Peaty uncoupler vs. Ozempic who wins ? New study.
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@Mauritio how has it gone?
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@Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:
It might not sound like much but 600g per week is 2,4kg a month , that's pretty decent without trying hard.
Hi, please let us know how this continued in your experience. It's been two months. Have you lost 4.8kg and gained strength?
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@Mauritio im also interested. plus did you ever try out NMN for weight loss
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I haven't continued taking it.
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@Mauritio Any particular reason why you stopped it? Or was it more a matter of curiosity and the novelty of experimenting with it wearing off?
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@CrumblingCookie I thought it increased insomnia, but I'm not sure anymore. It was also really hot when I was doing it, so taking it in the winter is probably a better idea.
I'll definitely do another round at some point. But I don't really have weight to loose, so it would be more for the other benefits.
I'd also be willing to sell a part of it to someone in Europe.
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L lobotomize referenced this topic on
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This post is deleted! -
Interesting new study on BAM15 and liver health.
"N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (BAM15) is a recently identified mitochondrial uncoupler with antitumor, anti-inflammatory, antioxidant and antiobesity properties. Although it has been shown that BAM15 has a high targeting ability to the liver, its capacity to improve liver metabolic disorders and the underlying mechanisms are not well understood. This study examined how BAM15 works in high-fat-diet (HFD) induced obese mice. Our results showed that compared with 2,4-Dinitrophenol (DNP) and carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP), BAM15 has a higher binding capacity and stronger activity in mediating proton uncoupling, and effectively promoted mitochondrial fusion, division, autophagy, and the tricarboxylic acid cycle. BAM15 improved hepatic lipid metabolism disorders by enhancing mitochondrial autophagy through activation of the 5'-AMP-activated protein kinase (AMPK) pathway. This indicates that BAM15 could be used to treat liver lipid metabolism issues and offers a solid theoretical foundation for managing lipid-related diseases."
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@Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:
BAM15 improved hepatic lipid metabolism disorders by enhancing mitochondrial autophagy through activation of the 5'-AMP-activated protein kinase (AMPK) pathway. This indicates that BAM15 could be used to treat liver lipid metabolism issues and offers a solid theoretical foundation for managing lipid-related diseases."
If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy. And of course the lipophagy, as they write. The only other drug which I know of which has been used to ease fatty liver or intracellular lipid accumulations are carbamazepine over a course of several months or hydroxy-beta-cyclodextrin per mucosal uptake (takes a looong time) or by injection. Since carbamazepine is quite some shite on the brain for many, they should look further into BAM15 for those affected by genetic lipid-accumulation defects.
It also ranks in BAM15 into the caloric restriction mimetics range of autophagy-inducers. So a shift away from carbohydrates to FAO and potentially even beneficial effects on the mechanisms of innate immunity for intracellular pathogen clearance, which by itself can greatly improve cellular functioning by ridding it of amassed (auto)phagosomes.The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation).
(A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1) -
@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.:
If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy
Good point. That might make it helpful for fighting infections.
@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.:
So a shift away from carbohydrates to FAO
People often paint uncouplers as FAO-increasers. But they increase FAO and carb oxidation.
The above article mentions it increasing TCA cycle, which can be fed by carbs and fat.
It probably also depends on which tissues we are talking about. If you want to lean out your liver increasing FAO there is probably a good thing.@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.:
The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation).
(A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1)AMPK increases SIRT1.
So BAM15 should do that, too.
