Chris Masterjohn: Salicylates are Toxic
-
White willow bark extract (salix alba) (Mind if not minimum 15% salicin)
Uses
Willow bark can be an effective analgesic if the salicylate content is sufficient. It has antioxidant and anti-inflammatory activity. (1)Lower back pain
Clinical data
A 4-week, double-blind, clinical trial tested 2 oral doses of willow bark extract containing salicin 120 mg or 240 mg against placebo in 191 patients. Primary outcome measure was the number of patients requiring relief medication (tramadol) 5 out of 7 days during the final week of the study. Pain index measures showed reduction in relief medication with both doses of salicin. Patients receiving the 240 mg dose had more improvement in pain index measures. Moderate efficacy was demonstrated with both doses of salicin for short-term treatment of acute episodes of chronic nonspecific lower back pain. (2) Postmarketing surveillance of a proprietary willow bark extract product reported no serious adverse reactions. (3)
Another 4-week, randomized, controlled study tested oral willow bark extract (salicin) 240 mg against rofecoxib 12.5 mg/day in 183 patients. Rofecoxib is no longer available, however both the salicin and rofecoxib group improved by 44% on pain index measures. There was no difference in efficacy between the 2 treatment groups. (4)
Sources and references:- Kahkonen MP , Hopia AI , Vuorela HJ , Rauha JP , Pihlaja K , Kujala TS , Heinonen M . Antioxidant activity of plant extracts containing phenolic compounds . J Agric Food Chem . 1999 ; 47 ( 10 ) : 3954-3962 .
- Chrubasik S , Eisenberg E , Balan E , Weinberger T , Luzzati R , Conradt C . Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study . Am J Med . 2000 ; 109 ( 1 ) : 9-14 .
- Chrubasik S , Kunzel O , Black A , Conradt C , Kerschbaumer F . Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study . Phytomedicine . 2001 ; 8 ( 4 ) : 241-251 .
- Chrubasik S , Kunzel O , Model A , Conradt C , Black A . Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain . Rheumatology . 2001 ; 40 ( 12 ) : 1388-1393 .
Interesting link (in French):
http://mirzoune-ciboulette.forumactif.org/t597-l-aspirine-est-pro-metabolique-et-anti-cancer#5031
=> Aspirin & White willow bark + Some products, where to buy. -
@Sitaruim magnesium must be balanced with calcium to maintain normal muscle function
-
@lobotomize-me That's ok, I consume dairy every day. Milk, yogurt, and cheese.
-
@Sitaruim said in Chris Masterjohn: Salicylates are Toxic:
Chris claims that salicylates block energy production in the mitochondria and can deplete glycine
LOL, that's a very reductionist approach of his, such a shame...
One cannot judge biochemical processes in isolation; our body is an interconnected and interdependent ecosystem.
Moreover, things/processes are context-dependent; for example, when Salicylates use glycine and there is not enough of it, it's bad not because of aspirin, etc., but because of poor nutrition lacking adequate glycine sources.And most probably by "block energy production," he means uncoupling. And saying that this is bad is just ignorance.
Uncoupling in the right amount, place, and time is a good thing.
As described by Haidut: https://haidut.me/?p=1680
There is also a very informative post about that on the old forum, by our friend @Mauritio https://lowtoxinforum.com/threads/uncoupling-increases-t3.40540/Chris M. still has a lot to learn...
[Edit]
Worth reading too https://haidut.me/?tag=uncouplingA little learning is a dangerous thing ;
Drink deep, or taste not the Pierian spring :
There shallow draughts intoxicate the brain,
And drinking largely sobers us again.
~Alexander Pope, An Essay on Criticism -
@Kvirion Thank you for your contribution
-
I don’t trust this guys physiognomy.
-
@GreekDemiGod Your noticing does not go unnoticed.
-
@GreekDemiGod I have learned not to discard an individual based on their physiognomy. Some absolutely outstanding humans weren't favored by the gods when it comes to looks.
-
@Sitaruim said in Chris Masterjohn: Salicylates are Toxic:
Chris claims that salicylates block energy production in the mitochondria and can deplete glycine
I won' formulate it so. The video is an interview. Not quite adapted.
Here is a developed position:
Why aspirin goes best with bicarbonate and glycine
Chris Masterjohn PhD – Video 9:42
https://www.youtube.com/watch?v=yGcOHmIFnGc
This episode is how to take aspirin safely if you have to take inflammatory drugs, to avoid / to dampen damages to the lining of the stomach.
Excerpt:
If we want to get rid of the salicylate part (Video time 3:20), we can use glycine. The amino acid glycine neutralizes salicylates. It means salicylate has no biological effect. The second thing you have to do is to pee, drink water to get it out, to evacuate residues. You don’t have to take glycine / to glycinate salicylates at first.
So to prevent the nasty effects, the faster you pee it out, the faster you get rid of possible side effects. If the pH of you urine goes from pH 6 to pH 7, you pee it out 17 times more efficiently (faster, we should say). The more you pee, the more you get rid of salicylates. (Video time +/ 4:10). If the pH of you urine goes from pH 6 to pH 8, you pee it out 25 times faster.
The second potential side effect of aspirin is that you do use glycine when you detoxify it.
CM advises 3 to 5 g of glycine for each dose of taken aspirin. (Video time +/ 6:00). CM repeats to modify pH pee up to 7 to make it easier to get rid / to recover.
Note’s editor (LucH): Begin with 2 g soda bicarbonate, taking apart from digestion when eating meat. I’d rather use potassium bicarbonate. I use one dose potassium bicarbonate (3.2 g) half an hour before bedtime when I need to correct my acid-base level. Do not stay too long at pH 8.5: Impact on Thymus. Th1 <> Th2.
I've made a transcription of the main passages of the video. I can open a new post if somewone wants it, with usual caution and staple (interaction). -
@LucH
Thank you. Very interesting about the additional benefits of white willow bark. I have both, aspirin and WWB. I will try the WWB next time. -
That would explain why aspirin doesn't help my insomnia
-
@VehmicJuryman said in Chris Masterjohn: Salicylates are Toxic:
That would explain why aspirin doesn't help my insomnia
CM advises to take take between 1 - 3 grams glycine to help get rid excess salicylates. Begin with 1 or 2 g. (2 doses of 1 g).
I'd take L-theanine 1 hour before bedtime (150-250 mg).Aspirin users are at risk of impaired folate status.
https://medicationsandnutrition.com/aspirin-folic-acid-interaction- Low inhibition of folate carrier into the brain.
Inhibition of RFC-1. The reduced folate carrier-1 (RFC-1) transports reduced folate into the brain, and its inhibition will likely result in cerebral folate deficiency. The aspirin hydrolysate salicylic acid is a likely low-affinity inhibitor of RFC-1. - Unmetabolized folic acid.
Dihydrofolate reductase enzyme (DHFR) is inhibited by salicylic acid. We can’t then assimilate folic acid. Need bioavailable folate to bypass this handicap. The active form 5-MTHF is required.
- Low inhibition of folate carrier into the brain.
