Fenclonine
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@alfredoolivas hahahahahahaha oh wow
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Last one
https://kevinmd.com/2025/11/a-cautionary-tale-about-pramipexole.html
I never thought I’d be the cautionary tale.
For decades, I worked at a financial company. I’m a youth sports coach, a husband, and a father of two. I’ve spent decades coaching, mentoring players, and proudly producing high school sports telecasts. I built a life around leadership, precision, and community.
But none of that prepared me for what happened when I was prescribed pramipexole (Mirapex) to treat Parkinson’s.
The warnings were there: compulsive behaviors, gambling, and hypersexuality. I read them. I nodded. I thought, That won’t be me.
But pramipexole doesn’t come for you like a thunderstorm. It rewires you slowly. Quietly. It doesn’t feel like addiction. It feels like urgency. Like logic. Like a voice that sounds like your own, telling you this next step makes sense. Until it doesn’t.
I lost control. I made choices that devastated my family. Financial ruin. Emotional collapse. The kind of betrayal that no apology can fix. And when I finally came out of the fog (when I tapered off the drug and the compulsive pull vanished), I was left with the wreckage. The clarity came too late.
Since tapering off pramipexole, the compulsive urge is gone. It’s not dulled. It’s not managed. It’s gone. I don’t feel the same pull, the same irrational need, the same hijacking of my thoughts. That switch, the one that used to flip without warning, is silent now.
But that doesn’t undo what happened.
I sit here now knowing that I have ruined the life of my family. I realize there is nothing I can do to change what my brain did under the influence of that drug. I gambled away everything that would have made a life for my children and my wife. What I’ve done is costing me more than I ever imagined: not just the money I lost, but the tax consequences that may prevent my children from finishing college, and burden my wife for the rest of her life.
And I still have Parkinson’s. That won’t get better. I will need help, help I won’t be able to give myself. And my wife won’t be able to be everything for me or for herself. I fear what that means for her. For us.
I feel useless. Guilty. Ashamed. Like I’ve taken a step backward. But I also know this: I’m not hiding anymore. I’m telling the truth. I’m seeking help. I’m writing every day. And even if I can’t fix what’s broken, I can make sure no one else walks into this blind.
Here’s what I need you to understand: The risks and warnings won’t protect you.
You can read them. You can believe you’re immune. But pramipexole doesn’t ask for permission. It changes how your brain processes risk, reward, and impulse. And by the time you realize something’s wrong, you may already be deep in it.
This isn’t just a medical side effect. It’s a neurological hijacking. And it nearly cost me everything.
If you or someone you love is taking pramipexole (or any dopamine agonist), please don’t dismiss the risks. Monitor behavior. Ask hard questions. Don’t wait for the damage to show up before you act.
I’m not asking for forgiveness. I’m asking for awareness, for accountability, and for a system that doesn’t bury these risks in fine print. And for families to know that if something feels off, it might be more than just stress. It might be the drug.
This is my story. And I’m still living it.
RAY. PEAT. Wonder if he was laden with estrogen and PUFAs!
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The connection between dopamine and serotonin
It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa.
Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD)
Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level
Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis
SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS)
Blocking serotonin may treat obsessive-compulsive disorder (OCD)
Drop in dopamine behind giving up
And it goes on and on and on!
https://haidut.me/?s=serotonin
Looks like maybe microdosing a DA could be the way to go?
Edit: Looks like the weird side effects from DAs are truly just a stress response?
https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/
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@alfredoolivas said in Fenclonine:
Watch engineer smash all the tortas in Miami now
Speak of the devil except not in Miami
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@engineer I’m sure the taladafil came in handy
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@alfredoolivas it hasn't quite happened yet but could soon.
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selegiline is btw rlly goated it does live to the hype, better than bromantane imo
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@engineer inshallah
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If pramipexole doesn't work out, it looks like you can also increase dopamine and (hopefully) lower serotonin through MCR agonism. That would mean a peptide like melanotan 2 or PT-141. I already have some melanotan 2 but the jury is still out on melanoma risk so that means PT-141.
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Looks lik maybe MCR agonism is akin to a stress response?
Appears as though metergoline is the way to go even though it mostly works on serotonin
Now the challenge is finding bulk metergoline
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@engineer melanotan makes you black through NO stimulation btw, this is why it also gives u massive boners, prolactinogenic, not peaty, fuck melanotan all these mechanisms abt it are just speculations because "erm akshually melanin good!", didnt peter thiel like fund these popular peptides or smth idfk
MILF
man I love fasting -
@engineer metergoline is goated, any chinese nigga on echemi would sell it to you for around like 400$ a gram, 4mg a day for me gave me all the famous benefits of blocking serotonin at a significant rate, but if you can try getting ur hands on the brand name Liserdol product, its gonna be much easier
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@hwisdom it doesnt specifically touch NO, it just stimulates melanocytes through mc1r which is normally agonized by alpha msh, and NO increases mc1r expression like you would expect in a stress state
https://grok.com/share/c2hhcmQtMw_7fd6d676-eb61-41b6-8bff-c75dc29acb22
remember, iNOS is bad and eNOS is fine
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