@Chris2401

Of what I understand.
They make a supposition.
Ovarian removal operation (OVX) induces a lack of estrogen, like in age-old-years, pretending it induces a decline and a neurodegenerative process.
They make a correlation: iron accumulates with time. Excess iron is creating ROS.
Female rats have showed decreased dihydroorotate dehydrogenase (DHODH) expression when getting under OVX.
However DHODH supports a vital role in neuronal ferroptosis.
But E2 alleviates ferroptosis induced by erastin and ferric ammonium.
So, if we try to link:
a) OVX + neuro-decline + lack of estrogen
b) Excess iron in menopause + lack of estrogen
=> If A induces B, and if C induces B, A should equal C.
If excess iron induces ROS and lipid peroxidation, take the way back and get estrogen to cancel the decreased DHODH induced by ovarian removal operation (OVX).

How does iron cause ferroptosis?
Taken together, excess iron in both the cytosol and mitochondria significantly contributes to the development of ferroptosis in neurodegenerative diseases, and this occurs primarily through its promotion of oxidative stress and lipid peroxidation.

Note1: One correlation seems to give an analogy but not an equivalence. Expressed differently, pharma tries to find positive effect to supplementing E2, event by arranging or inventing improvements.
Note2: Estrogen is not directly linked to ROS. Iron is linked to ROS and ROS induce membrane peroxidation.

@Ornamento said in What's this brightness around the eyes?:

it was all around the eyes, and it made disappear a bit the bags. It was like a sort make up.

vitiligo around the +eyes ?
It could be vitiligo (no melanocyte to color the skin). Not sure because the description given doesn't match with brightness white. In vitiligo it's rather pale white / light brownish skin (absence of brown color). We don't really know why.
https://my.clevelandclinic.org/health/diseases/12419-vitiligo
PS: It's difficult to say yes or no. Not sure before seeing a dermatology practitioner.
usually, it doesn't disappear and comes back afterwards.

try massaging, foam rolling, stretching, moving around different parts of your body to see if you can find a knotted tight spot that may be referring pain.

just pay yourself for the type of imaging you think you should get anyways. you can probably find somewhere to pay for an ultrasound too. maybe there's some pregnancy clinic or something you can pay cash at

Follow-up/ update: I’ve looked into this a little more.

BDDE is the cross linking agent that they use to make the filler more durable. I’m going to look into taking care of that.

Beyond that, some people have set that the filler creates fibrotic tissue, and anti-fibrotic agents are being used by doctors to treat fillers. So that’s definitely a potential method for treatment, and I’m currently looking at Dissolve-It-All, DeFibron, and Ray’s healing marmalade.

I also think (just from my own experience and observations) that calcification is involved. Mainly because I’ve been seeing the are and my overall face shape improve after regularly taking more vitamin K.

Last, water retention seems to be a key element to this. I believe hyaluronic acid affects water regulation and causes some edema and swelling. I think that is a mechanism that the filler uses to “plump up”. Estrogen (opposing it) and potassium (supplying sufficient amounts) are going to be focuses here, with more future considerations.

That’s all for now. Trying to learn and get help as much as I can

@BaseBornPeater Eating liver the first time after being vegan 2 years was life changing

@LucH thanks dude

@sneedful The ratio to calcium is what matters more

@himblondemaxxing - You might want to stay the course and use the rest of your supply. It is not clear to me that the product purchased from Farmacia Del Nino or the warm weather has caused you to question your purchase.

@RawGoatMilk88 said in If t3 supplementation is low enough <25mcg, does the thyroid continue to function?:

If t3 supplementation is low enough <25mcg, does the thyroid continue to function?

Given what Ray said below, I doubt it’s enough to fully suppress the thyroid:

“As long as it's divided so that you don't get a big dose of T3 all at once it should be o.k. to take a total of 25 mcg T3 and 100 of T4. That would be similar to the traditional 2 grain dose of Armour thyroid. A healthy person should produce the equivalent of about four grains per day, so with 2 grains of supplement, or the equivalent, there isn't a risk of over-dosing.”

