but maybe they could be used as a food supplement, like I do with liver.

[lobotomize]

@Mauritio 5ht1a 1b both downreg sero produc

[Mauritio]

Mauritio said:

A casual 7x increase in testosterone while it decimates prolactin. Not bad.

In the testosterone study they used 0.025g/L of chia powder in drinking water, which is an extremely low dose. This should approximately correspond to an HED of ~70mg.
Wild that even had an effect at all at that dosage.

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There's another study using the same dosing protocol also in rabbits. So HED ~ 70mg.

And it shows strongly lowered cortisol, insulin, leptin and triglycerides. With a small increase in TSH.

It also drastically lowered one protein which is part of the HSP70 family. Peat used to write about the dangers of heat shock proteins, so lowering should be a good sign.

https://www.nature.com/articles/s41598-024-82175-3#Tab5

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Many studies with Chia seeds use HEDs of 5/10/or even 50g. Often showing that the 10g or higher dose is most effective. While the lower dosage is relatively ineffective.

The above studies show that (at least in rabbits) a microdose might be all you need.
70mg/ day increased testosterone and lowered cortisol strongly.
If you want to replicate the study, measure 70mg with a mg scale and put in a big bottle of water and sip throughout the day. That is the closest thing to what they did in the studies.
So that way, you could get the benefits without overloading on PUFAs.

[jamezb46]

@Mauritio I await a report of your experience

[Mauritio]

Mauritio said:

The above studies show that (at least in rabbits) a microdose might be all you need.
70mg/ day increased testosterone and lowered cortisol strongly.
If you want to replicate the study, measure 70mg with a mg scale and put in a big bottle of water and sip throughout the day. That is the closest thing to what they did in the studies.
So that way, you could get the benefits without overloading on PUFAs.

Heres another study on chia seeds. They also use an HED of 50-70mg, although this time it is an extract.

In diabetic rats that were given low dose chia seeds extract (P3), blood sugar and MDA drastically improved. They were lower than in the control group without diabetes (P0) and lower than in the positive control group that received metformin (P1).

https://www.researchgate.net/publication/373779495_Effect_of_Chia_Seed_Extract_Salvia_Hispanica_L_On_Current_Blood_Sugar_Levels_and_MDA_Levels

A plausible explanation of the benefits could be mitohormesis. A very small mitochondrial stress could activate benefical compensatory mechanisms like Nrf2, PGC-1a or AMPK. There are studies showing Chia seeds activate AMPK.

[Mauritio]

ETIFOXINE

Has anybody tried it? It seems to be a GABAergic that strongly increases (neuro-)steroids.

Here you can see that it strongly increases Pregnenolone, Progesterone and the infamous 5aDHP in the brain, especially in higher doses. It also seems to increase andogens T + DHT in lower doses while it suppresses them in higher doses.

https://www.pismin.com/10.1016/j.psyneuen.2017.05.022

Different study similar findings:
"Exposure of frog hypothalamic explants to graded concentrations of etifoxine produced a dose-dependent increase in the biosynthesis of 17-hydroxypregnenolone, dehydroepiandrosterone, progesterone and tetrahydroprogesterone, ..."
https://pubmed.ncbi.nlm.nih.gov/25785994/

Etifoxine reverses weight gain on a HFD
https://pubmed.ncbi.nlm.nih.gov/32679124/

Etifoxine restores mitochondrial oxidative phosphorylation (in vitro)
https://pmc.ncbi.nlm.nih.gov/articles/PMC8657969/

It seems to increase GABA-A receptors or at least amplify its function.
https://pubmed.ncbi.nlm.nih.gov/10854897/

[Mauritio]

"After brushing out the effect of lifestyle factors as best as possible with statistical methods, the researchers found that during the study, participants who consumed 2 or more tablespoons of olive oil daily were 31 percent less likely to die than participants who did not consume olive oil."

https://www.ergo-log.com/this-daily-amount-of-olive-oil-may-extend-your-lifespan.html

[Mauritio]

Benzoic acid, a known uncoupler - even in small amounts - can convert to salicylic acid inside the body.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2800778/

The best source of benzoic acid are fresh cranberries.

There's also the plant Benzoe Siam which is about 20-30% benzoic acid, but not sure if theres a food grade option.

Essntial oil of plants are an inexhaustible source of interesting components, with interesting properties.

[lobotomize]

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