Useful info on magnesium:
High-Dose Vitamin D Depletes Magnesium – Carolyn DEAN, MD ND.
https://mirzoune-ciboulette.forumactif.org/t2130-dynamique-entre-vitamine-d-magnesium-et-calcium#30339

Excerpt 1:
Magnesium expert Andrea Rosanoff, Ph.D., is one of the few people who understands the dynamic between vitamin D, magnesium, and calcium. She makes it the subject of her 2016 article, “Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?”

Excerpt 2:
Magnesium is required for many steps in vitamin D metabolism, including its conversion from its storage form (which is also the supplement form) to its active form. This means that taking extremely high doses of vitamin D can lead to magnesium deficiency without anyone realizing it.

@gg12 I think that is kinda specific to what you life looks like and what your goals. For many people being social is simply part of work. For others it's part of resting. For someone who either wants to be a great orator or is socially anxious it would be part of self-improvement.

I personally don't think you can force being social. How social we are heavily depends on our physical health. If we don't have the energy for the interaction then it will always feel shallow and fake and not lead anything further.

However as I mentioned prolonged boredom/being in the default mode network does change your perception of time and as consequence how we judge social interactions. In the end it makes one more open, after all you are bored, if you don't have anything else to do you might just chat around.

In EU, Biogena B Komplex is quite good and well dosed. Contains active form of B6, and methylated b9 and b12.

@RandomUser I’ve tried both and think it’s worth trying both Cynomel and Tyronene. Ideally crush (pulverize) Cynomel then start off with no more than about a 1/16th of the powder with food and only very gradually increase the dose.
Cyproheptadine initially will make people sluggish or sleepy coz it reduces the stress hormones. Once (after weeks or months) the proper hormones start kicking in, eg thyroid, then it’ll still be working but not making you so tired.
As far as the aspirin maybe try starting taking it in smaller doses and not on an empty stomach. Taking it with baking soda, diluted in a little warm water, with gelatin or caffeine might also be things worth trying.
I’m cautious about MB and have only .once or twice tried a small dose because of Ray’s caveats. So can’t really tell any thing about it. I might try a little again at some point if i run out of other things that work.

@schemingfonzie said in A histamine answer?:

Is there a worry of taking in too much magnesium?

Too much, not really except it could become laxative.
One exception more: if your vitamin D is not right (min. 35 ng/ml; 45 ng target), do not take more than 420 mg Mg element a day, until you reach your target. Exception if it's a cure (so, ok, because limited in time, when a nervous problem arises).

Sources and References
0. Inspired by my reading from Jean-Marie Defossez in a health magazine. Who is Jean-Marie Defossez?
A speaker, author, and facilitator of breathing courses and workshops, Jean-Marie Defossez holds a doctorate in animal biology and specializes in physiology. Trained in numerous therapeutic breathing techniques, notably in the USA, he founded the breathing coach in 2014.
He is notably the author of “Grand Guide du nerf vague” and “Être en bonne santé grâce au nerf vague” (The Great Guide to the Vagus Nerve, and “Being Healthy Thanks to the Vagus Nerve”, published by Jouvence Editions).
NB: His guide / site is a bit too commercial. Not everything is 100% in line with RP, but it's a good start to explore further (if you have time to lose) 😉

