Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4)
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You take inosine WITH a xanthine oxidoreductase inhibitor such as apigenin —you raise ATP and raise your metabolic rate…there are numerous clinical trials with inosine + feboxostat but there is no need for a Big Pharma drug to do this yourself.
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@bio3nergetic said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
most likely part of trickery science: the stuff controllers and such set up to create sleight of hand
Those pesky evil scientists.
Now I think even some of these good researchers still have a ways to go to form a whole-picture idea, but researchers and studies like this are a step in the right direction.
It could be viewed as a disorder of fluid turnover. If there's an issue with exchange over the synovial membrane or those ahead of it, that could explain discrepancies in uricemia markers.
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@dapose This is a good insight into the inflammation variable as what heavy drinkers exhibit. When I used do nutritional consulting, a couple of clients had gout that cleared up with diet change, namely the pufa exposure.
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Fascinating. Have you experimented with it yourself or know of people who have dialed in the dosages?
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@jamezb46 said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
Fascinating. Have you experimented with it yourself or know of people who have dialed in the dosages?
Yes. 500mg - 1000mg twice a day of inosine. I’ve used 100mg or so of apigenin. You can also use a single drop of Eugenol instead.
Try it. It works very well. I’m doing a different experiment now, but I’ll come back to this soon.
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Thanks so much for responding. When you mention increased ATP and increased metabolic rate what kind of phenomenological effects does that manifest as? Increased temp? pulse? more sharp cognition? less fatigue? less lactic acid feeling in muscles?
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@jamezb46 yes all that. Just remarkable clarity. There are a number of clinical trials for this approach. It can probably reverse autism.
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Inosine arrives today, and I already have clove bud oil. I’m going to trial 500mg Inosine and one drop of clove bud oil, (in a gelatin cap) once a day for two weeks.
I rely predominantly on charcoal for TLR4 management, (though that comes with its own disadvantages). I’ve tried D3, Bs, antihistamines, and many of the other so called TLR4 antagonists, but nothing works for me personally like charcoal. My goal is to find something other than charcoal that I can reach for with equal effectiveness.
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@evan-hinkle incidentally, just 500mg or 1000mg of charcoal every few days makes a dramatic impact without any of the negatives of larger amounts.
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@Ecstatic_Hamster this is actually what I do now, but the day after my dose of charcoal typically slows my transit time, and for whatever reason I just can’t feel optimal without daily consistency, (I assume due to years of unchecked, and totally undiagnosed low-grade sepsis).
My hope is to be able to antagonize TLR4 while maintaining fast, complete, and regular transit. Otherwise forward progress for me tends to be a bit like sprinting on a treadmill, (I don’t move forward, just keep-up so to speak).
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@evan-hinkle said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
My hope is to be able to antagonize TLR4
Some natural TLR4 antagonist that you might consider sprinkling into your diet include:
Dried ginger is a savory source of 6-Shogaol.
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@evan-hinkle said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
@Ecstatic_Hamster this is actually what I do now, but the day after my dose of charcoal typically slows my transit time, and for whatever reason I just can’t feel optimal without daily consistency, (I assume due to years of unchecked, and totally undiagnosed low-grade sepsis).
My hope is to be able to antagonize TLR4 while maintaining fast, complete, and regular transit. Otherwise forward progress for me tends to be a bit like sprinting on a treadmill, (I don’t move forward, just keep-up so to speak).
doing the honey diet with intermittent reset days, bowel movements are loose enough and fast enough so the charcoal is absolutely beneficial to me, and not a problem at all, quite the opposite.
