Topical Steroid Solubility and Absorbtion
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I'm preparing to create a solution containing Testosterone, DHT, P4, and DHEA for topical administration.
Based on Haidut's product Cortinon, P4:DHEA ratio should be at least 3:1. For the T:DHT ratio, I want to try 4:3, with a 1:1 ratio of androgens to precursors. So, in total it would be T:DHT:P4:DHEA = 4:3:3:1.
Based on some of Haidut's research on RP forum, a solution containing 50% DMSO + 50% of "something else" (he listed ethanol, acetone, glycerol as options) should result in near 100% absorption of the steroids when administered topically.
So, I think 50% DMSO + 50% Ethanol would be a good place to start.
Now, down to the dosing. Based on the solubility data I was able to find for P4 (54.4 mg/mL = 13.6 mg/0.25mL in Ethanol), I think it's reasonable to expect to be able to dissolve 4mg T, 3 mg DHT, 3mg P4, 1mg DHEA in 0.25 mL of 50% Ethanol 50% DMSO. The 0.25 mL equates to roughly 5 drops from a dropper, with each drop being 0.05mL. I would consider 5 drops = 0.25mL to be a single dose.
I plan on sourcing from Purple Panda labs, and then homebrewing using insulin syringes to accurately measure the liquid ( 7.5 mL each of DMSO and Ethanol for a 60 day supply of one dose/day) and a milligram scale to measure the raw powders. To get around the drop size problem, I'll purchase a precision pipette to make sure I'm truly getting 0.25mL per dose.
What do you think of those ratios? Should I change any of them? My goal is to increase muscle mass and strength in the gym. I would consider taking this mixture pre-workout, as it should potentiate its effects rather quickly because of the lack of esters.
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Did you experiment with this?
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Following out of interest. Log your results
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@Lothric I decided on dissolving T in vitamin E. Similar to progest-e except I will use T instead of P4.
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@jamezb46
How has the experience in vitamin e been? What dosage are you using and what solubility did you achieve? -
Still waiting on my shipment from PPL. Will update this thread after I dissolve the powder and again after a few weeks of using it.
