Glucose loading cures everything?
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@gentlepotato It took me a few weeks sending multiple messages. He apologized for that. I think because of the discussion here and on the RPF he has suddenly gotten a new influx of patients. If you would like to pm me your phone number I can text it to him.
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@S-Holmes thank you for the offer! I'm in Europe, so different time zone completely, therefore email would be preferred. If you have his email, would you be able to send it to me?
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@gentlepotato Sure. Will PM.
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My gut feeling tells me to explore fat with the glucose, and I've tried to search the forum about this without finding anything (I find the search function doesn't work well - am I the only one?): What fat source has the most nutrients per grams that would be supportive, in terms of neurotransmitters, brain health, Krebs cycle, mitochondria?
The gut feeling is likely informed by the video by Rob Phair that I posted the other day, where he talks about the GABA shunt.
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Without assessing the validity of your gut feeling (maybe you don't need exogenous fatty acids but more endogeneous synthesis with the help of B5 and B6 and B7?),
@gentlepotato said in Glucose loading cures everything?:What fat source has the most nutrients per grams that would be supportive, in terms of neurotransmitters, brain health, Krebs cycle, mitochondria?
I'd confidently say cocoa butter (pellets) and beef or lamb tallow to this, as they contain lots of valuable long-chain saturated FAs and stearic acid (for mitogenesis) especially.
Or instead of tallow: Fatty cuts of beef or lamb and eat/keep/separate the fats after c. 3hrs of low-temp cooking.I haven't yet read through that paper you posted and the itaconate ways.
Thanks @S-Holmes. Not sure which homeopathic remedy would be right for me right now. But I've added Glechoma tincture for my detox suppport (Lysimachia=Gold Coin Grass=Jin Qian Cao may be more available to some). -
@CrumblingCookie said in Glucose loading cures everything?:
Without assessing the validity of your gut feeling (maybe you don't need exogenous fatty acids but more endogeneous synthesis with the help of B5 and B6 and B7?),
Thanks, I'll look into that!
I'd confidently say cocoa butter (pellets) and beef or lamb tallow to this, as they contain lots of valuable long-chain saturated FAs and stearic acid (for mitogenesis) especially.
Or instead of tallow: Fatty cuts of beef or lamb and eat/keep/separate the fats after c. 3hrs of low-temp cooking.Thank you! I think my gut feeling often knows, but I need to do so much unlearning about food to be able to listen well to it. It's getting better, but one way to unlearn is to research and ask others. And hearing that answer make it easier to tap into the gut feeling I was having.
Which has been asking for cocoa, but I thought it meant powder, because that's all I have at the moment. It also asked for more tallow, but I keep forgetting to use it because it's in the fridge and not on the countertop. Gonna have to keep some next to the stovetop. I always keep the tallow when I make oxtails, so I've got lots, and use it as a face cream too. Tallow is amazing.
I will experiment a little and report back.
How are you getting on though, @CrumblingCookie?
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This just happened. Dr Stephens had asked me about sleep and dreams. I've only ever had disturbing dreams or nightmares that wake me up shaking with fear. He told me that my nightmares will end. He treats about 40 combat veterans with ptsd (and nightmares). All are free of their ptsd symptoms. And last night I had the most amazing and comforting dream. The first I remember, ever.
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@S-Holmes Beautiful report! Keep em coming.
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@S-Holmes said in Glucose loading cures everything?:
This just happened. Dr Stephens had asked me about sleep and dreams. I've only ever had disturbing dreams or nightmares that wake me up shaking with fear. He told me that my nightmares will end. He treats about 40 combat veterans with ptsd (and nightmares). All are free of their ptsd symptoms. And last night I had the most amazing and comforting dream. The first I remember, ever.
Wow! Thank you for sharing. Incredible.
Thank you everyone for sharing your insights and experiences.
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Random report here:
I have been doing the protocol for approximately 4-5 weeks. Nothing major to report positive or negative, but it's been subtly neutral-to-positive enough that I've kept on it. I am taking approximately 5 tbsp 3x per day (so in the ballpark of 600 calories of dextrose per day).
That said, I am concerned about the potential of becoming dependent on big doses of dextrose and I have some upcoming events which will leave me without dextrose for a week or two. So yesterday I decided to test out not having any. It went fine. I didn't crave it and I didn't notice any type of withdrawal symptoms going from 600 calories per day to 0 in one shot. I was glad about that.
I'm curious whether anyone else has concerns about developing a dependency and/or has any related experience to share.
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@jjk_learning Our brain has an innate dependence on glucose, but you already know that. I have my mom taking Smarties for her doses. Could you do that instead? Or maybe just take half doses?
Since we're alll experimenting, if you need to go cold turkey I hope you'll keep us posted.
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@S-Holmes I will keep you posted! Keep us posted on your dream world as well
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@S-Holmes
I'm trying the smarties as well. But they make me nauseous quickly. I don't have that with the sugar water. -
I have a little nausea with all doses after noon, regardless of whether taking Smarties or dextrose. Spicy food seems to help. I'm trusting that will get better over time.
