how dangerous is Metyrapone - cortisol inhibitor?
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has anyone heard about this drug?
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Why wester?
There's probably a much better option for its research/off label use.
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@ThinPicking Yep. Niacinamide in doses as low as 800mg a day has shown to lower cortisol in humans by around 20% and in vitro it acts an 11 beta HSD 1 inhibitor (stops conversion of cortisone into cortisol), enhances 11 beta HSD 2 (converts cortisol into corisone) as NAD is a cofactor for this enzyme and it acts as a GABA & Benzodiazepine agonist, so in theory it lowers AcTH, the signal for cortisol to be releeased.
Aspirin again, has shown to lower cortisol in humans in doses between 1.2 grams and 5 grams. In vivo and in vitro it signficantly lowers cortisol.
DHEA, magnesium, vitamin D3 etc lowers cortisol too, tstosterone blocks its effects etc - there is so many ways to lower cortisol, pharmaceuticals are not necessary and are likely to cause inbalances - for example, cyproheptadine, miratzapine and clonidine all nuke your cortisol and leave you tired for days.
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@ThinPicking for cushings
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@wester130 below ray cites studies that used it along with other drugs but doesn’t talk about it per se.
he mentions progesterone, pregnenolone, thyroid hormone, Aspirin, cabergoline, bromocriptine, cyproheptadine for cushings:“
Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-879029[2016]
[Possible Cushing's disease]
Ray Peat:
Has she tried progesterone or pregnenolone? I think pituitary surgery for Cushing’s has been obsolete for 30 years. Both progesterone and pregnenolone make thyroid easier to use, while lowering ACTH. Aspirin, cabergoline, bromocriptine, and cyproheptadine all lower ACTH.…
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thanks
some people also say Milk Thistle is helpful due to being a HSP90 inhibitor
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@wester130 welcome. here he mentions milk thistle:
Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-168872“
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The herbs can irritate the intestine, and I know someone whose liver function was worse while she was taking milk thistle--it's good to be cautious with them.
“I guess you could cautiously try some, if you choose to.
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IIRC anything that blocks serotonin or decreases its synthesis will have a cortisol lowering effect
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@jamezb46 ya serotonin stimulates HPTA directly, thus inducing cortisol
