Cyproheptadine (Periactin) - only sedated/relaxed/sleepier so far, are future benefits expected?
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@Maximalus I get euphoria from 2mg cyproheptadine mixed with coffee on relatively not full stomach, complete with waking dreams like in an opiate coma. it's as good or better than kratom
anyways 4-6 weeks of cypro is what I would do.
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@sunsunsun You mix it into coffee?
Tablets or liquid Cyproheptadine? Which brand?
How fast the effect kicks in after drinking it?
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Never take Cypro in the evening. It reduces Cortisol. The body needs Cortisol to wake up, being unable to do that is where the grogginess comes from. Cypro isn't sedative by itself, it just removes the barriers (stress hormones) that prevent you from sleeping.
That means you need to take it at least 16 hours (better more) before your wake up time, so most of it is cleared by the time you need to wake up and you can have your daily cortisol spike.
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What it means if I don't feel the anti-serotonin/pro-dopamine effects like less anhedonia/increased sense vividness, high pleasure response and such?
I'm taking it to cure my post-olanzapine symptoms that are basically the same as PSSD many get by SSRIs, but in my case by an antipsychotic - anhedonia (less vivid senses/pleasure response), genital numbness (no pleasure in genitals during stimulation, but normal touch sensation intact) and no effect by coffee/alcohol/etc. are the main ones
Can I expect new benefits to appear after long-term Cyproheptadine use that I don't have currently?
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@sunsunsun Can I dissolve Cyproheptadine (Periactin) tablet in coffee and it'll still absorb/activate?
ChatGPT says it's designed to be absorbed in gut and swallowing or dissolving it in a drink may not let it absorb properly
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@Maximalus no I dont mix it in coffee that would be weird
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@Maximalus Cyproheptadine works quite similary to Olanzapine. It's like the worst drug to overcome it's effects.
Olanzapine and Cypro are both serotonin, histamine, acetylcholine and dopamine antagonists.
Olanazpine:
Olanzapien:
Cypro:
Olanzapine:
Cyproheptadine:
Olanzapine:
Cypro:
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Why then many people have been cured by serotonin receptor antagonists like Cyproheptadine, Mirtazapine ?
I read that Cyproheptadine's anti-dopaminergic effects were only seen in some animal studies or something in limited conditions, but haven't been verified to be in humans
What do you recommend for fixing anhedonia, genital numbness, absence of coffee/alcohol/etc. effect, no relaxation/sleepiness by warm baths and reduced massage sensation/pleasure that have stayed now almost a year after quitting olanzapine?
What can I use that's prescriptionless or orderable online in EU?
Are there serotonin (receptor) antagonists without anti-dopaminergic activity?
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The benefits I got from periactin were from just nibbling a little bit of a 4mg tablet once a day. One little nibble a day and I felt very slightly more confident and controlled without sedation. I have experienced the sedation from periactin and it ruins my day.
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@Maximalus said in Cyproheptadine (Periactin) - only sedated/relaxed/sleepier so far, are future benefits expected?:
I read that Cyproheptadine's anti-dopaminergic effects were only seen in some animal studies or something in limited conditions, but haven't been verified to be in humans
It increases prolactin in some studies, a biomarker for dopamine
In theory, it probably can reverse the structural changes and epigenetic changes from the antipyschotics - but this takes a long time. In reality, cypro may make you very fatigued, which can make you feel helpless potentially WORSENING your symptoms.
I see you on twitter and you seem ultra obsessed into health (25+ posts a day) and are an incel. I mean this sincerely and respectfully by the way. In my boots if I were you, I would do tryptophan depletion alongside high dose gelatin or modadifinil to get the energy to improve life. Set yourself goals. I think health issues will improve over time if your life is improving. At least it did with mine. Every positive experience creates a positive feedback loop in the future, allowing you to get more. Low serotonin/high dopamine will allow you to not give up along the way.
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@alfredoolivas said in Cyproheptadine (Periactin) - only sedated/relaxed/sleepier so far, are future benefits expected?:
I see you on twitter and you seem ultra obsessed into health (25+ posts a day) and are an incel.
@maximalus since you're in Latvia, you have the opportunity to go even further and find a girl easily because there is a huge female surplus in that region. This would improve dopamine/serotonin levels even more and maybe make cypro not needed.
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@maximalus as @engineer said, you have a massive opportunity ahead of you. So many potential positive experiences that will compound after eachother. You just need the energy to get to these opportunities, and cypro isn't the way to do so. Your health will follow.
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@engineer brb going to Latvia
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The surplus comes from grannies
I think my dopamine/serotonin ratios and amounts itself aren't the issue, but rather dopamine tone/receptors are INHIBITED probably by higher serotonin/its receptor signaling
Direct dopaminergic stuff like coffee/concentric exercise/carbs/protein/light don't improve the post-olanzapine anhedonia/other symptoms even 0.1% NO CHANGE at all
So something is rewired, inhibiting brain centers related to pleasure/sense vividness
Keep in mind I only got this AFTER olanzapine
My nutrition/lifestyle was the same before
The drug changed something and it isn't going away on its own so far