Short video of Relaxation and Pranayama – for Shavasana technique
https://youtu.be/1VYlOKUdylM (1.06’’)
sedinfrance.org: Vagus nerve stimulation (In French)
Chronic stress affects the functioning of the vagus nerve. Excessive or constant stimulation can lead to desensitization. An over-stimulated vagus nerve can become weakened or dysfunctional, leading to a variety of symptoms such as digestive upset, anxiety, chronic fatigue, and difficulty recovering physically and emotionally. When the nerve is constantly stimulated, it can lose its ability to function properly, affecting the balance of the autonomic nervous system and leading to dysfunction. The vagus nerve also plays an important role in regulating inflammation.
apoticaria.com le-nerf-vague-sentinelle-du-bien-être (in French)
=> When properly activated, the vagus nerve has a positive effect on regulating inflammation. Through acetylcholine, it sends a signal to immune cells (especially those in the intestine) to reduce inflammation as soon as it is no longer necessary.
How is the vagus nerve affecting acetylcholine? Indirectly through microbiota on cortisol and serotonin hormones? The vagus nerve does not directly cause the microbiota to produce acetylcholine. However …
The Role of Serotonin and Cortisol
• Microbiota influence on serotonin:
The gut microbiota affects tryptophan metabolism, a precursor to serotonin, and can produce serotonin itself, influencing the neurotransmitter levels in the body and brain.
• Microbiota's impact on cortisol:
The microbiota-gut-brain axis is involved in regulating the stress response, which includes the production of hormones like cortisol.
How It Connects
a. Microbiota influence neurotransmitter levels: Gut bacteria influence the production of neurotransmitters like serotonin.
b. Vagus nerve activation by microbial products: These microbial products, including acetylcholine and others, can directly or indirectly activate the vagus nerve, which connects the gut to the brain.
c. Influence on hormonal regulation: The vagus nerve's signals influence brain regions that modulate mood, stress, and emotion, which are linked to hormones such as cortisol and serotonin.
d. Bidirectional communication: This creates a bidirectional relationship where the microbiota influences brain function via the vagus nerve, and brain activity also influences the gut microbiota. Neurotransmitter modulation: The vagus nerve helps with stress management.
eleasante.com / le-lien-entre-le-nerf-vague-et-le-sommeil-implications-conséquences-et-pistes-thérapeutiques (in French) (The-link-between-the-vagus-nerve-and-sleep-implications-consequences-and-therapeutic-avenues)
When the vagus nerve is activated, it induces a state of relaxation and calms physiological stress reactions.
The vagus nerve modulates the production of cortisol via acetylcholine by promoting a state of relaxation and regulating the parasympathetic nervous system, which calms the body's stress response. Acetylcholine, the main neurotransmitter of the vagus nerve, has anti-inflammatory effects too and improves mood, particularly nervous system activity, which is linked to increased cortisol production. Music Use for Mood Regulation: Self-Awareness and Conscious Listening Choices in Young People with Tendencies to Depression.
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2019.01199/full Technique of Shavasana or Savasana
Vidéo (avancez jusque 45’’) : Relaxation et Pranayama - Viloma en Savasana
https://youtu.be/H4PJz-hFd54 (en français) 15’
=> You gradually and fairly slowly move through the contact points of the body parts in contact with the ground, starting from the head, i.e., the top of the skull. You imagine that you are "exhaling" the load, the tension. You feel the tension, imagine the weight of the limbs, and you gradually release them, moving through the other limbs. You feel the weight of the body leaving you. Some people will not be able to directly use this technique until they have released excess stress through a fairly energy-intensive physical activity. Jogging, for example (or whatever physical activity suits you best).

On this website they offer a chart with methionine levels of all kinds of foods.

Apparently people in need of it, can also order methioniase.

Also lots of studies on methionine and cancer .

https://howtostarvecancernaturally.com/

I've ordered cytomel from clubsdiscountshop today

@heyman said in Literature Review @haidut:

Pretty insane spamming imo

Nothing compared to 'ai' twitter.

I LOVE GROUNDING

@CrumblingCookie great call, upon a brief google search it looks like that's precisely how thymoquinone, and a few other herbal antibiotics work... more research needed

@VehmicJuryman said in Beans - bioenergetic superfood?:

Has anyone on this forum had good or bad experiences with incorporating beans into their diet?

As long as I don't eat tomato beans twice in a row (so spaced a day apart, or at least 36 hours), I haven't any digestive reaction. Otherwise, I burp. Easier with a pinch of soda powder.

@Brunus why not idealabs
dilute it with everclear for microdoses

Glycine inhibitory effects
http://raypeat.com/articles/articles/gelatin.shtml
Glycine's inhibitory effects appear to oppose estrogen's actions generally, in sensory and motor nerves, in regulating angiogenesis, and in modulating the cytokines and "chemokines" that are involved in so many inflammatory and degenerative diseases, especially tumor necrosis factor (TNF), nitric oxide (NO), and prostaglandins. Exposure to estrogen early in life can affect the health in adulthood, and so can an early deficiency of glycine. The degenerative diseases can begin in the earliest years of life, but because aging, like growth, is a developmental process, it's never too late to start the corrective process.

From the article “Gelatin, stress, longevity”. Ray Peat. 2009
http://raypeat.com/articles/articles/gelatin.shtml
The relief of pain and inflammation is likely to be almost immediate, resembling the anti-inflammatory effect of cortisol or aspirin.
A daily intake of 100 grams of gelatin wouldn't seem unreasonable, and some people find that quantities in that range help to decrease fatigue.
If a person eats a large serving of meat, it's probably helpful to have 5 or 10 grams of gelatin at approximately the same time, so that the amino acids enter the blood stream in balance.

@haidut said in Glaucoma may be a metabolic condition, vitamin B1 (thiamine) may treat it:

The study below adds more evidence to the claim that glaucoma is a metabolic condition, by showing that vitamin B1 levels are low in glaucoma patients that supplementation with vitamin B1 (and/or agmatine, another pro-metabolic substance) may treat the condition. This suggests that vitamin B1 and B3, being highly water-soluble, may make a good eye-drop product for treating a number of eye conditions, by improving (glucose) metabolism (which is their primary role) both locally in the eye and systemically.