However, even if it did, Ray said this:

“Experimenters using isotopes gave large doses of thyroid until the subjects' glands were completely shut off, and when they stopped giving the doses, everyone's gland returned to normal activity in just 2 or 3 days. The gland is extremely quick to adjust its activity, both up and down, except when it's inhibited by stress, or PUFA, or estrogen, etc.”

https://raypeatforum.com/wiki/index.php/Ray_Peat_Email_Exchanges#Thyroid_Hormones

@Serotoninskeptic, yep! I use the PS’ gelatin in my dad’s meals and the collagen in his coffee.

@aquarice
fruit, milk, reducing PUFA, and natural sunlight should 100% help.

@jhp Will do, I'll probably do 8 drops about 60 minutes after taking the tabs.
I also have Cypro with me, mixing the 3 is for another day though.

@GreekDemiGod In Celsius I get around 97- low 98 temps sometimes my temps go as low as 96 though. I just want to know how , and with what I should be measuring. Im not sure how bad my thyroid is I do sort of have no lunulae and my nails are pink/purple. I also get cold after meals.

@winters

Not sure but I'm guessing it would be because nearly all other minerals or metal minerals can be deficient and cause problems.

I think what is difficult is to interpret cravings. Trying to limit and remove seed oil / pufa I've noticed I don't actually crave those things as much. Like, I'm not eating fried chicken or fried stuff much anymore. I like Chinese but really limit stuff like this and don't crave it so much.

However I ate some good dark chocolate and couldn't get enough of it... I think you may be onto something.

7048c9ae-ed5f-4d11-a387-57102cc419dd-image.jpeg @bbran

Are there any safer options?

@NateHiggers
Depends on the dose, if 1ml then 50 doses, if 0.5ml then 100 doses.
Yes i ship internationally and yes it is discreet.
The powder is from QSC, tested at Janoshik and came back at 98+% purity.

Frank Sinatra was known for his eyes
Very-Young-Frank-Sinatra-frank-sinatra-5928131-600-755.jpg

My poll was voted on and I forgot to check:
https://lowtoxinforum.com/threads/oxidized-cholesterol-vs-pufa.28333/

Which one is worse? Oxidized Cholesterol vs Polyunsaturated Fatty Acid

I watched the whole vid, was intrigued from the first few mins when he described a very intuitive and somewhat Peat-related approach: lots of carbs, lower stress, high agency lifestyle. He then goes into his staple meal being red meat and rice, plus unlimited fruit, which seems like a pretty solid way to run one's diet.

But it also made me think about how just being active every day is such a huge factor in one's body composition. This guy, like many YT fitness influencers, don't have "real" and sedentary jobs, including stressful commutes. They just live a "more natural" life, are on their feet way more, always moving, don't have low-grade stress associated with constant use of Microsoft Office products (lol!).

I've noticed this effect pretty pronounced in myself. I'm an office worker by day with side business ambitions I work on during evenings and weekends when possible, so it's a lot of 'modern day office work'. I also do intense weight training 3x a week and a few bouts of cardio via martial arts, so I'm in reasonable shape - strong with slightly visible abs and ~15% bodyfat.

But when I'm not working, not having an alarm clock, for extended periods of time, my physique just takes on that extra ~25% of quality that's hard to describe - everything feels and looks tighter, more abs visible while at same body weight, energy levels and lifts are maybe 10% better automatically, etc. I tolerate any and all foods way better too. I really get the sense that if I focused on living life this way for more than a few weeks on vacation here or there, I could be making these dumb "here's my life as a fitness guy" videos lol. Just being on my feet walking some European city on vacation for a few days does incredible things compared to standard north American life, and people like Bill live closer to the former than the latter everyday.

Not meant to brag, but rather to say that I believe most anyone could quickly and continuously improve their physique and physical well-being if they make appropriate trade-offs in life. And I'm sure those of us stuck in the corporate North American grind can continue to find and apply principles to improve our health and fitness too.