Terrible Progest-E reaction. NEED to sort it out.
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Why not just use pregnenolone instead? Progesterone often does not work out for men.
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Pregnenolone doesn’t have the same benefits at doses the lion can tolerate. It feels excitatory and anti-gaba. Once the lion get up to the doses where it’s effective he runs into the same issue as with progesterone, probably due to conversion.
The lion does not concern himself with worrying about “anti androgenic” effects that other males complain about. These other males never complain of bowel paralysis, leading the lion to believe that this is a different and unrelated issue.
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@Hando-Jin pregnenolone causes the same issue once the lion is up to doses where it’s actually helpful. At low doses it’s too excitatory to be a serviceable replacement.
This isn’t an “anti androgenic” issue. When the lion sees guys complaining about response to progesterone it is almost always about it being anti-androgenic. The lion does not concern himself with these things. Never anything about gut paralysis. The lion can only assume this is a separate issue.
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@thelion Progesterone inhibits acetylcholine in the bowel.
"Both isoforms of progesterone receptors (PR), PR-A and PR-B are present in gastric smooth muscle cells suggesting a direct site of action of progesterone [35]. Preincubation of the dispersed smooth muscle cells 10 minutes before the administration of acetylcholine (Ach), inhibited the induced contraction by acetylcholine. Moreover, progesterone preincubation inhibited Ach-induced Rho kinase II activity without affecting its expression level suggesting that progesterone acts rapidly and directly of gastric smooth muscle cells to inhibit the contractile activity [34]. The same group showed that the effect of progesterone on Ach-induced contraction was achieved by the production of nitric oxide (NO] by progesterone from smooth muscle cells. Nitric oxide in turn induces the formation of cyclic guanosine monophosphate (cGMP) that activates protein kinase A (PKG) that plays a key role in smooth muscle relaxation [35].
Similarly, Colon smooth muscle contractility was increased in the inflammatory bowel syndrome model induced by water immersion and animal restraint in mice and this change was NO-dependent. Progesterone administrations reversed the increased contractility by elevating NO levels [37]."Given this, you may wish to try taking something that will up regulate acetylcholine in the intestines to balance that side effect. If it were me I would try either pantothenic acid or pantethine forms of vitamin B5 and do so somewhat away from taking the dose of progesterone (like hours?). I see that you tried B5 before so perhaps the dose was not large enough? Could try Pantethine maybe at like 600mg or higher? Otherwise there are other things that can up regulate acetylcholine like ALCAR or Alpha-GPC
Ref: https://www.sciencedirect.com/science/article/abs/pii/S2210522012000068
"Pantethine is known to increase gastrointestinal motility and improve ileal function [1]. The contractile mechanism is thought to be partially mediated by acetylcholine release from the cholinergic nerve endings [2]."As an anecdote I used to use 250mg Calcium Pantothenate for adrenal exhaustion but had to stick to using it sublingually (takes an awful long time for that tablet to dissolve lol) because of the bowel contractions it caused.
A co-factor for B5 may be Phosphatidyl Choline such that one uses up the other and may be needed for making acetylcholine endogenously.
Any headaches and I would back off of this though... excessive acetylcholine isn't much fun either.
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What @zorba990 wrote.
Possibly hand that panethine also to your relative perhaps you share common SMVT phenotypes.
@thelion said in Terrible Progest-E reaction. NEED to sort it out.:
NAFLD, and celiac disease, including a maternal relative with an intolerance to aspirin due to it causing constipation.
@zorba990 How do you feel excess acetylcholine? Swelling of mucosa and a runny nose with overall increased peripheral circulation and warmth and feeling whiny? Calcium-pantothenate dissolves really quickly btw so you could use the contents of capsules instead of solid tablets.
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I am not scientifically savvy enough to provide any other description than that I get constipation-like symptoms as well from progesterone, and the mucosa issues, but manifested in dryness of the nasal passages, not runny nose. Maybe it is intermittent — runny, then dry; but I forget exactly. It's been years since I've taken progesterone. All in all, I get what has chronically been an issue in my life — what I'd call dryness related symptoms.
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At which doses does The lion experience this? Even small doses topically? Has The lion tried any methods of inducing a bowel movement (like high dose magnesium or carrot salad) when these symptoms happen and even that doesn't work?
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@thelion Word.
Have you tried other formulations of progesterone, like Idealabs progestene or whatever it's called?
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@Mossy
In the mentioned context of Acetylcholine that overall dryness of yours could be a sign of generally low ACh levels.
If you're up for an adventure you could hypothetically seek an anesthesiologist to i.v. inject you with ACh in order to feel and observe your bodily reactions to elevated levels of it. As such a vague diagnostic approach publically doesn't really count as a valid reason I doubt anyone's up to do that "just for fun", though. -
The lion says rawr
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Nothing to add here that is earth shattering:
But
Think of progesterone as pro-gestation
With that
Constipation is very common- a big issue during pregnancy for many womenSimply lay off
You could try upping your carbs or even kcal to see if you tolerate it better
But that takes intentionality and time -
It might have to with bile acids and the gallbladder.
There is a progesterone metabolite that modulates the bile metabolism in such a way that it can cause cholestasis symptoms, constipation is one of them.
IIRC it had to with the bile acid receptor FXR.You could try increasing your fiber intake via carrots, bamboo shoots or oat bran.
You could also try adding a bit of olive oil to your diet since the fatty acids in it have a tendency to cause a stronger bile release than coconut oil.
Another option would be trying FXR agonists like bile acids, androsterone, cafestol, ... -
@CrumblingCookie
Thank you for the information. It was interesting to read of ACh being a possible factor. My first thought was to attempt to get this with food; or as @zorba990 mentions, pantothenic acid or pantethine forms of vitamin B5. But, the last 15 years has all but put me off of all supplements. I simply can't take them without adverse effects. So, for now, this ACh experiment will have to wait. Though I will make note of it.