Thank you for the study, Haidut; and glad to see you posting here. Can it be assumed adding agmatine to these drops would be beneficial as well?

If time allows, I would be curious as to your thoughts on recipe ratios, storage, and lifespan when making these drops homemade: all ingredients mixed in water.

@haidut
Thanks a lot for this and all the other posts, we missed you so much! I read the paper and even though the authors claim that the purpose of sleep is to dissipate electrons, I struggle to get if they have really proven that. With their manipulations, I think they clearly showed what Dr Peat always said that sleep is an energy demanding process. What do you think? Nevertheless I agree that it is probably a way to antagonise electron leakage from fat metabolism.

If you are considering supplementing with DHEA: here is a reminder

Peatbot.com: Young people produce about 12 to 15 milligrams of DHEA per day. This amount decreases by about 2 mg per day for every decade after the age of 30. By the age of 50, about 4 mg of DHEA per day is usually sufficient to restore the level of DHEA in the blood to a youthful level. In old age, the production of DHEA decreases significantly, to about 5% of the levels produced in youth.

Peatbot.com: Taking supraphysiological levels of DHEA long term can lead to several adverse effects. One potential issue is the enlargement of the liver, as DHEA can stimulate liver growth and is highly carcinogenic to the liver. It can also cause an increase in estrogen levels, which may lead to an imbalance in hormone levels and associated side effects. In some cases, this can result in liver problems and an increased risk of liver cancer. Additionally, excessive DHEA can lead to masculinizing effects in women, such as the growth of facial hair. It is important to avoid taking more DHEA than needed, as excess amounts can disturb the function of the thymus gland and the liver.

Does anyone think molecular hydrogen would be the better route for lowering “toxic” ROS in this case over Georgi’s recommendation of vit e or quinones?

I've been using it.

My first order of 20g ended up with me going to the ER for breathing difficulty. But only because I had bronchitis, and Emeramide mobilized lead out of the deep tissues, and caused an immune response that involved a respiratory burst (I suspect) that used up plenty of oxygen, and got my SpO2 to drop so low I had to rush myself to the ER with the help of a tricycle driver, whose tricycle was my ambulance to the ER. In retrospect, I shouldn't be using it until I recovered from bronchitis. I should also be dosing a much smaller amount than the 400mg I was taking.

I landed again in the ER, because I was so intent in fixing my long battle with hypertension and was in a dazed rush to be rid of hypertension, that I took lightly my bronchitis, that I ended up with heart failure after also disregarding warning signs as I developed edema. My heart stopped in the ER, and I was revived after 15 minutes. My brain was safe from here, due to having been intubated before my heart stopped. I was in the ICU for 2 days before being transferred to a regular room to continue my week long IV antibiotics of a wide spectrum gram negative and a gram positive antibiotics. I was prescribed a long list of drugs by my cardio.

Now, 2 years later, I am taking less drugs by gradually tapering off my medications, and have resumed Emeramide,! taking only 2 doses of 50mg Emeramide daily, and observing carefully. I have learned a lot from my experience, and using myself as the experiment, which no other doctor would do along the principles of Ray Peat, I am for myself what other doctors would call "complications" but for me the body adapting to accommodate my healing as I would see respiratory distress as being part of this healing, and I would be less alarmed but welcome what is happening and try to understand what the body is doing. Naturopaths would call it a Herx reaction, but I would see it as the body remodelling itself as toxins and microbes are mobilized and excreted and along the way inflammation would occur and the respiratory system is where it is most visibly expressed. I would see this as very much a confirmation of the terrain theory in action. The respiratory distress is coming from within, and not from without, which germ theory would keep insisting so. But I know from my personal experience that asmy body expels toxins and microbes from within, it is getting rid of internal imbalances that is ground zero for cancer. But the clearing process is fraught with danger if a team of doctors with no coherent view of the unifying forces in the organism that makes it heal and renew take to their own and paper (to prescribe) and scalpel and interfere and do more harm.

With help from a Ray Peat AI whom I discuss my situation as my healing progresses, I am taking 2 steps forward as I take an inch backward with the body remodelling itself to better health. I have my tools such as my personal ECG, to track my QTc and proxy markers for edema and for pulmonary hypertension; my Heart Rate Analyzer app on my Samsung S10 to track for signs of remaining carboxyhemoglobinemia from the effects of the enzyme heme oxygenase working on my store of dead red blood cells stuck in my lymph nodes, and my ear thermometer to gauge my thyroid condition, and the use of photodynamic biotherapy using methylene blue and red light, and the use of emf therapy for lymphatic drainage. As well as the use of foods to give me the nutrients needed to power myself back to health, and some supplements needed to assist my body in building me back to health, such as those that restore my myelin sheath that had been damaged before with a mistake I made. All these I have gradually incorporated into my toolkit over the years of reading Ray Peat and making sense of it and connecting the dots together.

