@yerrag said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:

@Insomniac

I've long considered the benefit or harm from mere increasing or lowering of bp to be dependent on context. People in relative good health worry about rising BP, only to realize they haven't yet experienced the other side of the coin in poor health, where low BP is what needs to be concerned about.

MB causing high BP is more s function of MB increasing metabolism, and when that happens, there isn't much to be concerned about.

Good points but the heart enlarges to compensate for the higher pressure. Wouldn't increasing pressure cause the heart to continue to deform?

https://www.heart.org/en/health-topics/high-blood-pressure/health-threats-from-high-blood-pressure/how-high-blood-pressure-can-lead-to-heart-failure

High blood pressure adds to your heart’s workload: When arteries become narrow and less flexible, it’s harder for blood to travel throughout your body. This causes your heart to work harder.
Over time, a higher workload leads to an enlarged heart: To deal with increased demands, the heart muscle thickens and becomes larger. The heart can still pump blood, but it becomes less efficient. The larger the heart becomes, the harder it works to meet your body's demands for oxygen and nutrients.

Some scary animation:
https://watchlearnlive.heart.org/index.php?moduleSelect=hrtflr

@yerrag I hope you're feeling well.

Methylene blue will raise your blood pressure. It might be dangerous for someone with heart failure and an enlarged heart.

@smok There isn't much I can add but if I had (or might have) a fatty liver then I would eat choline and maybe other methyl donors. Choline can help export fat from the liver.

https://www.nature.com/articles/s41586-024-08165-7

In summary, it remains unresolved whether individual cells retain a metabolic memory and whether it is conferred through epigenetic mechanisms. Here, we set out to address this by first performing single-nucleus RNA sequencing (snRNA-seq) of AT from individuals living with obesity before and after significant WL, as well as lean, obese and formerly obese mice, confirming the presence of retained transcriptional changes, and, second, by characterizing the epigenome of mouse adipocytes, which revealed the long-term persistence of an epigenetic obesogenic memory.

One of several publication images:

@Insomniac said in Is a slowing pulse and lowered body temperature while dieting a problem?:

what-about-bob

Great film

@what-about-bob said in Is a slowing pulse and lowered body temperature while dieting a problem?:

what is ideal weight. ?

The weight which creates the best metabolic profile without biohacking.

@GreekDemiGod said in Is a slowing pulse and lowered body temperature while dieting a problem?:

Pulse in the 50s is quite low.

I agree.

@LucH said in Is a slowing pulse and lowered body temperature while dieting a problem?:

Note: I can give a link to my log if desired.

of course.

@LucH I automatically track calories and for the most part remember everything I eat. I pull back on sugar because it stimulates my appetite.

Do you feel the lowered temperatures etc is more harmful than the benefits of being at an ideal weight?

Note: If you slow too much your metabolism, you won't be able to recover a stable weight.

I'm hoping exercise will prevent any permanent metabolic damage. It's a risk from my reading

I could maintain a higher temperature if I lose the weight slower but then I need to diet for longer and I want to stop dieting and eat a normal amount.

My morning temps are in the 96s and pulse is in the 50s as I'm approaching my ideal weight.

I was phobic about a pulse under 75 and temps under 97.8 but this sabotaged my weight loss efforts. I've decided to ignore the issue this time around but I"m still tracking it.

@ThinPicking

Good point. Safety hammers and oxygen alarms the new must have accessories for "smart" vehicles.

But that would let you change your mind.

Eh tu, Elon?

I think we can all see where this is headed. DeathX
Tesla's 'Model 2' Is Expected to Be a Compact Version of the Model Y

I'm sure the the death button will only be a factory option.

https://www.youtube.com/watch?v=LwlokQCDR8Q

https://gizmodo.com/controversial-assisted-suicide-pod-cleared-for-use-in-s-1848167349

Controversial Assisted Suicide Pod Cleared for Use in Switzerland

The unit helps a patient painlessly end their life by flooding the chamber with nitrogen.

Assisted suicide booths, a longtime fixture of sci-fi, may soon be a thing in Switzerland. Swiss outlets report that the manufacturer of a 3D-printed assisted suicide pod called the Sarco capsule has received legal approval to be used by the public.

How more people will end up killing themselves by accident:
https://www.youtube.com/watch?v=WYateGAgZKY

@CrumblingCookie said in Medical Assistance In Dying. MAID:

That said, to those who find themselves at the irreversible end of such willful malice,
or to those who find themselves at the end of otherwise greatly unfortunate fates...

This narrative is very useful for framing support for widespread euthanasia as loving and compassionate.