The relationship between Candida infections and heavy metal toxicity

DavidPS

@Mauritio - no. Professor Exley recommends silicon water.

Silicon-Rich Mineral Water as a
Non-Invasive Test of the ‘Aluminum
Hypothesis’ in Alzheimer’s Disease

Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease

DavidPS

@Mauritio -see also
https://bioenergetic.forum/topic/769/silicon-deprivation-decreases-collagen-formation-in-wounds-and-bone-and-ornithine-transaminase-enzyme-activity-in-liver

cs3000

@Mauritio
hi yeah likewise

on MOA [first i read apple pectin can increase absorption of some polyphenols (e.g quercetin 2x) where other polyphenols get hindered. but as typically small amounts in food i wouldnt expect to make that much difference from double absorption probably not very relevant]

So likely through preventing re-absorption in the gut from bile & mucosa shedding is enough for significant effect without doing it direct in the bloodstream (for certain metals)

maybe optimal to do a blend of both modified form + apple form for different mechanisms and skew towards different metals? Looks like lead is a commonality, (might lower copper a lot too tho, but less so in presence of lead "Lee and Yang (1997) studied Cu binding by pectin rich apple waste and found that ionic strength did not cause significant differences in metal ion binding capacity.
They also found that the presence of co-ions such as lead decreased the removal of Cu due to competition")

This one mentions mechanism of action being preventing reabsorption with bile that circulates

A blend of citrus & apple pectin also reduced pesticides in blood to almost 0 https://www.romj.org/2013-0306

On the base of the research we can ascertain that citrus and apple pectin “Medetopekt” reduce resorbtion of heavy metals and organochlorine pesticides, accelerate eliminating of these substances from an organism.
It is well known that organochlorine pesticides are eliminated from an organism with bilis, and pectins bind bile acids in intestine, and by that cause eliminating of pesticides. Insoluble compounds in natural enterosorbents improve intestinal function. Moreover, at acute chronic pancreatitis pectins reduce hyperenzymemia

I was thinking maybe modified form would be better for mercury seeing mercury is sticky in the brain. but study here said apple pectin also helped reverse mercury toxicity https://pubmed.ncbi.nlm.nih.gov/10198961/ and functional impact
(russian translation "vegetative regulation" looks like it means nervous system measures improved from the apple pectin removing mercury e.g heart & reflexes https://pubmed.ncbi.nlm.nih.gov/26369239/

@questforhealth interesting connect about the marmalade yeh , i read a case report where some woman was intuitively eating like 20g salt worth of soy sauce and lots of licorice each day , which turned out was keeping her body functioning in a disease i think it was addisons

Heavvy metals must mess with the brain so bad

Peoples voices and music are starting to sound different in my life, like they have a depth I never knew about??

Whatever this stuff is doing the impact on my life is good

Just sad I didn't do heavy metal test before & after. Might do that for aluminium if I have the energy. But it does cost some money. Better focus on cheap and easy.

Santosh

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

Heavvy metals must mess with the brain so bad

Peoples voices and music are starting to sound different in my life, like they have a depth I never knew about??

Whatever this stuff is doing the impact on my life is good

Just sad I didn't do heavy metal test before & after. Might do that for aluminium if I have the energy. But it does cost some money. Better focus on cheap and easy.

Just buy some Emeramide and go on with your life, no ?

Amazoniac

Antifungal Activity of Stabilized Ortho Silicic Acid (OSA) against Foliar Plant Pathogens

You can find more related material, and it may be relevant for humans.

@Santosh

Pectin is gentle and natural. These days I like nature and sun and picking my own herbs outside more than buying shit off the internet.]

@Amazoniac

That is genius. Maybe if I ever started farming I could spray this stuff on the crops and people would be getting medication along with their food....

Mauritio

@DavidPS said in The relationship between Candida infections and heavy metal toxicity:

@Mauritio -see also
https://bioenergetic.forum/topic/769/silicon-deprivation-decreases-collagen-formation-in-wounds-and-bone-and-ornithine-transaminase-enzyme-activity-in-liver

Thanks for sharing, so silicon is needed for collagen synthesis and wound healing.

Mulloch94

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

Pectin is gentle and natural.

Some people do have exceptionally bad digestive disturbances with pectin. I think the best chelators are cilantro extract and succinic acid. Neither will really disturb the gut too much.

Mauritio

@cs3000 said in The relationship between Candida infections and heavy metal toxicity:

This one mentions mechanism of action being preventing reabsorption with bile that circulates

This strikes me as the most likely, since apple pectin is good increasing bile.

"Fecal bile acid excretion (+168%) and the hepatic activity of cholesterol 7alpha-hydroxylase (+70%) were significantly higher in pectin-fed animals. "

https://pubmed.ncbi.nlm.nih.gov/8683337/

And most heavy metals are reabsorbed via bile.

Also good to know that pectin will preferentially excrete lead instead of copper. Apples for the win, again!

96.2% of the soluble fibers of carrots are pectin as well.

Do you know what an effective dose would be for heavy metal removal with pectin ?
Btw marmelade contains about 5g/kg.

Mauritio

@Mulloch94 said in The relationship between Candida infections and heavy metal toxicity:

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

Pectin is gentle and natural.

Some people do have exceptionally bad digestive disturbances with pectin. I think the best chelators are cilantro extract and succinic acid. Neither will really disturb the gut too much.

