Any experiences with DHT?
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Fluorine is the most electronegative atom in the universe. So, the effect is probably because the fluorine atom makes the molecule metabolism resistant.
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If someone wants to go full Walter White mode and attempt to add an ester, I'm all for it, but it requires a fume hood, solvents that are potentially hard to get, and some apparatus to purify the compounds at the various stages of the synthesis.
Unless someone is already involved in synthesizing drugs at home or has access to a lab, I wouldn't say this is exactly a walk in the park.
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@jamezb46 Yes, and someone who has a lab or synthesises drugs at home will probably be synthesising esterified DHT as a business - and unless he wants to synthesise DHT on his own, he will have to import bricks of DHT every month through customs... which is impossible given it's current supply and how easy it is to get caught.
The only way DHT enanthate is becoming available to the public is if someone on this "esterified DHT hype train" is rich enough to get a Chinese company to manufacture it for him, clever enough to ensure it is a pure product and to know how to homebrew it into oil vials, and stupid enough to sell steroids (very illegal)
or if the UGL labs (the main clients to the chinese steroid labs) want to start selling it - but the UGL labs aren't rich enough either - they simply heat up oils and benzyl benzoate in a beaker and throw steroids into it, and then sell it amongst 100s of other labs that sell the exact same product at the same prices. They don't exactly try to make advancements in the steroid industry or change the game. -
@alfredoolivas Right, your realism about the matter is in the same spirit as my original post was in.
I also am not fully convinced that DHTE or DHTP is even necessary given that drostanolone, proviron, and transdermal testosterone all exist.
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Subcutaneous DHT administration can provide a sustained release of unmetabolized DHT into the bloodstream over several days, offering similar benefits to esterified DHT
However, the big issue with delivering unesterified steroid subcutaneously or intramuscularly, is that they are very insoluble - typically a mix of benzyl benzoate or propylene glycol with water or oil is what the unesterified steroids are dissolved in.
The issue is that 1.) they tend to be dissolved at extremely low concentrations - 50mg per ml (I think) - 2.) they use high amounts of benzyl benzoate and propylene glycol (up to 50% v/v I think) which are toxic. This means that to administer a considerable amount of unesterifed steroid, you will need to administer a lot of toxic solvents with it. However, this isn't even the biggest issue - these unesterified steroid solutions are INFAMOUS for crashing / the unesterfied steroids precipitate out of the solution. When you inject this precipitated solution, it cannot get absorbed into the blood stream, and as a result, a cyst and swelling occurs in the injection site - it is extremely painful and if this happens during an IM injection, it causes your muscles to not work properly- if you do an injection in your quad and this happens? You can lose the ability to walk for a few days (talking from personal expereince).
However; there may be a solution - tocopherol is an excelent solvent for unesterfied steroids - I have made stable 30% progesterone solutions in tocopherol, whereas a 5% progesterone solution in benzyl benzoate wasn't stable. Therefore, the use of tocopherol in place of benzl benzoate or propylene glycol, could fix all of the issues I described above. That being said, tocopherol is very viscous - I am afraid that injecting tocopherol inside oneself, could create a depot of oil that will take too long to get absorbed - potentially forming a cyst around the injection depot. A possible solution to this, would be combining a very small amount of tocopherol with a large amount of oil that has a very low viscocity such as MCT oil - it would make a solution with a safe viscocity, that can still dissolve steroids - for example; one could have a 10% mixed tocopherol and 90% MCT oil solution - you could make maybe 2% of the solution DHT (20mg per 1ml)
If you get the viscocity issue correct, subcutaneous DHT dissolved in tocopherols and MCT, should safely deliver constant umetabolised DHT into your bloodstream for a few days. This is a cheap experiment I may plan to do over the summer.
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@jamezb46 at the low 25mg ed dose, it was in combination with 50-100mg preg ed and it took about 2 months to start seeing effect but it felt good to not have a rushed progress, felt natural.
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@alfredoolivas literally what is the point of injecting a hormone dissolved in tocopherol when oral ingestion is almost the same BA and pharmacokinetics as injections
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@sushi_is_cringe Oral administration of steroids massively reduces the half-life of steroids + their bioavailability + increases the metabolism of the steroid, so you will get less unmetabolized steroid per dose (which can be a good and bad thing - bad in this case).
Testosterone undecanoate when injected has a half-life of a month - when orally injested? The half-life is a few hours.
The bioavailability of these oral steroids is significantly reduced as well - and even when the bioavailability of oral testosterone undecanoate in combination with a fatty meal is made 120%, the half life is still a few hours!
The low bioavailability and rapid metabolism of oral hormones explain why a weekly dose of 3500 mg of testosterone undecanoate dissolved in vitamin E could be administered to patients for the treatment of Nonalcoholic Steatohepatitis without causing side effects or muscle growth. In contrast, administering this amount via injections would lead to accumulation, eventually resulting in 22 grams of testosterone undecanoate in the body at some point.
https://clinicaltrials.gov/study/NCT04134091Due to testosterone's protective effect on the liver, a clinical study was done using daily administrations of 500mg (3500mg a week) of oral testosterone undecanoate dissolved in your favourite solvent - vitamin E. Testosterone undecanoate has a half life of a month when injected - if testsosterone undecanoate's half life orally was the same as it's intramuscular half life, the testosterone undecanoate would build up to the point where there would be 22 grams of testosterone undecanoate in your blood stream.
If you had 22 grams of testosterone undecanoate in your bloodstream you would suffer extreme side effects, and look like the hulk?
Well none of that happened, because testosterone undeconate and oral steroids in general, have awful bioavailability and half life as discussed before:
Daily administration of 500mg of oral testosterone undecanoate dissolved in vitamin E was able to grow muscle mass by..... 1.9% to 2.75%
And only 10% of these patients adminstered these crazy doses of test undecanoate had side effects
There was also a fall in triglycerides and total cholesterol on average.
TLDR: As shown by a pharmacokinetics study, oral administration of testosterone and testosterone undecanoate, can bring their half lifes to a matter of hours, and give them low bioavailability. This is why patients with Nonalcoholic Steatohepatitis can take 500mg of testosterone undecanoate a day (dissolved in vitamin E) and gain no muscle and have no side effects - the latter is extremely surprising given how in bad health they are.
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@alfredoolivas whoa that study actually tests a tocopherol solution??!?!?!
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@sushi_is_cringe Yes lol. It was a clinical trial. I was amazed too
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could DHT cause Adrenal hyperandrogenism:?
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