@risingfire He only said that recently if I'm not mistaken.

@Isaac Because he was a pioneer, and never claimed to be 100% right about everything or to hold definitive answers and truths in biology. He still lived older than average, in good health, while having suffered heavy health issues when he was younger which is a good indicator that he was in the right direction for a lot of things. It's now our responsability to take his work one step further.

Seems Garett Smith has anger issues, probably from his lack of neurosteroids: https://x.com/MikeFaveScience/status/1769961846037954747?s=20

Reminds me of Walter Sobchak in The Great Lebowski.

@_K How many calories do you eat per day, what's your weight, height and age? I used to suffer from similar problems when I wasn't eating enough calories.

@GreekDemiGod said in Why are Statins bad if your cholesterol puts you in the range of CVD risk:

@Creuset You want to reduce the risk in normal population, who is not mindful of PUFA intake and will never be. People need to be given solutions that work without changing their nutrition or lifestyle much.

I personally don't want anything no, I am not a moralist nor a politician, and I don't consider other humans as cattle that need to be led by a shepherd. I am just trying to describe what we know about a specific topic and to be accurate about it (and I don't claim to hold the absolute truth on a topic, always open to new evidence).

Besides, if the current medical recommendations were actually working to reduce risk of CVD, we would see a reduction, yet we actually see the opposite.

I just got out of the ICU, I'm still in the hospital and getting lots of blood thinners and anti coagulants, honestly, I'm very scared of the future, when I get home or start to work again, bit is not the reason I came here.

I have 1m 70cm, 86kg, strong build but definitely have a dad belly. Since I was a kid I have a very high cholesterol, when it was discovered (10 years old) it was about 800, and I was not a normal kid, my case was even used in a conference to show that body fat is not exactly equal to low cholesterol.

I have a history of heart disease in my father's side, my grandpa had a heart attack at 52 and my father had a defective valve on the aorta, he died in the surgery about 15 years ago.
https://www.reddit.com/r/keto/comments/16eocc8/im_27_and_just_had_a_heart_attack/

This is anecdotal evidence. I already posted this earlier, how do you explain it:

There are people that are genetically predisposed to have high LDL and high cholesterol levels, yet they don't get a higher rate of cardiovascular diseases than people with normal cholesterol levels: https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391

@GreekDemiGod What is your evidence for this statement?

Also, do they only have hypercholesterolemia, or also high oxLDL, triglyclerides, obesity, hypothyroidism, and other metabolic problems?

And how many PUFA are they consumming?

I see many possible confounding variables if you only analyze things from this single angle.

@peatyourmeat Probably because coffee is anti-opioid: https://pubmed.ncbi.nlm.nih.gov/15088081/

Travis on the previous RPF used to talk about this kind of things.

@insufferable said in Metabolism: sloth to a dopaminergic child:

I agree that internet distraction is bad but I've done long days on my LCD working with text only (almost all black and white) with very little distracting internet browsing, and still felt super drained at the end. But on my E-Ink device, I can even watch videos and click around, and still feel very good at the end of the day.

Have you ever tried used an app like f.lux to reduce the blue light emitted by your screen? Would be interested to know if you would feel the same as when using your E-ink screen.

@Nabokov said in Why are Statins bad if your cholesterol puts you in the range of CVD risk:

Ray wrote about the false link between cholesterol and heart disease, but I just came across this study which conclusively links pravastatin to a lowered cardiovascular rate and the data and design look sound. https://pubmed.ncbi.nlm.nih.gov/26864092/

There are many studies on the apparent efficacy of statins, this one isn't particularly special, but it does seem to prove that they work, which Ray disputed. Does anyone have a better understanding of cholesterol, CVD, and statins?

The main problem is oxidized cholesterol, particularly oxLDL (oxidized by PUFA or other oxidative and inflammatory things).

There are people that are genetically predisposed to have high LDL and high cholesterol, yet they don't get a higher rate of cardiovascular diseases: https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391

Some studies show that statins can be anti-inflammatory and anti-microbial aside from their anti-cholesterol effect, so this might be why some studies find that it lowers CVD:

https://www.nature.com/articles/nrd1901
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447369/

@yerrag said in New "Mission" of RPF:

@Creuset said in New "Mission" of RPF:

@yerrag said in New "Mission" of RPF:

@Creuset

Are you saying this because you trust everyone and you leave your house doors and car doors unlocked? Either you live in the boondocks or you are too smart for your own good.

You seem to be assuming too many stuff and on defense mode man, relax, I was not talking about you but about Tara.

I will make it clearer since you didn't understand: Tara used to be a wise member, but when the covid craze hit, she got into full paranoia mode, probably because she is a nurse and everybody around her got afraid. Fear can be very contagious, and make smart people act stupid, especially for women who are usually more easily scared than men. I still remember perfectly when this pandemic hit, everyone around me was freaking out and completely irrational, so I'm not surprised at all that she would act this way.

Not saying that your hypothesis about her or Charlie are necessarily wrong by the way, even though I don't think the likelihood of this happening is high.

Sorry for taking your words out of context. I couldn't see thru the forest here, thanks for clarifying. You make a good point about Tara. Being in the trenches would be traumatic, and her perception could have been affected greatly.

It's still hard to think she could be so rattled. My impression of here was that of someone who has a moderating demeanor, and not one to easily be influenced by noise around her. She was nice to be around, like a fixture at RPF.

No offense taken, thank you for your respectful reply.

I know what you mean about Tara, I was also very surprised by how she reacted. However I've observed intelligent and wise people snap under specific circumstances already, so wouldn't be surprised if that's what happened to her.