Vitamin K2 reverses fatty liver disease
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Very interesting study in animals on vitamin K2 and fatty liver.
They induced a fatty liver in mice via a high fat diet and then added 0.6/1.2/1.8 mg (HED)of Vitamin K2 to the diet.
You can see that the vitamin K2 drastically reduced body fat gain. The most effective dose, was the medium dose (M) 1.2mg, which almost restored the body fat levels to that of the control animals.
Vitamin K2 also reversed the liver weight and the NAFLD score back to normal, indicating reversal of the pathology.
This is corroborated by the epididymal fat weight of the mice, which reflects visceral fat content, which was also strongly reduced by vitamin K2.
It is often said how visceral fat corresponds to liver fat, so this would as well hint at a decrease in liver fat to almost normal levels.
The researchers also showed that an enzyme called alanine dehydrogenase was increased by vitamin K2. They claim it's not statistically significant, but from the image it looks like an increase of about 30-40%.
This enzyme converts alanine to pyruvate and thus could help the ETC/ TCA cycle. It also seems to be able to synthesize glycine, which is very liver protective as well.
A few comments:
1.Usually the liver enzymes are elevated from a high fat diet. For some reason this was not the case, and so vitamin K did not lower them as well.2.I don't know which type of votamin K2 this was: MK7 or MK4. If it was MK7 it's quite a high dose, but for MK4 it's a low dose. I suspect it was MK7 but not sure.
3.The most effective dose was consistently the medium dose.
https://www.nature.com/articles/s41598-024-53644-6?utm_source=chatgpt.com
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1.5 mg k2 for the mouse, goodness what does that translate to 210 lb dude?
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when I eat natto my peepee smells
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@dapose that was the HED
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@Mauritio said in Vitamin K2 reverses fatty liver disease:
If it was MK7 it's quite a high dose, but for MK4 it's a low dose. I suspect it was MK7 but not sure.
It was most certainly Mk-7. The authors exclusively refer to it several times.
Also they company from where they had sourced their K2 is all about Mk-7 (Sungen Bioscience Co., Ltd). -
@CrumblingCookie ok thanks. I was hoping it was mk4 because that's what I'm using. But I think for mk4, a lot higher doses might be needed.
Back in the day haidut was talking about 20-40mgs ...Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio 100g of nato contains 850-1,000 micrograms of menaquinone 7. I think it's safe because I think people eat that much natto.
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@alfredoolivas interesting thanks for sharing. Not sure ifd like to eat natto everyday though.
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@alfredoolivas don’t forget about duck fat for k2.
Duck fat contains 3 times more vitamin K2 than ghee or egg yolks, 7 times more than butter or cream, and 13 times more than cheese or chicken liver. It ranks among the highest natural food sources of vitamin K2, second only to emu oil and goose liver pate.
Great in winter for roasting squashes and potatoes.
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@alfredoolivas natto also has nattokinase and 100g of natto on an otherwise empty stomach will get pharmacological levels of the enzyme into the blood. natto is also apparently a decent biotin and choline source.
a normal package is 40-45g and that's enough for me tbh. you can look for one with a sauce packet with decent ingredients.
the bacillus subtilis bacteria in it also produces its own antimicrobials.
it also contains spermidine.
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@dapose around 40 mgs of K2
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@risingfire As I said, the dosage i gave was already the calculated HED. So 40mgs isn't necessary, especially if it's mk7!
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Would anyone happen to know why MK7 gives me heart palpitations, but MK4 does not? I forget the exact does of MK7; it was included within a vitamin D supplement, so probably not too high.
"To desire action is to desire limitation" — G. K. Chesterton
"The true step of health and improvement is slow." — Novalis -
@Mossy said in Vitamin K2 reverses fatty liver disease:
Would anyone happen to know why MK7 gives me heart palpitations, but MK4 does not?
MK-7 is not an essential nutrient. What is essential is that you stop taking it if it gives you heart palpitations.
MK-7 has a half-life of around 70 hours. MK-4 has a half-life of around 4-6 hours. Researchers like the around-the-clock effects of the MK-7 form of K2. Adequate MK-4 is what we need in our diet.
https://minbalance.com/articles/K2-MK4-the-grass-fed-vitamin.html
A mind is like a parachute. It doesn’t work if it is not open. 👀
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@Mossy said in Vitamin K2 reverses fatty liver disease:
Would anyone happen to know why MK7 gives me heart palpitations, but MK4 does not? I forget the exact does of MK7; it was included within a vitamin D supplement, so probably not too high.
I don't know, but I get the same symptom from the MK7 form (plus headaches, even more insomnia). And we are not the only ones. It was a talking point on the raypeatforum as well and there are a few reddit threads about it.
Some guy on reddit said it was because Vitamin K depletes magnesium drastically (all the symptoms I had could be signs of magnesium deficiency). But I wonder why it's only the MK7 form that gives you, me and others problems. Maybe bcause it stays in the system way longer, like @davidps said. Perhaps MK4 would lead to the same symptons if you took it every few hours.
I've never been a big party attender, but I never went to a party where I didn't probably offend most of the people there by talking about what I was interested in. (Ray Peat)
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@Luke try having a lot of calcium and magnesium Before the vitamin K that helped me.
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@Mossy pretty sure it is sucking calcium out of blood and moving it to bone. take it with some calcium
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@Luke said in Vitamin K2 reverses fatty liver disease:
Maybe bcause it stays in the system way longer
Why the 1 mg MK4 / 1,000 IU D3 Ratio Wins
"Efficiency is not about the highest dose; it is about the saturability of the system. By combining 1 mg MK-4 with 1,000 IU D3, at the same take, supported by magnesium and Choline/Inositol, we maximize the carboxylation of bone proteins while sparing the liver's NADPH 'energy pool' and maintaining the endocrine benefits of osteocalcin."Yes, you burn Mg and you lack cofactors.
I'd still add this warning for other readers:
Avoid the "Quinone Overload"
Taking pharmacological doses (like 45 mg or even 15 mg of MK-4) when not in an emergency (fracture) forces the liver into a "detox" mode. This consumes NADPH and Glutathione, which are better used for systemic repair. 1 mg MK4 is the "sweet spot" for maintenance.
And don't tell me about the Japanese study; I know. We're not talking about bone fracture nor osteoporosis. Only homeostasis, without overload!
=> Warning when taking 400 UI Mix toco, 15 mg / 15 000 mcg MK4, 5 000 UI D3 in 2 or 3 takes / total for a day.
=> It could enhance a "weakening" of the energy pool, when repeated.
Why?
• NADPH Depletion: The reduction of quinones and the action of CYP450 enzymes require NADPH. NADPH is the "currency" used for recycling glutathione and synthesizing fatty acids. If you over-consume it to process 15 mg of MK-4, you have less "antioxidant insurance" elsewhere.
• Glucuronic Acid & ATP: Conjugating metabolites to glucuronide requires UDP-glucuronic acid, a process that consumes glucose and ATP.
• Glutathione (GSH) Risk: If the high-dose quinones undergo "one-electron reduction," they can create semiquinone radicals. Neutralizing these radicals can lead to a direct drain on your Glutathione stores. -
@DavidPS Thank you. I was not aware of the vast difference in half-life. I appreciate the detail and link.
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@Luke Interesting to know that it's fairly common; also of the possible magnesium deficiency. My doses of MK4 have been much larger than MK7, and still no palpitations. Though, I do still feel bad on MK4 — as with just about all supplements.
