Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?

Mauritio

Here's another cool study for basil (O. basilicium, NOT holy basil) on Testosterone.

If anyone is still following this thread at this point you might want to go for basil not holy basil. Or both. I just haven't seen a single negative study on basil in relation to testosterone and for holy basil there are a few.

In arsenic treated rats it was able to almost completely restore their testosterone values to normal . Unfortunately they didn't have a control+ basil group , but basil almost tripled the T value of the arsenic treated rats compared to only arsenic treated rats. It also restored sperm health and testes weight and increased antioxidant enzymes drastically .

All of this especially at the highest dose of 500mg/kg, HED= 6g of O. Basilicum 95% alcohol extract.

https://www.researchgate.net/publication/356840663_Potential_ameliorative_effects_of_Ocimum_basilicum_extract_and_leaves_on_testicular_toxicity_induced_by_sodium_arsenite_in_male_rats

Mauritio

There might be a few MAO-B inhibitors in basil.
https://pubmed.ncbi.nlm.nih.gov/32883197/

cs3000

O. basilicium water extract fully restored glucose & insulin measures in diabetes model
https://scialert.net/fulltext/?doi=pjbs.2020.1010.1017
increases glucose uptake by cells

& increased sleep duration on a sedative more than diazapam , decreased time taken to fall asleep a couple minutes by itself (through GABA) so maybe best timing is PM https://pmc.ncbi.nlm.nih.gov/articles/PMC5020426/#sec162951
extract with both water & ethanol solubles had greatest effect (potential for gaba rebound though)

Mauritio

Another reason to favor O. Basilicum !
Yeah it does have a glucose lowering effect. There's a few studies on basil as a diabetes treatment . I notice the hypoglycemic effect.

Interesting in that dosage it actually caused sleep issues for me . Although that was O. Sanctum and not O. Basilicum as in this study.

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/

Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

Mauritio

"The biochemical parameters of hepatic function, renal function, glucose, triglyceride, and cholesterol level were significantly reduced in the treatment groups compared with the control group (p < 0.05)"

https://pubmed.ncbi.nlm.nih.gov/39555564/#&gid=article-figures&pid=figure-1-uid-0

cs3000

@Mauritio
looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/
Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

Hearthfire

I've grown basil the last few years, it's amazing in stir fry. I got almost addicted to it, I wonder if my body was craving the effects it was having without me consciously noticing

I know what I'm definitely growing again this year
I'll probably do italian basil and holy basil to test out both.

Mauritio

@cs3000 said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

@Mauritio
looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/
Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

Even the microdose (30mg) caused waking up to early for me. It felt like hypoglycemia, woke up with a pounding heart.

But maybe you're onto something with the GABA theory. GABA rebound is real.

I obtained dried powder of both basils and will continue experimenting.

Mauritio

@Hearthfire nice they used fresh basil in some studies so that's probably the best way to go!

wester130

could the alcohol tincture be used topically?