Prolactin is an innocent bystander and may even be beneficial

sunsunsun

@alfredoolivas mayhaps cortisol gets a universally bad rap as well

alfredoolivas

@sunsunsun mayhaps you expand on that?

sunsunsun

alfredoolivas

@sunsunsun yeah it probably increases metabolic efficiency, but that makes one fat & it directly breaks down muscle tissue via the elvation of le amino transferases

alfredoolivas

This study breaks it down nicely
https://academic.oup.com/endo/article/158/1/56/2751112?login=false

alfredoolivas

Prolactin mogs in glucose tolerance tests and this is observed IRL too

LunaticRed

@alfredoolivas Interesting, can you link this study?

alfredoolivas

@LunaticRed link above photo

cs3000

@alfredoolivas estrogen also helps in glucose intolerance in these models through signalling effects at the pancreas & lipogenesis lowering, so has different signalling ofc but prolactin is probably having estrogen like effects (shares some similar genes activation) (
https://pubmed.ncbi.nlm.nih.gov/12670737/
i read some connection a while back between prolactin and helping slow wave sleep though

high estrogen not good for mood & tumors but good for initial early regeneration, e.g when destroy pancreas cells with a substance or high fat, and lowers lipogenesis in some places so less to deal with on top of the high fat coming in. i guess prolactin shares some of the pathways / gene effects
https://academic.oup.com/endo/article-abstract/150/5/2109/2455831?login=false https://www.jci.org/articles/view/44564

so good in those HFD contexts & for that aspect , but when it signals high for a long time it can cause metabolic problems instead "There may be a “goldilocks zone” for serum prolactin that promotes metabolic homeostasis"

in a smaller case control study of 134 patients, the average concentration of prolactin in controls (18.38 µg/L) was found to be significantly higher than that of diabetic patients (5.39 µg/L) (109). Wang et al. also similarly showed that a high normal prolactin range (11.61-26.29 ng/mL) was most protective against insulin resistance and diabetes in a large cohort of patients with hyperprolactinemia

https://pubmed.ncbi.nlm.nih.gov/21557442/ shows high levels create metabolic problems , giving more but not high levels helped

alfredoolivas

@cs3000 I agree, the main point of this post was to warn people not to nuke it.