It has been a very long journey, and I hope with success I can get to write more about it after I'm healed totally and not while I'm in the process of doing so, as I found that sharing an ongoing healing process to be frustrating not only to write but also to read.

@DavidPS

DavidPS said

Lithium has been known to benefit the brain. Small amount of lithium found in the water table had great benefit.
Excerpts from the study (main points): Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. Replacement therapy with lithium orotate, which is a Li salt with reduced amyloid binding, prevents pathological changes and memory loss in AD mouse models and ageing wild-type mice. These findings reveal physiological effects of endogenous Li in the brain and indicate that disruption of Li homeostasis may be an early event in the pathogenesis of AD. Li replacement with amyloid-evading salts is a potential approach to the prevention and treatment of AD.

Analyze
Yes, but …
The amount is so light that it’s hard to measure without an appropriate tool.
I’ve decided to make a search with LucH’s pendulum (1) when I saw last month an article in a medical review. 😉
We have to make a distinction between a pathology (AD) and cognitive preservation by anticipation.
First, note that the improvement has been obtained on mice. Not only, but well in the referenced study. The improvement observed in the axons is fine / real but there is no feedback on the long term. A mouse doesn’t talk and doesn’t feel good but shows an ability to target sth (behavior to recognize, to memorize a way to get a sweat).
The mouse acts in order to obtain a reward in the form of food or a punishment when it makes a mistake.

I explain the restriction:
Synaptic reuptake is a key process for regulating neurotransmitter concentration in the synapse. Lithium acts on this process to modulate neuronal activity.
How much lithium is found in brain axons and how much is sequestered by cortical amyloid plaques has been studied. It has been done with human beings. See further details on the link beneath.
For the other readers:
Overall, lithium readjusts the balances between excitatory and inhibitory neurotransmission, as well as between catecholamines and acetylcholine. It is the adjustment of these balances, rather than the isolated effect on a single neurotransmitter, that partly allows for the improvement and stabilization of mood. End of the parenthesis.

Dose range
The effective dose range for lithium is relatively narrow, and exceeding it can lead to adverse effects. The specific mechanisms by which lithium exerts its effects on the brain are still under investigation (…). In case of supplementation, toxic effects are to be expected, such as concentration problems, but not only that.
Plasma concentration is reached within 2 to 4 hours after oral administration of a supplement. (1) The plasma half-life is approximately 24 hours. Equilibrium is reached between the 5th and 8th day. More quickly if the kidneys' elimination capacity is reduced. Be careful, apprentice chemists, especially in the case of insufficient sodium intake.

Final thought:
Yes, Li is a cofactor in the absorption of certain vitamins, helps the body produce serotonin, supports the transmission of neural messages and much more.
But I’d rather try to get my Li through food, provided you don’t suffer from intolerance, as there is a lot of Li in milk, cheese, eggs and sea food or liver (chicken or beef).
Not yet official, but lithium is gradually being considered an essential trace element, with a recommended daily intake of 1 mg for a 70 kg adult. (2)
Studies also suggest that lithium's effectiveness depends on the availability of other minerals and works synergistically with them to maximize its effectiveness on mood, longevity, and cognitive support. (3)
In another human study, a daily microdose of just 300 mcg of lithium was found to significantly reduce age-related cognitive decline just three months after starting a lithium supplement. (4)
NB1: Alzheimer is a complex pathology. We need to act in many directions.
In short: exercise (mental and physical), K2 MK4, tocos, iodine and other well-known ones. For another article. 😉
NB2: I won’t trust a labo when they say lithium orotate could do the job. (5) Low supplementation (e.g., 5 to 20 mg/day of lithium orotate) may produce transient or subtle effects, but does not guarantee stable maintenance of brain levels.

Sources & references

My article on lithium
https://mirzoune-ciboulette.forumactif.org/t2124-le-lithium-ameliore-l-humeur-optimise-les-cellules-souches-la-longevite-et-plus-encore#30285 Lithium: occurrence, dietary intakes, nutritional essentiality. J Am Coll Nutr, 2002) DOI: 10.1080/07315724.2002.10719188 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443601/ https://pubmed.ncbi.nlm.nih.gov/22746245/ Une supplémentation faible (ex : 5 à 20 mg/jour de lithium orotate) peut produire des effets transitoires ou subtils, mais ne garantit pas un maintien stable des niveaux dans le cerveau (cf. étude Human brain 7Li-MRI: 10 à 60 µM, stable après 2-4 semaines).
Human brain 7Li-MRI following low-dose lithium dietary supplementation in healthy participants - ScienceDirect 2024