I know peat was no fan of succinic acid, because we have no idea where the heavy metals are redistributed to...potentially worse places in the body?
Not sure if he would have said the same thing about pectin. That's why I originally went with MCP as it has a different mechanism of action, that is safer.

But after all this info on pectin Im considering trying that out as well.

Mauritio

"More specifically, fruit juices were more likely to have Pb in the samples: 89% of grape juices, 67% of mixed fruit juices, 55% of apple juices, and 45% of pear juices, attesting to the differential risks based upon the type of food ingested [7]."

@Mulloch94

Works for me

Succinic acid just made me feel so stupid, like I was being poisoned, fried brain, I was actually scared I wouldn't come out of it

Mulloch94

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

Works for me

If it works it works. I was simply suggesting to use with caution. It's a type of fiber that feeds intestinal bacteria, and can cause issues in some people.

@Mulloch94

Aye well worth being careful

I might chef something up.. Metal detox meals using all the info on this thread... I feel it might be really good

Mulloch94

@Mauritio said in The relationship between Candida infections and heavy metal toxicity:

Try cilantro extract, it's my personal favorite. Never had any adverse effects from it. The one word of caution is it's a anticoagulant, so probably shouldn't combine it with aspirin or serotonin antagonists.

Not sure if he would have said the same thing about pectin

Ray didn't like pectin either. But you need to use whatever works. Don't get too caught up into something Ray said about a particular product. That's where a lot of people on the other forum messed up at. The only real thing to be mindful of is if the use of a certain substance moved you toward oxidation or back into reduction. The how-to's will lack and/or defy any preconceived blueprint.

@Mulloch94

Yeah wasn't peat about what's cheap and what we can easily get after all

I might try eating more marmalade and jam soon. I think when you are very toxic though you do need to bring in the 'heavy artillery' at least at first.

Mulloch94

@questforhealth Yeah, he didn't really give out any official recommendations because it would look profoundly different for every individual based on uncontrollable things. Existing medical conditions, food allergies, economic status, geographical location, etc. they all play an important role in health maintenance that other lifestyles simply choose not to acknowledge.

Hypothetically, I'm sure if we were to devise a optimal "Ray Peat diet" it actually wouldn't look anything like what those orthorexics on RPF would do.

It would be something like living in the high elevation of South American mountains, coming down daily to buying the freshest most ripe tropical fruits at markets, and getting fresh never frozen animal liver, milking sheep on the mountain tops, gathering free range eggs, hunting fresh oysters on the seashore. Basically impossible shit, lol. But it certainly wouldn't be a diet consisting of only store bought milk and OJ.

cs3000

@Mauritio said in The relationship between Candida infections and heavy metal toxicity:

This strikes me as the most likely, since apple pectin is good increasing bile.

"Fecal bile acid excretion (+168%) and the hepatic activity of cholesterol 7alpha-hydroxylase (+70%) were significantly higher in pectin-fed animals. "
https://pubmed.ncbi.nlm.nih.gov/8683337/
And most heavy metals are reabsorbed via bile.
Also good to know that pectin will preferentially excrete lead instead of copper. Apples for the win, again!

96.2% of the soluble fibers of carrots are pectin as well.
Do you know what an effective dose would be for heavy metal removal with pectin ?
Btw marmelade contains about 5g/kg.

so clears bile and increases its synthesis to try to balance, ah marmalade not great then
apple pectin at ~5g split twice a day i think for an adult should do it, 1-3 week course for significant effect (15% -16% actual pectin content of the powder used here in children, in another paper by them it mentioned i think children aged 5 - 17 or something , so maybe 3x dose would cover that)
https://www.researchgate.net/publication/8900434_Reducing_the_137Cs-load_in_the_organism_of_Chernobyl_children_with_apple-pectin

In the other study the apple + citrus combo showing effects on lead & cadmium , in the pesticides part of the study was ~3g pectin total a day split 30 min before meals. for the metals they used high dose 6.9g actual pectin 3x a day and the cadmium went by 10 days, lead nearly halved, in saliva. https://www.romj.org/files/pdf/romj-2013-0306.pdf

yeah ray didnt like pectin because of feeding potentially harmful bacteria , and can also increase gut serotonin through less serotonin transporter (might take high amounts though) (there's already high gut serotonin in IBS, high in crohns too, but in UC its opposite theres low gut serotonin in ulcerative colitis https://academic.oup.com/ibdjournal/article/26/10/1607/5897197 Serotonin transporter is reduced in UC and crohns but with uc comes with lower serotonin https://www.gastrojournal.org/article/S0016-5085(04)00379-8/fulltext#secd69730819e510). in pigs feeding high amounts of pectin led to anti inflammatory state overall , but big changes in bacteria

i might use it for a round every once in a while to get rid of a buildup in toxic metals , rather than continual use (dont want to deplete minerals once metals are taken care of anyway), for the modified form theres some research showing inhibitory effect on mitochondria from a part of it which might be responsible for anti cancer effect due to increased ROS. if that would be relevant for healthy cells or found in high enough amounts idk.

ty for bringing this into awareness looks useful
*(they say this shit is water soluble but it floats on water, u can sort of see a gel forming around the clumps though which is characteristic of the high-methoxyl type

Santosh

@questforhealth said in The relationship between Candida infections and heavy metal toxicity:

@Santosh

Pectin is gentle and natural. These days I like nature and sun and picking my own herbs outside more than buying shit off the internet.]

@Amazoniac

That is genius. Maybe if I ever started farming I could spray this stuff on the crops and people would be getting medication along with their food....

But Emeramide works