Topics created by SpaceManJim

@Kvirion no the joke being people will hear what they want to hear. you were clear

*) In Short
RDA: 0.8 g
Sweet spot: 1.2 – 1.6 g
To build muscles: 1.6 – 2.4 g
Source myprotein.com
Note 1: Masterjohn advices to mind B5, B6 B8 (biotin) + molybdenum (but mind excess) on high protein diet. => Youtube: The Three Nutrients You Need More of on a High-Protein Diet + masterjohn.
Note 2: HDP (PLP) 1.58 mg of B6 per 100 grams of protein per day.
Note 3: We should balance methionine with glycine.

could probably take more D and A than what you've listed. move the vitamin E to Saturday Sunday only and take the K tues-wed-thurs at 5-10mg (with 35g fat for max absorption) so there's less risk of the K oxidizing the E

@Jennifer
Wow, that is potent oregano; and now that you mention it, it is actually Greek oregano that I'm using in my oregano extract. I didn't purposely seek out Greek, but in my research it seemed to be quality. I definitely don't mind oregano in food, and actually like dishes that have it in it. Your using it as a tea is a good idea, when using it as a supplement.

Very interesting about belladonna. I've never heard of that before, but will keep it in my notes for gall bladder issues. You've had to overcome a lot, but it's made you knowledgeable in the process.

@BioEclectic said in Does anyone take a multivitamin? What to look for in it?:

interesting note about the B50 complex. I recall you mentioning before but i don't recall the backup detail (?) That potentially harmful?

AMPK sensor: Friend or foe?
@BioEclectic
Starting point: Too much of a good thing can become counterproductive (cancer).
BioEclectic, a forum user on bioenergetic.com, recently asked me why it was not appropriate to regularly take a complex Vitamin B50 supplement. OK if it's 2x/week or these are the RDA if taken regularly, knowing that we will then have chosen a co-enzymated form (with cofactors), without yuck ingredients. (…)
Short answer:
AMPK functions as an energy sensor in our cells. This sensor plays a key role in the balance between anabolic and catabolic programs for cellular homeostasis in response to metabolic stress.
In the case of a tumor, the cancer cell attempts to slow down oxidative metabolism and works to divert the supply of glucose for its own benefit in order to grow. The cancer cell will therefore try to down-regulate the influence of AMPK, which acts a little too much like a traffic agent to supply the different organs, instead of promoting the flow of fuel to the advantage of his own needs.
So, what the link with cancer?
Taking high dose of thiamin (B1) or pyridoxine PLP (B6) – they are just 2 examples of antioxidant – they act to moderate the AMPK sensor, to dampen the effects. Right in cure or if the dose turns round RDA but not for prolonged use.
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems.
Cancer cells try to moderate / neutralize anti-stress.

Full answer on my forum, with link in English and in French (translator needed).

Cancer cells are usual, at a certain age, and have to be considered “normal” if the size does not exceed a €2 coin… AMPK as a regulator of energy metabolism How much B vitamins do we need, in which proportions? How can we modulate the sensitivity of the regulation? Cancer cells divert the supply of fuel and try to avoid oxidative stress. What’s the link between B1 and cancer growth? Targeting the AMP-Activated Protein Kinase for Cancer purpose?

Peatbot: Yes, vitamin E has undergone significant changes over the years. Originally, vitamin E was produced using methods that resulted in a product that was thick, viscous, and often brown in color. This form of vitamin E was associated with beneficial effects, including anti-estrogenic and anti-clotting properties, and was thought to protect against the toxic effects of polyunsaturated fatty acids (PUFAs).

However, over time, the manufacturing processes for vitamin E have changed. For example, when ADM bought the old Eastman distillation products factory, they altered the methods of production, which affected the consistency and appearance of vitamin E. The newer vitamin E products became more diluted, often with soybean oil, which is highly unsaturated. This change in formulation has been linked to a reduction in the beneficial effects that were observed with the original vitamin E products.

Additionally, the perception and definition of vitamin E's role have evolved. Initially, it was recognized for its fertility-enhancing and anti-estrogenic properties, but later it was primarily marketed as an antioxidant. The changes in manufacturing and formulation have led to variations in the effectiveness and safety of vitamin E supplements, with some studies suggesting increased mortality associated with certain formulations.

Overall, the form and quality of vitamin E have shifted, and these changes have influenced its perceived health benefits and risks.

Peatbot: Yes, vitamin E is generally considered safe to take on a daily basis, especially when taken in appropriate amounts. The context suggests that about 30 to 50 milligrams per day can provide full protection. However, it's important to choose a high-quality vitamin E supplement, preferably one that contains mixed tocopherols, as these are anti-inflammatory. It's also noted that vitamin E is particularly beneficial if you are consuming polyunsaturated fatty acids (PUFAs), as it can help counteract some of their negative effects.

@SpaceManJim Depends when you ask. Right now it’s NDT.

@Mauritio
If high dosing thiamine, also watch out for magnesium issues, potassium (I rely on OJ), zinc, riboflavin (yes!).