@Ismail Final update on this topic...

As promised above, I ran it for about another 30 days. So I did it from May 18 2024 through Aug 24 2024 which is 98 days. I then stepped down dosages over 8 days. I have continued with a daily baby aspirin (81mg) but otherwise the protocol is finished.

The benefits I noted in an earlier post remained through the end of the experiment. I don't believe I posted on this "benefit" but my alcohol tolerance was through the roof and I had no brain fog or other hangover the next day. I don't drink a lot anymore and usually limit myself to 1 or 2 drinks in a whole week; if I do 2 drinks at once I get a hangover. This protocol cured that.

Once I quit the protocol, my energy levels settled at a lower level again. My breathlessness on stair climbs also returned. My alcohol tolerance is worse than it's ever been, so other than a glass of wine once a week with my wife I don't even drink anymore. My favorite cocktails (sidecar, manhattan, gin martini) now make me feel terrible after just 1 of them.

I wish I had better news. At minimum, I'll say this protocol was safe for me but I see little reason to try it again any time soon.

@cremes It has now been another 30 days. I've remained on the protocol and feel mostly fine. Temperatures are still good. Weight is unchanged. Body comp is unchanged.

I've been seeking and getting ~7k IU of midday sun per day so I'm getting a nice tan. I have not noticed better sleep, weight loss, or other benefits. I assume my vit D status is low and I am now rebuilding it. I'll likely take a vitD blood test soon so I know where I'm at.

For a while there I thought maybe this protocol was improving some skin tags I have near my left and right armpits. However, while one or two tags "died off" the others are unchanged. I also had a mole on my right quad which has shrunken to almost nothing in the past 2 months. I am unsure if this is due to the protocol or due to the sun exposure.

I'm going to go another 30 days for a full 90 and then re-evaluate. I'm almost certain to take a break at that point. I imagine I should wean myself down over the course of 3-5 days instead of quitting everything cold turkey.

Sorry I don't have stronger benefits to report. I am unhappy about that too.

It's been a tad over 2 weeks since I started the protocol. I weight about 100kg so the math is really easy. I take 3 grams niacinamide, 1.5g thiamin Hcl, 1.5g aspirin, and 300mg biotin/b7 each morning. The aspirin is crushed into my morning Earl Grey tea along with 2 tbsp of honey. I eat the pills with water while the tea is steeping and then drink the tea over the course of about 20 minutes.

A few observations...

• I feel better
  As a heart attack survivor of ~2 years, the first 18 months of it I had to get used to being out of breath from climbing stairs to the second story of my house. This annoyed me but I was acclimating. Since starting the protocol, my breathlessness has eased significantly.

• Warmth
  I already take ~20mg of kuinone/K2 and 3x 2 drops of Tyromix each day. My temperatures were improving but were still sub-98F. Since starting the protocol, my waking temp is 98.4F routinely and during the day as I eat my ~300g of carbs I am measuring 99.4F at times.

I have not noticed any weight loss or body recomposition.

Will continue for at least 2 more weeks and then I'll decide if I will extend for another 30 days.

@Norwegian-Mugabe said in PUFA can cause male infertility by inhibiting oxidative metabolism (OXPHOS):

People will let other men impregnate their wife before fixing their diets.

Wow, where did this come from? I had to reread the original post twice. Nope, this comment is a complete nonsequitur.

On twitter, @haidut mentioned using vitamin K3 as a safer version of DNP to drop some weight. (This was back around ~Mar 15 2023.)

In one of the reply streams, someone posted a link to this product:

https://www.medixlife.com/shop/vicasol-buy-online-menadione/

I am not aware of a US source. I would love to find one and give it a try.

@cremes said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

@evan-hinkle said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

BTW, I'm serious about the latter part. As bioenergeticists, we believe that most/all diseases are brought about by broken or sub-optimal metabolism. If it's true, then this protocol should also serve to potentially solve type2 diabetes, heart disease, hypertension, IBS, dementia, alzheimers, OBESITY, and autoimmune diseases like MLS, Lupus, etc.

I have heart disease. I'm going to try this protocol and see what happens. I'm already taking B1, low-dose B3, and aspirin daily. I just need to adjust the amounts a bit and add in some biotin.

This morning I have started this protocol. If this helps restore my oxidative phosphorylation to youthful levels then not only does this cure cancer but it should broadly cure other metabolic diseases.

30 days starts now. I will re-evaluate ~June 15 assuming I don't run into an issue that forces me to abandon this early.

@evan-hinkle said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

https://www.sigmaaldrich.com/US/en/product/aldrich/d109606

Between this and some vitamin K3 we could lose weight and cure our metabolic diseases at the same time.

BTW, I'm serious about the latter part. As bioenergeticists, we believe that most/all diseases are brought about by broken or sub-optimal metabolism. If it's true, then this protocol should also serve to potentially solve type2 diabetes, heart disease, hypertension, IBS, dementia, alzheimers, OBESITY, and autoimmune diseases like MLS, Lupus, etc.

I have heart disease. I'm going to try this protocol and see what happens. I'm already taking B1, low-dose B3, and aspirin daily. I just need to adjust the amounts a bit and add in some biotin.

@evan-hinkle said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

@cremes just as an update, I still have my thyroid nodule. I was taking the combination in the morning after breakfast and I don’t think I was well fed enough for the powerful combination. I switched to after lunch and am tolerating it much better. That said, seemingly no change in my nodule, som somewhat bummed, but am willing to continue with the protocol at lunch where I have a better base on food on board.

Thanks for the update, I appreciate the details.

@evan-hinkle You wrote:

I'll be 3 months in at the end of April.

I wonder when we can say "we are cured" when following this kind of supplement plan. I wouldn't want to do this forever. Is 30 days enough? How about Evan's 90 days?

There has to be an end to it otherwise it's no cure at all.

@evan-hinkle I'm interested in dipping my toes into the K3 waters. Any idea where some may be procured in the US?