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    Fenclonine

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    • alfredoolivasA Offline
      alfredoolivas @engineer
      last edited by

      @engineer inshallah

      engineerE 1 Reply Last reply Reply Quote 0
      • engineerE Offline
        engineer
        last edited by

        If pramipexole doesn't work out, it looks like you can also increase dopamine and (hopefully) lower serotonin through MCR agonism. That would mean a peptide like melanotan 2 or PT-141. I already have some melanotan 2 but the jury is still out on melanoma risk so that means PT-141.

        hwisdomH jamezb46J 2 Replies Last reply Reply Quote 0
        • engineerE Offline
          engineer
          last edited by

          Looks lik maybe MCR agonism is akin to a stress response?

          Appears as though metergoline is the way to go even though it mostly works on serotonin

          Now the challenge is finding bulk metergoline

          hwisdomH 1 Reply Last reply Reply Quote 0
          • hwisdomH Offline
            hwisdom @engineer
            last edited by

            @engineer melanotan makes you black through NO stimulation btw, this is why it also gives u massive boners, prolactinogenic, not peaty, fuck melanotan all these mechanisms abt it are just speculations because "erm akshually melanin good!", didnt peter thiel like fund these popular peptides or smth idfk

            MILF
            man I love fasting

            engineerE 1 Reply Last reply Reply Quote 0
            • hwisdomH Offline
              hwisdom @engineer
              last edited by

              @engineer metergoline is goated, any chinese nigga on echemi would sell it to you for around like 400$ a gram, 4mg a day for me gave me all the famous benefits of blocking serotonin at a significant rate, but if you can try getting ur hands on the brand name Liserdol product, its gonna be much easier

              MILF
              man I love fasting

              1 Reply Last reply Reply Quote 0
              • engineerE Offline
                engineer @hwisdom
                last edited by engineer

                @hwisdom it doesnt specifically touch NO, it just stimulates melanocytes through mc1r which is normally agonized by alpha msh, and NO increases mc1r expression like you would expect in a stress state

                https://grok.com/share/c2hhcmQtMw_7fd6d676-eb61-41b6-8bff-c75dc29acb22

                remember, iNOS is bad and eNOS is fine

                1 Reply Last reply Reply Quote 0
                • engineerE Offline
                  engineer @alfredoolivas
                  last edited by engineer

                  @alfredoolivas said in Fenclonine:

                  @engineer inshallah

                  I just gave mami a Ray Peat starter kit

                  20260424_145843.webp

                  alfredoolivasA hwisdomH 2 Replies Last reply Reply Quote 1
                  • alfredoolivasA Offline
                    alfredoolivas @engineer
                    last edited by

                    @engineer you don’t cheap out, I like it

                    1 Reply Last reply Reply Quote 0
                    • hwisdomH Offline
                      hwisdom @engineer
                      last edited by

                      @engineer I eat out my dogs asshole

                      MILF
                      man I love fasting

                      1 Reply Last reply Reply Quote 0
                      • jamezb46J Offline
                        jamezb46 @engineer
                        last edited by

                        @engineer Maybe you would like Bupropion for this purpose. It's easily available.

                        In time there is life but no knowledge; outside time there is knowledge but no life

                        hwisdomH 1 Reply Last reply Reply Quote 0
                        • hwisdomH Offline
                          hwisdom @jamezb46
                          last edited by

                          @jamezb46 it blocks serotonin like that???

                          MILF
                          man I love fasting

                          jamezb46J 1 Reply Last reply Reply Quote 0
                          • jamezb46J Offline
                            jamezb46 @hwisdom
                            last edited by

                            @hwisdom It doesn't block serotonin but it increases dopamine and as Georgi has written many times whenever dopamine increases serotonin tends to decrease because of enzyme competition. There are exceptions but in general the above is true as a rule.

                            In time there is life but no knowledge; outside time there is knowledge but no life

                            alfredoolivasA hwisdomH 2 Replies Last reply Reply Quote 0
                            • alfredoolivasA Offline
                              alfredoolivas @jamezb46
                              last edited by

                              This post is deleted!
                              1 Reply Last reply Reply Quote 0
                              • W Offline
                                wester130 @engineer
                                last edited by

                                @engineer extremely difficult to buy from those websites

                                engineerE 1 Reply Last reply Reply Quote 0
                                • engineerE Offline
                                  engineer @wester130
                                  last edited by engineer

                                  @wester130 what exactly is extremely difficult to buy?

                                  1 Reply Last reply Reply Quote 0
                                  • hwisdomH Offline
                                    hwisdom @jamezb46
                                    last edited by

                                    @jamezb46 said in Fenclonine:

                                    @hwisdom It doesn't block serotonin but it increases dopamine and as Georgi has written many times whenever dopamine increases serotonin tends to decrease because of enzyme competition. There are exceptions but in general the above is true as a rule.

                                    ok thought so, thought it was smth like metergoline

                                    MILF
                                    man I love fasting

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