@anub
Hi,
Things to be taken into account.
Get informed on deiodinase action too because you could lack some useful nutrients like iodine, magnesium, or event zinc if you don’t eat meat.
If you eat carbs from cereals at 3 meals, you lack thiamine (B1).
From Google AI:
Thiamine (Vitamin B1) impacts dysautonomia by being essential for energy metabolism in nerve and muscle cells, and its deficiency can cause or mimic autonomic nervous system (ANS) dysfunction. Symptoms like fatigue, dizziness, and muscle weakness, seen in thiamine deficiency, also occur in dysautonomia. Correcting a thiamine deficiency with supplementation can lead to significant symptom relief in some dysautonomia patients
See Elliot Overton (nutritionist) if you want confirmation on dysautonomia (3) and Dr. Antonio Constantini (neurologist).
Note that some people aren’t suffering from what we call a nutrient deficiency but from a metabolic block. Dependent-B1 enzymes are blocked / inactivated due to some “stress factors” (see figure): chemical and environmental toxins, chronic inflammation and infection.
Figure: Thiamine-dependent enzyme blocked in the metabolism
Thiamine-dependent enzyme blocked.png
KGDHC = α-ketoglutarate dehydrogenase complex = dependent-B1 enzymes.
Credit: Elliot Overton (nutritionist) and Dr. Antonio Constantini (Italian neurologist)
Warning: When taking high dose thiamine, there is a protocol to follow. There is interaction with other vitamins. For example taking 100 mg, then afterwards 500 mg of thiamine (the TTFD kind is advised for the brain penetration) will deplete the other cofactors involved in the assimilation of thiamine.
Useful links
https://mirzoune-ciboulette.forumactif.org/t2108-english-corner-taking-t3-and-t4-synthetic-supplement-improves-metabolism-for-a-while#30193
=> Roles of deiodinases. Required nutrients for thyroid health. Time adaptation is required
=> "Since the body normally produces about 4 mcg of T3 in an hour, taking 10 or 20 mcg at once is unphysiological" - Ray Peat
“With too much t3 the liver starts converting any T4 into reverse-t3”. - Ray Peat Brain Regions affected by thiamine deficiency
How to Apply High-Dose Thiamine Protocols in Clinical Practice: Part 2
Practical Guidance
https://www.youtube.com/watch?v=RFZUzS_xP9A
EONutrition – Elliot OVERTON (nutritionist) (multiplex) – Part 2 – Video 2:04:02
This is the second of two lectures I gave to a group of medical/health professionals on the clinical application of high-dose vitamin B1. In this video I outline the difference between nutritional deficiency and the concept of "functional dependence". I then discuss the practical aspects of forming a protocol including: - Which form to use and why - How to dose for different conditions - When to use this therapy and when not to use this therapy - Managing patient side effects.
*) 10 hallmarks of the video
0) 1.45”: recap of part 1.
*) The Art and Science of Mega-Dose Thiamine Lecture: Part 1 – Video 1:34:21
https://www.youtube.com/watch?v=-Uf1D2KdTn0
EONutrition – Elliot Overton (nutritionist)