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Topical Steroid Solubility and Absorbtion

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  • J
    jamezb46
    last edited by Jun 28, 2024, 10:08 PM

    I'm preparing to create a solution containing Testosterone, DHT, P4, and DHEA for topical administration.

    Based on Haidut's product Cortinon, P4:DHEA ratio should be at least 3:1. For the T:DHT ratio, I want to try 4:3, with a 1:1 ratio of androgens to precursors. So, in total it would be T:DHT:P4:DHEA = 4:3:3:1.

    Based on some of Haidut's research on RP forum, a solution containing 50% DMSO + 50% of "something else" (he listed ethanol, acetone, glycerol as options) should result in near 100% absorption of the steroids when administered topically.

    So, I think 50% DMSO + 50% Ethanol would be a good place to start.

    Now, down to the dosing. Based on the solubility data I was able to find for P4 (54.4 mg/mL = 13.6 mg/0.25mL in Ethanol), I think it's reasonable to expect to be able to dissolve 4mg T, 3 mg DHT, 3mg P4, 1mg DHEA in 0.25 mL of 50% Ethanol 50% DMSO. The 0.25 mL equates to roughly 5 drops from a dropper, with each drop being 0.05mL. I would consider 5 drops = 0.25mL to be a single dose.

    I plan on sourcing from Purple Panda labs, and then homebrewing using insulin syringes to accurately measure the liquid ( 7.5 mL each of DMSO and Ethanol for a 60 day supply of one dose/day) and a milligram scale to measure the raw powders. To get around the drop size problem, I'll purchase a precision pipette to make sure I'm truly getting 0.25mL per dose.

    What do you think of those ratios? Should I change any of them? My goal is to increase muscle mass and strength in the gym. I would consider taking this mixture pre-workout, as it should potentiate its effects rather quickly because of the lack of esters.

    In time there is life but no knowledge; outside time there is knowledge but no life

    M 1 Reply Last reply Jul 18, 2024, 1:50 PM Reply Quote 0
    • M
      metabolicmilk @jamezb46
      last edited by Jul 18, 2024, 1:50 PM

      @jamezb46

      Did you experiment with this?

      1 Reply Last reply Reply Quote 0
      • L
        Lothric
        last edited by Jul 18, 2024, 6:59 PM

        Following out of interest. Log your results

        J 1 Reply Last reply Jul 21, 2024, 4:49 PM Reply Quote 0
        • J
          jamezb46 @Lothric
          last edited by Jul 21, 2024, 4:49 PM

          @Lothric I decided on dissolving T in vitamin E. Similar to progest-e except I will use T instead of P4.

          In time there is life but no knowledge; outside time there is knowledge but no life

          M 1 Reply Last reply Jul 22, 2024, 7:38 PM Reply Quote 0
          • M
            metabolicmilk @jamezb46
            last edited by Jul 22, 2024, 7:38 PM

            @jamezb46
            How has the experience in vitamin e been? What dosage are you using and what solubility did you achieve?

            J 1 Reply Last reply Jul 23, 2024, 5:08 AM Reply Quote 0
            • J
              jamezb46 @metabolicmilk
              last edited by jamezb46 Jul 23, 2024, 5:12 AM Jul 23, 2024, 5:08 AM

              @metabolicmilk

              Still waiting on my shipment from PPL. Will update this thread after I dissolve the powder and again after a few weeks of using it.

              In time there is life but no knowledge; outside time there is knowledge but no life

              1 Reply Last reply Reply Quote 0
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