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S S.Holmes referenced this topic on
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I've continued doing 1 tbsp at a time, and it's working great. The few times I've taken more glucose I've felt worse. I've had symptoms of low blood sugar, interrupted sleep and low pulse. So I'm sticking to 1 tbsp 12-14 times a day!
I already consistently do much more than four weeks ago, small things around the house, sit up and stand more (my symptoms have been so severe I've been "bed/couch bound" for most of the last year), and have much more time for things I enjoy. It's been lovely!
But I need a lot of rest. Which is not surprising, since I've been housebound for more than four years. My body has become very deconditioned, especially over the last year, which has been my worst year physically.
I sense my body system and brain needs a lot of healing on the inside, so I rest, and let that be the priority. I think my hormonal system is healing, as I see several signs of that! I trust in the process, and that with time I will have the capacity to do even more.
And the rest is magnificent.
It's wild to actually rest, after not having felt like I am recouparating much for 18 years, and hardly at all for the last eight. Really understanding the Itaconate shunt and the repercussions of it make me understand, on a new level, why rest has never made a big difference. (I learnt about it a few years ago, but I didn't really understand it the way I have over the last weeks.)
Now the pain is practically gone, the PEM (activity induced symptom increased, cardinal symptom of ME) is gone, and I wake up refreshed every morning. My circadian rhythm is so much better. I wake up early every morning, and feel tired in the evening.
Only issue is that I live far north, so at the moment it never really gets dark here. Even with my orange glasses it feels like daytime at 10pm, so my mind is a bit confused about that. However, yesterday I made an effort to get to bed at 11 and had a longer night's sleep. I'm delighted!
I use a timer and set it for 60 minutes. In the beginning I could feel the need for more glucose as it got closer to the alarm. I would check the timer and somewhere between 45-59 minutes had passed. Now I've missed it a few times, which makes me think I'm storing more glucose!
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@gentlepotato Amazing report! I can relate to the fatigue...my life story, esp. since Feb of 2020 and post covid syndrome.
I can tell progress is being made, but it's good that I understand retracing! I had (painful) frozen shoulder 15 years ago. It went away with ultrasound treatments, but tinnitus on that side became worse and has been ever since. So I trust that once the shoulder heals properly (this time) the tinnitus should also improve.
We just held a family reunion at our farm yesterday...4 generations of family in attendance. I had no help preparing for it (my husband DID hire a man to mow the property). I told him I would be surprised if I didn't need to cancel, but I didn't!
Keep those encouraging reports coming! Not so encouraging reports are welcome too, since Dr Stephens said there will be bumps along the way to healing and others can benefit from our trials.
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@S-Holmes Thank you for sharing as well, and how wonderful you were able to have the family reunion. Hope it was a lovely get together!
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@S-Holmes
wait ... your tinnitus and shoulder are related?... ever since my right shoulder and shoulder blade have been injured i have tinnitus along with jaw issues.
glucose realy is great for energy, i have the appetite of my 20year old self again and my manhood has improved immensely.
the "biggest" sideeffect thus far is being irritated/angry. i would assume due to either blood sugar dropping or my metabolism ramping up alot. eating something resolves it rather quickly tho.
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@gentlepotato Epic post regarding the Itaconate Shunt + GentlePotato Hypothesis as to why glucose-only has specific action stopping the Itaconate Shunt and thus improving (in Peat's words from the radio transcription you provided) both the "capacity" and "efficiency" of glucose oxidation.
The links to GABA and type-1-diabetes/autoimmune antibodies in the quote from the Peat interview were noteworthy, too.
Some random observations (expressing enthusiasm for GentlePotato's hypothesized mechanisms): In my own case, I respond to anti-excitatory supplements that are specifically GABA agonists (androsterone, kava) or operating directly on GABA receptors (progesterone). My subjective experience of plain sugar (sucrose) is similar. The mechanism(s) you mention and the overlap of our symptoms (those of us experimenting with and, at least at times, responding well to high-dose sugar or glucose as a supplement) makes me want to try glucose-only to compare. I think I do best with sucrose when I'm already uninflamed, good energetic capacity, i.e. oxidizing glucose well (which also would be contingent on having the enzymes or un-shunted baseline to be able to break sucrose down into glucose). According to your theory, glucose-only would be especially helpful when the sucrose-to-glucose pathway isn't working well and/or some stressor (e.g., TBI) has caused an Itaconate Shunt process to begin.
Upthread mentions of derangements in circadian rhythm are also interesting. Peating for several years and feeling like I'd made bioenergetic quantum leaps toward health (interpreted as "deeper capacity for" and "more efficient" glucose oxidation, specifically in brain tissue [although without a "CGM-like device" to measure such things directly, this is obviously a speculative interpretation])...only then did I want to wake up in the morning. After lifelong night-owl/sleep-deprivation/irregular-sleep patterns, I started to want to sleep "normal hours" and work/concentrate in the morning in the last six years or so. Type-1 diabetic here, btw.
Please speculate more when you've got more thoughts on the mechanisms in play explaining why sucrose-only might make a difference.
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@Ben I believe so, at least in my case. I'm testing that theory now.
