Posts made by SpaceManJim

@Serotoninskeptic Can you expand on that?

People from the old RP Forum take all kinds of supplements (check out Haidut's store for instance). Why would a multivitamin be worse than taking XYZ other supplement?

For convenience and to get away from swallowing 10+ pills everyday which may or may not be necessary... I'm wondering about multivitamins.

Are they useful to support good health and give nutrients from a Peat-inspired perspective?

I've seen long-term studies (observation I guess, so grain of salt) saying no benefits.

One positive factor is that they seem to have a lot of things in lower doses, something Peat generally endorsed. For example, I read he'd only recommend in the 10s of milligrams of B vitamins (i.e. not these crazy B50 or B100 formulations), and up to 2K IU vitamin D (multis tend to have 400-800 IU from what I'm seeing, so a decent supplement to some somelight).

What say you, any multivitamin takers here? Recommended brands? Fillers/additives/ingredients to watch out for?

Seems like a great supplement: anti-estrogen, anti-prolactin, helps counteract PUFA to some degree, seems to feel pretty decent for me lately. However, higher doses I noticed can cause some extra bleeding, e.g. from a small scratch, brushing gums a bit hard, etc.

So how about something like 100 iu daily, would that be safe? Mostly I'm interested in the anti-PUFA effects, because it's hard to avoid dietary PUFA especially if you eat out a couple of times per week.

Thoughts on vitamin E safety?

Interesting that no one has specifically called out (just) D3 yet. I recall it being a top supp by people like Haidut and Danny Roddy (please correct me if I'm wrong).

Vitamin E is fantastic too but I don't know about daily - I think it's great on a day where you eat out some not-so-great food that may have PUFA, and/or maybe as a weekly therapy.

@b1 Interesting, that's a pretty low dose. I hear ppl talk about 1-15 milligrams (mg), which can be expensive or hard to get.

I switched recently to trying a D3+Mk7 hybrid but I think I prefer Mk4 as well. I hope Mk7 doesnt do anything funny to the heart...

@b1 Do you have any preference on the type of K2, i.e. Mk4, Mk7? What amount?

I'm wondering what people value as their most important daily supplement (vitamin, mineral, hormone, etc). For your choice, why?

(Focusing on something you'd want to take daily, not something you might take acutely based on a short-term issue).

@LucH Hi there thanks for the comprehensive response! I am still working to digest this. Two quick questions in the meantime -

I actually have a full genetics panel, what genes/mutations should I look for, and at what values, to determine if I have some methylation issues?

And secondly, do you have any further practical recommendations regarding my supplement usage? I agree with most others that "less is more" and I will be experimenting to see if I can do well with lower doses of B6.

Btw, prolactin is probably an issue for sure, I had minor childhood gyno, maybe even still a little bit now as an adult though much less so. I notice that I feel flabby on bloated in the torso region specifically after sexual activity, but reliably I can pop a B6 afterwards and reverse it.

@Loulou thanks for your comment. One consideration is the type of B6 - my understanding from reading the old RP forum is that P5P - not the form I take - is absorbed about 10x more than pyrodoxine HCL, so it's possible if he's referring the P5P at 10mg, that there is some equivalence to my 100mg.

Background: early 30s male, physically active (weightlifting), fairly athletic build. Main issues experienced periodically have to do with general fatigue and malaise, bloating, puffiness (face, torso), and related to that would be water retention.

Now I've experimented with pretty much all over-the-counter and RP-discussed supplements over the years, many of them I've purposely tried on their own 1 day at a time, to really see if I can feel and notice the effects.

But I gotta say, nothing does the trick like vitamin B6. In particular, I take 100mg pyrodixine HCL (the generic/cheap version). It literally fixes any and all issues that I get. For example, if I take it before a workout, there's very little fatigue during and afterwards. The big one for me is water retention and bloating - B6 consistently reduces these symptoms unlike anything else I've tried.

OH - it also lowers my blood pressure consistently. On any day where I am overworked from the gym or general life stress, I can pop a few 100mg's and go from 135ish back down to near perfect 120/80. Finally, B6 also just gives me more energy to engage with the world; to take on projects that I'd previously shelved, communicate more with others when I'm feeling more introverted, etc.

I'm at a point where I've stopped taking any other supplements recently because it seems any and all benefits I'm getting are from B6. Maybe a multi to round out some other bases. But I've tried so many other things, all the fat solubles, zinc and magnesium, high dose B1, B3, etc. Interestingly when I take other stuff, I get less of B6's benefits.

My questions are:

• What exactly is B6 doing for someone like me? It consistently reduces stress and "puffiness", seriously I can look like 2 different people a few hours apart (water retention I'm guessing).

• Is it safe to take 100mg+ pyrodoxine HCL a day, sometimes more?

• What kind of things can interfere with B6's positive actions for me? I've tried the "kitchen sink" approach of taking all the good "Peat inspired" supplements I've read about over the years: fat solubles, niacinamide, certain minerals, etc, but have noticed neutral to negative effects with them.

Interested in any other discussion to do with B6 as well, positive or negative. What has been the experience for others?

Cheers