Lobotomize-me athletic logs
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@Phoenix007 DMSO is the only carrier I use for vitamin D besides MCT oil, so I can’t really compare it to other options. I also dissolve pregnenolone and DHEA in DMSO.
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@lobotomize-me what is the ratio of DMSO to MCT oil in the solution?
Can you give your source of pregnenolone?
Have any particular benefit to report from its use? Just got my Pansterone and experimenting with it for the first time, although the doses are wuite low compared to what you would get from a pure pregnenolone supplement -
@Phoenix007 I mistyped i have mct oil as a solvent for vit d . this solution is a separate one and unrelated to dmso. i buy life it from life ext https://de.iherb.com/pr/life-extension-pregnenolone-100-mg-100-capsules/12149. benefits are hard to pinpoint
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@lobotomize-me Thank you
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I have realized betaine tmg raises acetylcholine, luckily I found it out extremely early. The only symptoms I had were inability to produce coherent sentences as fast as I normally could + reduced sentence and vocab creativity. I know this experience from accidentally overdosing for a couple of weeks b1 / cdp choline in 2 different instances. I am probably extremely sensitive to high acetylcholine
source of betaine raise acetylcholine :
https://dialnet.unirioja.es/descarga/articulo/9798868.pdf
(The main mechanism described for this effect is suggested by Waldman et al. (2023), who propose that betaine increases free choline, resulting in increased acetylcholine)https://pubmed.ncbi.nlm.nih.gov/6406829/
(Cholinesterase activity was noncompetitively inhibited by betaine ) -
This is also intresting excess acetylcholine can reduce body temperature. Specifically, studies have shown that the central administration of acetylcholine, a neurotransmitter, can induce hypothermia (lowered body temperature) in animals. This effect is dose-dependent, meaning that higher concentrations of acetylcholine lead to a greater reduction in temperature.
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@lobotomize-me said in Lobotomize-me athletic logs:
symptoms I had were inability to produce coherent sentences as fast as I normally could + reduced sentence and vocab creativity. I know this experience from accidentally overdosing for a couple of weeks b1 / cdp choline in 2 different instances. I am probably extremely sensitive to high acetylcholine
This strikes me as peculiar in the face of that the racetams improve such verbal fluency and are assumed to work by increasing ACh influx, turnover and utilization.
Also, CDP-choline has a puny amount of choline: Only 20%. I doubt you had been taking >2.5g of CDP-choline daily. Not taking into account that the choline from CDP-choline may enter the brain more effectively than other sources of choline.
Could it be a different imbalance you've been producing? The DNA and histone methylation by betaine could block all kinds of gene expressions and unbalance the other B vitamins. I count betaine and choline to the B vitamins. -
@CrumblingCookie I was taking 6 eggs a day + 500 mg cdp choline. - daily
As i was oblivious to the possible effects of acetylcholine + cdp choline has a 70 hour half life
@CrumblingCookie said in Lobotomize-me athletic logs:
The DNA and histone methylation by betaine could block all kinds of gene expressions and unbalance the other B vitamins. I count betaine and choline to the B vitamins.
I don't believe I will ever be going to be able to figure that out with extreme certainty, but it is in its current state highly improbable as I have also had similar experiences every time i took stuff which raises acetylcholine
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@lobotomize-me How do you think B1 could produce such effect? People generally experience reduced brain fog on it which would lead to better vocal fluency
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@Phoenix007 I’ve been taking close to 7 grams daily (massive amounts, honestly which probably sky rockets brain acTH levels) and I don’t even remember what kind of stupidity led me there. Looking back, it tanked my first quarter year exam scores. I made a lot of dumb mistakes, not because I didn’t know the material, but because I lacked focus and flow.
The likely culprit? Acetylcholine. High levels of it can suppress dopamine, which is essential for flow states. I’ve noticed the same pattern in my game logs: I usually play better toward the end of a match. That makes sense, since acetylcholine gradually declines during prolonged activity, letting dopamine take the lead again.
