Posts made by albion

My protocol to minimize agaritine:

1. Crush roughly with hands
2. Boil for 1 hr in uncovered pot, dash of vinegar to lower pH (uncovered + lower pH will dramatically decrease agaritine)
3. Salt, coconut oil (a lot), maybe more vinegar to taste
4. Immersion blender until fine but still shows "pulp" or "mince" texture—when blended to "juice", I find the cognitive clearing effect is greatly reduced
5. Put lid on, boil for extra 1-2 hrs

Are there ANY possible issues with high-dose pregnenolone (~100mg/day)? Could it "overload" the liver in any way? Would vitamin A dose have to decrease to compensate for reduced need to convert T3?

Most studies use this amount or more... interested to try. Welcoming any personal anecdotes, cautionary tales.

The art hoes who are "peating" because it's cool and BAP mentioned it. Grinds my gears. Popularized by red scare pod. Completely performative

Thiamine increases uptake of zinc and reduces hemolysis due to deficiency: https://pubmed.ncbi.nlm.nih.gov/15235145/. So maybe thiamin-deficient could also have functional vitamin A deficiency via zinc. Maybe Charlie felt VA-toxic due to thiamin deficiency.

@brad Thanks Brad

When I click a category, the default sort order should intuitively be "Newest to Oldest" instead of the current "Oldest to Newest." I'm on mobile so not sure if replicable.

Edit I'm retarded, u can change in settings

@SneedyPeat micronutrient deficiency is a risk

Update: After doing a range of doses from 300-1000mg (split into 2) for one week and feeling little to no effect, I took a single large 1500mg dose and the Effects were profound.

I've been peating for nearly 2 yrs now. Started off great, got even better, then hit a horrible phase of fatigue and anhedonia. I think maybe the increased sugar depleted my thiamine. Even had weird neuropathy symptoms at some points. Hopefully this works, I'll keep updating this thread for any future observers.

P.S. The reason I took this large dose is due to Costantini et al. (2013) who had some "non-responder" participants who didn't budge until 1500-1800mg/day (free PMC: https://pubmed.ncbi.nlm.nih.gov/23696141/). "Patient numbers 2 and 3 never reported any improvement until the dose was increased up to 1500 mg/day, orally. An abrupt improvement instead occurred at doses of 1800 mg/day." The paper doesn't detail whether this was a split dose or not.

@Fructose @Dulkadir There is also a discussion regarding "saturating" the active processes with thiamine such that they upregulate their constituents. I'm really not sure why saturating an enzyme would cause upregulation instead of downregulation, but many of the seminal papers by Constantini and Lonsdale discuss this... i.e., there is an effect beyond simple "absorption" or "deficiency"—a biochemical shift of sorts; like tipping the ball over the homeostatic valley.

Anyone done this long-term? I've read the good studies and checked out Elliot Overton but I'm curious to hear a Peater's experience.

I'm about to start taking 1500mg/day Thiamine HCl.

@bunchwidth Infrared is shown to have a U-shaped relationship with cellular health, so spending all day in infrared or even red light is likely unwise. Especially considering the heating effects of infrared on the cell.