Not sure if I will get any more tips in this thread but I wanted to add some information for anyone still reading. I measured some other metrics like HRV which was very high at 100+ most days, reaching over 130, indicating parasympathetic activity (good). I also measured deep sleep and I am getting over 2 hours each night, and over 2 hours REM also. I do not think dreaming indicates anything bad, otherwise my deep sleep would not be so high.

I also thought about the whole stress driven metabolism thing which seems unlikely considering these things and other bloods and I can almost guarantee that I am not too lean.

If anyone still has any advice I would appreciate it. I have experimented with the things in this thread and more but has not changed my situation one bit. My state now is even worse than when I wrote the post.

Edit: I want to thank the people that left some ideas, it is really appreciated!

@onliest No health conditions. TSH 1.1 last time I checked, time before that I think it was 0.8 with T3 at 4pg/mL which leads me to believe that thyroid is not an issue. I get enough sunlight during the summer at least, during winter it is trickier where I live but I guess that aligns with my biological needs.

I probably do not live a very meaningful life right now, that is largely because of my mental state though. I do socialise a lot and spend time outdoors, etc - which I guess is meaningful.

I have done CBT and worked with psychologists. The last one literally told me that she could probably not help me. I have tried all of the mainstream stuff and it does not work for me.

My bloodwork is good, stress seemingly low, I do various things like carrot salad etc to lower estrogen, proper circadian rhythm... It seems the issue is not any of these things. I know neurotransmitters are somewhat unrelated to other markers and more tricky to influence. Though phenibut (strong gaba agonist) does barely nothing for me. I am afraid I might need something that works more quickly right now.

@onliest I have tried it with no effect.

Some supplements I have tried:
Pregnenolone
Progest-E
TUDCA / other liver supplements
NAC
Glycine
Taurine
Bitters
Zinc
Magnesium (topical & oral)
B-Complex (& methylated)
Phenibut
Doxycycline
Methylene blue
Gelatin
Aspirin
DLPA phenylalanine
NBMI / Emeramide
and more...

(Most if not all of these have been from reputable sources)

I have literally not experienced a single positive effect from a single one of these (except mild benefits from phenibut). Sometimes they had negative effects but 90% of the time they did nothing. I have tried a lot of these with high/low dosages etc, following recommendations from others.

I have good bloodwork and other markers btw.

@Iamnobody Thanks! I will check this video out.

Are there any viable antidepressants? I am aware it is not healthy long-term but I need something. I was thinking about stuff like DNRI (wellbutrin) or maybe even psychedelics.

@LucH I have translated the blog post and will run this candida protocol with caprylic acid included. Thanks for the info!

@Kilgore I’ve heard some people say that, but others have a completely different opinion, which confuses me. I’m not sure it’s that big of a deal, though. I used to not remember my dreams much, but I wanted to learn about lucid dreaming, so I started keeping a dream journal. Ever since then, I’ve remembered my dreams quite well, and I believe most people could do the same. I’ve noticed that taking glycine before bed helps me dream a little more though. My main point here is that I might not dream more than anyone else, but I do remember them because I learned how.

@Peatful Yes, I do have a vision, and as far back as I can remember, I have always been very ambitious—and I still am. I do not smoke weed and never have. I also haven't tried any other drugs except for phenibut and alcohol, and I’ve never used nicotine either.

@Peatful I will get back to you with the exact temps you asked for. The range I gave you is what I remember measuring before but I do not measure often at all. I will collect some data that may help find the root cause. To be continued...

@LucH
Very interesting insights! I will for sure do the candida test. What is a proper treatment for candida in your opinion? Would caprylic acid work?

Regarding the other GI issues:

• Smell is generally not too bad, but sometimes it is especially on tudca when experiencing "bile dumps".
• I have up to 4 bowel movements per day and average I would say is a bit more than 2. The consistency has improved.
• On the bristol stool chart it is usually between 3-4 but rarely 5-6 as well. During the 5-6 days I seem to have less bowel movements in total.
• I would guess fermentation is in the stomach as I generally have the bloating issues quickly after eating.

I generally eat very little histamine and oxalate rich foods but I could try to lower it further.

A lot of this stuff I have overlooked and know only very little about. What would you recommend as treatment for these kinds of issues?

Thanks!