Urgent overdose (b1, prog)
-
This post is deleted! -
the manganese seemed to have stabilized me for the night, my blood pressure normalized (slightly lower than normal but that’s fine). But now I woke up with higher blood pressure. Feeling kinda desperate
-
@bioenergetical how did you take that much especially transdermally
-
This post is deleted! -
I don’t know if doctors will be able to help regarding this situation. Bioenergetics is a more obscure practice. Wouldn’t they put me in a more critical state?
-
Should I take more manganese?
-
I took manganese, made me feel relief. Later on, I started feeling cold and stressed. Maybe it’s because the B1 is stimulating my metabolic rate and causing other deficiencies
-
It’s still in my body, continuously burning through everything. Sometimes I am able to guess what and I feel warm and relaxed. But it only lasts for so long
-
@bioenergetical youll probably be fine in like a week
-
Good thinking on the manganese.
@bioenergetical Try magnesium and riboflavin.
Yes, good thinking there too. Mg as a cofactor. Riboflavin as a cofactor and because of the flavoenzymes displacement. More thoughts are a low amount of P5P as a cofactor and potassium chloride rather than sodium, and a lot of carbs/glucose to feed that PDH stimulated by thiamine. Which also synthesizes Acetyl-CoA for acetylcholine in the cytoplasma and therefore depletes choline. That's double-edged, too, because more choline may enable yet more acetylcholine.
Uridine 5′-triphosphate (UTP) acts as the preferred substrate for TPK1 for thiamine pyrophosphate synthesis needed as the cofactor for PDH activity. More uridine/cytidine would therefore increase thiamin clearance through the TCA but also exacerbate an already high PDH activity for even more CO2. Not sure about that, therefore.
Because of the sulphur moiety in thiamin it's also important to think of molybdenum for its clearance.
@cs3000 IME you can't "starve out" a thiamin-induced rise of carbohydrate metabolism. It's awful, keeps you nervous, "on edge" and incessantly irritable until you finally give in to e.g. cook and eat yet another pot of pasta after the previous two you've already had.
-
I feel like the B2 only works if accompanied by niacinamide. I took B6 already, not sure about taking more cause I heard that one should be more careful with that one. I was freaking out but I stabilized for a little while. Now I can tell that I’m losing homeostasis again… getting colder and more anxious. I’ll start convulsing and freaking out soon if I don’t recover whatever nutrient I need
I felt toxic after taking B2 by itself but the niaicnamide seemed to get rid of that sensation. But I’ll have to test more
-
@sushi_is_cringe
sometimes I feel that way, other times I feel like I’m done for
-
I don’t know if hospitals would be able to help me in this situation. It’s just completely unconventional
-
@bioenergetical in studies women took like 2g of TTFD with no bad effects reported which is way more bioavailable apparently than thiamine hcl. so lets say 2g ttfd orally is = 6g thiamine hcl orally so even if your transdermal actually absorbed 12g fully , you only really took 2x the highest tested dose. you probably just threw off your minerals , had a convulsion out of a combination of depleting something and your neuroticism (it’s obvious youre at least slightly neurotic based on your obsession with taking supplements) and now just gotta wait a bit for your body to normalize. id stop taking vitamins and just stay hydrated. my friend claims to actually have taken 4g of ttfd orally.
-
@sushi_is_cringe
I’m not healthy to begin with, I’m hypothyroid (anemic technically). Not sure if that has anything to do with it
-
@bioenergetical probably shouldnt take thiamine which is an iron chelator , when you are anemic. i suggest relying on food and maybe some cyproheptadine to take the edge off for the next few weeks.
-
@sushi_is_cringe
no, I didn’t mean iron deficient. I’ve had health complications to begin with. That’s why I’ve been experimenting with stuff over the past years
-
I’m at the hospital. Wasn’t sure if I was gonna collapse or anything. I don’t know if this was a good idea… they don’t seem to know about any of this
-
I don’t know if I am iron deficient currently. It’s not like I’m craving meat
-
Not sure if I’m deficient in some niche trace mineral and it’s not looking good. I’m trembling, anxious